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The Prevalence of Olfactory and Gustatory Dysfunction in COVID-19 Patients: A Systematic Review and Meta-analysis.
Otolaryngol Head Neck Surg. 2020 07; 163(1):3-11.OH

Abstract

OBJECTIVE

To determine the pooled global prevalence of olfactory and gustatory dysfunction in patients with the 2019 novel coronavirus (COVID-19).

DATA SOURCES

Literature searches of PubMed, Embase, and Scopus were conducted on April 19, 2020, to include articles written in English that reported the prevalence of olfactory or gustatory dysfunction in COVID-19 patients.

REVIEW METHODS

Search strategies developed for each database contained keywords such as anosmia, dysgeusia, and COVID-19. Resulting articles were imported into a systematic review software and underwent screening. Data from articles that met inclusion criteria were extracted and analyzed. Meta-analysis using pooled prevalence estimates in a random-effects model were calculated.

RESULTS

Ten studies were analyzed for olfactory dysfunction (n = 1627), demonstrating 52.73% (95% CI, 29.64%-75.23%) prevalence among patients with COVID-19. Nine studies were analyzed for gustatory dysfunction (n = 1390), demonstrating 43.93% (95% CI, 20.46%-68.95%) prevalence. Subgroup analyses were conducted for studies evaluating olfactory dysfunction using nonvalidated and validated instruments and demonstrated 36.64% (95% CI, 18.31%-57.24%) and 86.60% (95% CI, 72.95%-95.95%) prevalence, respectively.

CONCLUSIONS

Olfactory and gustatory dysfunction are common symptoms in patients with COVID-19 and may represent early symptoms in the clinical course of infection. Increased awareness of this fact may encourage earlier diagnosis and treatment, as well as heighten vigilance for viral transmission. To our knowledge, this is the first meta-analysis to report on the prevalence of these symptoms in COVID-19 patients.

Authors+Show Affiliations

Drexel University College of Medicine, Philadelphia, Pennsylvania, USA.Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York, USA.Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York, USA.Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York, USA. Department of Otolaryngology-Head and Neck Surgery, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Northwell Health System, Hempstead, New York, USA.Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York, USA. Department of Otolaryngology-Head and Neck Surgery, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Northwell Health System, Hempstead, New York, USA.

Pub Type(s)

Journal Article
Meta-Analysis
Systematic Review

Language

eng

PubMed ID

32369429

Citation

Tong, Jane Y., et al. "The Prevalence of Olfactory and Gustatory Dysfunction in COVID-19 Patients: a Systematic Review and Meta-analysis." Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery, vol. 163, no. 1, 2020, pp. 3-11.
Tong JY, Wong A, Zhu D, et al. The Prevalence of Olfactory and Gustatory Dysfunction in COVID-19 Patients: A Systematic Review and Meta-analysis. Otolaryngol Head Neck Surg. 2020;163(1):3-11.
Tong, J. Y., Wong, A., Zhu, D., Fastenberg, J. H., & Tham, T. (2020). The Prevalence of Olfactory and Gustatory Dysfunction in COVID-19 Patients: A Systematic Review and Meta-analysis. Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery, 163(1), 3-11. https://doi.org/10.1177/0194599820926473
Tong JY, et al. The Prevalence of Olfactory and Gustatory Dysfunction in COVID-19 Patients: a Systematic Review and Meta-analysis. Otolaryngol Head Neck Surg. 2020;163(1):3-11. PubMed PMID: 32369429.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Prevalence of Olfactory and Gustatory Dysfunction in COVID-19 Patients: A Systematic Review and Meta-analysis. AU - Tong,Jane Y, AU - Wong,Amanda, AU - Zhu,Daniel, AU - Fastenberg,Judd H, AU - Tham,Tristan, Y1 - 2020/05/05/ PY - 2020/5/6/pubmed PY - 2020/7/16/medline PY - 2020/5/6/entrez KW - COVID-19 KW - SARS-CoV-2 KW - ageusia KW - anosmia KW - coronavirus KW - gustatory KW - olfactory SP - 3 EP - 11 JF - Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery JO - Otolaryngol Head Neck Surg VL - 163 IS - 1 N2 - OBJECTIVE: To determine the pooled global prevalence of olfactory and gustatory dysfunction in patients with the 2019 novel coronavirus (COVID-19). DATA SOURCES: Literature searches of PubMed, Embase, and Scopus were conducted on April 19, 2020, to include articles written in English that reported the prevalence of olfactory or gustatory dysfunction in COVID-19 patients. REVIEW METHODS: Search strategies developed for each database contained keywords such as anosmia, dysgeusia, and COVID-19. Resulting articles were imported into a systematic review software and underwent screening. Data from articles that met inclusion criteria were extracted and analyzed. Meta-analysis using pooled prevalence estimates in a random-effects model were calculated. RESULTS: Ten studies were analyzed for olfactory dysfunction (n = 1627), demonstrating 52.73% (95% CI, 29.64%-75.23%) prevalence among patients with COVID-19. Nine studies were analyzed for gustatory dysfunction (n = 1390), demonstrating 43.93% (95% CI, 20.46%-68.95%) prevalence. Subgroup analyses were conducted for studies evaluating olfactory dysfunction using nonvalidated and validated instruments and demonstrated 36.64% (95% CI, 18.31%-57.24%) and 86.60% (95% CI, 72.95%-95.95%) prevalence, respectively. CONCLUSIONS: Olfactory and gustatory dysfunction are common symptoms in patients with COVID-19 and may represent early symptoms in the clinical course of infection. Increased awareness of this fact may encourage earlier diagnosis and treatment, as well as heighten vigilance for viral transmission. To our knowledge, this is the first meta-analysis to report on the prevalence of these symptoms in COVID-19 patients. SN - 1097-6817 UR - https://www.unboundmedicine.com/medline/citation/32369429/The_Prevalence_of_Olfactory_and_Gustatory_Dysfunction_in_COVID_19_Patients:_A_Systematic_Review_and_Meta_analysis_ L2 - https://journals.sagepub.com/doi/10.1177/0194599820926473?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -