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Epidemic of venereal treponematosis in wild monkeys: a paradigm for syphilis origin.
New Microbes New Infect. 2020 May; 35:100670.NM

Abstract

Treponema pallidum infections have been primarily known as slightly contagious mucocutaneous infections called yaws (tropical Africa and America) and bejel (subtropical North Africa). T. pallidum emerged as a highly infectious venereal syphilis agent in South America, probably about 500 years ago, and because of its venereal transmission, it quickly caused a worldwide pandemic. The disease manifests as lesions, including a chancre; then antibodies become detectable when or slightly after the chancre appears, and before the development of a rash and other systemic manifestations. Venereal diseases are poorly known in monkeys. During fieldwork in Senegal, we discovered an epizootic outbreak of venereal disease that we explored. We detected a venereal form of T. pallidum subsp. pertenue infection in green monkeys (Chlorocebus sabaeus), then observed an epizootic outbreak in Senegal and its spread among baboons a year later. Comparative analysis of T. pallidum genomes from the monkeys' chancres and other Treponema genomes showed an acceleration of the number of single nucleotide polymorphisms, comparable to that observed in syphilis. Identified T. pallidum clones seem to be epizootic through the acceleration of their mutation rate, which is linked to their larger diffusion.

Authors+Show Affiliations

Aix Marseille Univ, IRD, AP-HM, MEФI, Marseille, France. IHU-Méditerranée Infection, Marseille, France.IHU-Méditerranée Infection, Marseille, France. Aix Marseille Univ, IRD, AP-HM, SSA, VITROME, Marseille, France.Aix Marseille Univ, IRD, AP-HM, MEФI, Marseille, France. IHU-Méditerranée Infection, Marseille, France.Aix Marseille Univ, IRD, AP-HM, MEФI, Marseille, France. IHU-Méditerranée Infection, Marseille, France.Aix Marseille Univ, IRD, AP-HM, MEФI, Marseille, France. IHU-Méditerranée Infection, Marseille, France.Aix Marseille Univ, IRD, AP-HM, MEФI, Marseille, France. IHU-Méditerranée Infection, Marseille, France.VITROME, Campus International UCAD-IRD, Dakar, Senegal.IHU-Méditerranée Infection, Marseille, France. Aix Marseille Univ, IRD, AP-HM, SSA, VITROME, Marseille, France.Aix Marseille Univ, IRD, AP-HM, MEФI, Marseille, France. IHU-Méditerranée Infection, Marseille, France.Aix Marseille Univ, IRD, AP-HM, MEФI, Marseille, France. IHU-Méditerranée Infection, Marseille, France.Aix Marseille Univ, IRD, AP-HM, MEФI, Marseille, France. IHU-Méditerranée Infection, Marseille, France.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32368345

Citation

Mediannikov, O, et al. "Epidemic of Venereal Treponematosis in Wild Monkeys: a Paradigm for Syphilis Origin." New Microbes and New Infections, vol. 35, 2020, p. 100670.
Mediannikov O, Fenollar F, Davoust B, et al. Epidemic of venereal treponematosis in wild monkeys: a paradigm for syphilis origin. New Microbes New Infect. 2020;35:100670.
Mediannikov, O., Fenollar, F., Davoust, B., Amanzougaghene, N., Lepidi, H., Arzouni, J. P., Diatta, G., Sokhna, C., Delerce, J., Levasseur, A., & Raoult, D. (2020). Epidemic of venereal treponematosis in wild monkeys: a paradigm for syphilis origin. New Microbes and New Infections, 35, 100670. https://doi.org/10.1016/j.nmni.2020.100670
Mediannikov O, et al. Epidemic of Venereal Treponematosis in Wild Monkeys: a Paradigm for Syphilis Origin. New Microbes New Infect. 2020;35:100670. PubMed PMID: 32368345.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Epidemic of venereal treponematosis in wild monkeys: a paradigm for syphilis origin. AU - Mediannikov,O, AU - Fenollar,F, AU - Davoust,B, AU - Amanzougaghene,N, AU - Lepidi,H, AU - Arzouni,J-P, AU - Diatta,G, AU - Sokhna,C, AU - Delerce,J, AU - Levasseur,A, AU - Raoult,D, Y1 - 2020/03/26/ PY - 2019/12/05/received PY - 2020/03/19/revised PY - 2020/03/19/accepted PY - 2020/5/6/entrez PY - 2020/5/6/pubmed PY - 2020/5/6/medline KW - Baboon KW - Green monkey KW - Senegal KW - Syphilis KW - Treponema KW - West Africa SP - 100670 EP - 100670 JF - New microbes and new infections JO - New Microbes New Infect VL - 35 N2 - Treponema pallidum infections have been primarily known as slightly contagious mucocutaneous infections called yaws (tropical Africa and America) and bejel (subtropical North Africa). T. pallidum emerged as a highly infectious venereal syphilis agent in South America, probably about 500 years ago, and because of its venereal transmission, it quickly caused a worldwide pandemic. The disease manifests as lesions, including a chancre; then antibodies become detectable when or slightly after the chancre appears, and before the development of a rash and other systemic manifestations. Venereal diseases are poorly known in monkeys. During fieldwork in Senegal, we discovered an epizootic outbreak of venereal disease that we explored. We detected a venereal form of T. pallidum subsp. pertenue infection in green monkeys (Chlorocebus sabaeus), then observed an epizootic outbreak in Senegal and its spread among baboons a year later. Comparative analysis of T. pallidum genomes from the monkeys' chancres and other Treponema genomes showed an acceleration of the number of single nucleotide polymorphisms, comparable to that observed in syphilis. Identified T. pallidum clones seem to be epizootic through the acceleration of their mutation rate, which is linked to their larger diffusion. SN - 2052-2975 UR - https://www.unboundmedicine.com/medline/citation/32368345/Epidemic_of_venereal_treponematosis_in_wild_monkeys:_a_paradigm_for_syphilis_origin L2 - https://linkinghub.elsevier.com/retrieve/pii/S2052-2975(20)30022-6 DB - PRIME DP - Unbound Medicine ER -
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