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Potential therapeutic targets and promising drugs for combating SARS-CoV-2.
Br J Pharmacol. 2020 07; 177(14):3147-3161.BJ

Abstract

As of April 9, 2020, a novel coronavirus (SARS-CoV-2) had caused 89,931 deaths and 1,503,900 confirmed cases worldwide, which indicates an increasingly severe and uncontrollable situation. Initially, little was known about the virus. As research continues, we now know the genome structure, epidemiological and clinical characteristics, and pathogenic mechanisms of SARS-CoV-2. Based on this knowledge, potential targets involved in the processes of virus pathogenesis need to be identified, and the discovery or development of drugs based on these potential targets is the most pressing need. Here, we have summarized the potential therapeutic targets involved in virus pathogenesis and discuss the advances, possibilities, and significance of drugs based on these targets for treating SARS-CoV-2. This review will facilitate the identification of potential targets and provide clues for drug development that can be translated into clinical applications for combating SARS-CoV-2.

Authors+Show Affiliations

Department of Pharmacy, Anhui Provincial Cancer Hospital, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.Department of Pharmacy, Anhui Provincial Hospital, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, China.Department of Pharmacy, Anhui Provincial Hospital, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China. Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, China.Department of Pharmacy, Anhui Provincial Hospital, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

32368792

Citation

Zhou, Hong, et al. "Potential Therapeutic Targets and Promising Drugs for Combating SARS-CoV-2." British Journal of Pharmacology, vol. 177, no. 14, 2020, pp. 3147-3161.
Zhou H, Fang Y, Xu T, et al. Potential therapeutic targets and promising drugs for combating SARS-CoV-2. Br J Pharmacol. 2020;177(14):3147-3161.
Zhou, H., Fang, Y., Xu, T., Ni, W. J., Shen, A. Z., & Meng, X. M. (2020). Potential therapeutic targets and promising drugs for combating SARS-CoV-2. British Journal of Pharmacology, 177(14), 3147-3161. https://doi.org/10.1111/bph.15092
Zhou H, et al. Potential Therapeutic Targets and Promising Drugs for Combating SARS-CoV-2. Br J Pharmacol. 2020;177(14):3147-3161. PubMed PMID: 32368792.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Potential therapeutic targets and promising drugs for combating SARS-CoV-2. AU - Zhou,Hong, AU - Fang,Yan, AU - Xu,Tao, AU - Ni,Wei-Jian, AU - Shen,Ai-Zong, AU - Meng,Xiao-Ming, Y1 - 2020/06/05/ PY - 2020/04/09/received PY - 2020/04/17/revised PY - 2020/04/22/accepted PY - 2020/5/6/pubmed PY - 2020/7/3/medline PY - 2020/5/6/entrez SP - 3147 EP - 3161 JF - British journal of pharmacology JO - Br J Pharmacol VL - 177 IS - 14 N2 - As of April 9, 2020, a novel coronavirus (SARS-CoV-2) had caused 89,931 deaths and 1,503,900 confirmed cases worldwide, which indicates an increasingly severe and uncontrollable situation. Initially, little was known about the virus. As research continues, we now know the genome structure, epidemiological and clinical characteristics, and pathogenic mechanisms of SARS-CoV-2. Based on this knowledge, potential targets involved in the processes of virus pathogenesis need to be identified, and the discovery or development of drugs based on these potential targets is the most pressing need. Here, we have summarized the potential therapeutic targets involved in virus pathogenesis and discuss the advances, possibilities, and significance of drugs based on these targets for treating SARS-CoV-2. This review will facilitate the identification of potential targets and provide clues for drug development that can be translated into clinical applications for combating SARS-CoV-2. SN - 1476-5381 UR - https://www.unboundmedicine.com/medline/citation/32368792/Potential_therapeutic_targets_and_promising_drugs_for_combating_SARS_CoV_2_ L2 - https://doi.org/10.1111/bph.15092 DB - PRIME DP - Unbound Medicine ER -