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Coronavirus disease 2019 among pregnant Chinese women: case series data on the safety of vaginal birth and breastfeeding.
BJOG. 2020 08; 127(9):1109-1115.BJOG

Abstract

OBJECTIVE

To assess whether vaginal secretions and breast milk of women with coronavirus disease 2019 (COVID-19) contain severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

DESIGN

Single centre cohort study.

SETTING

Renmin Hospital of Wuhan University, Wuhan, Hubei province, China.

POPULATION

We studied 13 SARS-CoV-2-infected pregnant women diagnosed between 31 January and 9 March 2020.

METHODS

We collected clinical data, vaginal secretions, stool specimens and breast milk from SARS-CoV-2-infected women during different stages of pregnancy and collected neonatal throat and anal swabs.

MAIN OUTCOMES AND MEASURES

We assessed viral presence in different biosamples.

RESULTS

Of the 13 women with COVID-19, five were in their first trimester, three in their second trimester and five in their third trimester. Of the five women in their third trimester who gave birth, all delivered live newborns. Among these five deliveries, the primary adverse perinatal outcomes included premature delivery (n = 2) and neonatal pneumonia (n = 2). One of nine stool samples was positive; all 13 vaginal secretion samples, and five throat swabs and four anal swabs collected from neonates, were negative for the novel coronavirus. However, one of three samples of breast milk was positive by viral nucleic acid testing.

CONCLUSIONS

In this case series of 13 pregnant women with COVID-19, we observed negative viral test results in vaginal secretion specimens, suggesting that a vaginal delivery may be a safe delivery option. However, additional research is urgently needed to examine breast milk and the potential risk for viral contamination.

TWEETABLE ABSTRACT

New evidence for the safety of vaginal delivery and breastfeeding in pregnant women infected with SARS-CoV-2, positive viral result in a breast-milk sample.

Authors+Show Affiliations

The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.Department of Radiology, First Affiliated Hospital to Army Medical University, Chongqing, China.Renmin Hospital of Wuhan University, Wuchang, Wuhan, China.The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China.Renmin Hospital of Wuhan University, Wuchang, Wuhan, China. Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China.The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.Department of Obstetrics and Gynaecology, Monash University, Clayton, Victoria, Australia.Bloomberg Faculty of Nursing, University of Toronto, Toronto, Ontario, Canada.Renmin Hospital of Wuhan University, Wuchang, Wuhan, China.Renmin Hospital of Wuhan University, Wuchang, Wuhan, China.The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

32369656

Citation

Wu, Y, et al. "Coronavirus Disease 2019 Among Pregnant Chinese Women: Case Series Data On the Safety of Vaginal Birth and Breastfeeding." BJOG : an International Journal of Obstetrics and Gynaecology, vol. 127, no. 9, 2020, pp. 1109-1115.
Wu Y, Liu C, Dong L, et al. Coronavirus disease 2019 among pregnant Chinese women: case series data on the safety of vaginal birth and breastfeeding. BJOG. 2020;127(9):1109-1115.
Wu, Y., Liu, C., Dong, L., Zhang, C., Chen, Y., Liu, J., Zhang, C., Duan, C., Zhang, H., Mol, B. W., Dennis, C. L., Yin, T., Yang, J., & Huang, H. (2020). Coronavirus disease 2019 among pregnant Chinese women: case series data on the safety of vaginal birth and breastfeeding. BJOG : an International Journal of Obstetrics and Gynaecology, 127(9), 1109-1115. https://doi.org/10.1111/1471-0528.16276
Wu Y, et al. Coronavirus Disease 2019 Among Pregnant Chinese Women: Case Series Data On the Safety of Vaginal Birth and Breastfeeding. BJOG. 2020;127(9):1109-1115. PubMed PMID: 32369656.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Coronavirus disease 2019 among pregnant Chinese women: case series data on the safety of vaginal birth and breastfeeding. AU - Wu,Y, AU - Liu,C, AU - Dong,L, AU - Zhang,C, AU - Chen,Y, AU - Liu,J, AU - Zhang,C, AU - Duan,C, AU - Zhang,H, AU - Mol,B W, AU - Dennis,C-L, AU - Yin,T, AU - Yang,J, AU - Huang,H, Y1 - 2020/05/26/ PY - 2020/04/20/accepted PY - 2020/5/6/pubmed PY - 2020/10/22/medline PY - 2020/5/6/entrez KW - Breast milk KW - coronavirus disease 2019 KW - vaginal secretions SP - 1109 EP - 1115 JF - BJOG : an international journal of obstetrics and gynaecology JO - BJOG VL - 127 IS - 9 N2 - OBJECTIVE: To assess whether vaginal secretions and breast milk of women with coronavirus disease 2019 (COVID-19) contain severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). DESIGN: Single centre cohort study. SETTING: Renmin Hospital of Wuhan University, Wuhan, Hubei province, China. POPULATION: We studied 13 SARS-CoV-2-infected pregnant women diagnosed between 31 January and 9 March 2020. METHODS: We collected clinical data, vaginal secretions, stool specimens and breast milk from SARS-CoV-2-infected women during different stages of pregnancy and collected neonatal throat and anal swabs. MAIN OUTCOMES AND MEASURES: We assessed viral presence in different biosamples. RESULTS: Of the 13 women with COVID-19, five were in their first trimester, three in their second trimester and five in their third trimester. Of the five women in their third trimester who gave birth, all delivered live newborns. Among these five deliveries, the primary adverse perinatal outcomes included premature delivery (n = 2) and neonatal pneumonia (n = 2). One of nine stool samples was positive; all 13 vaginal secretion samples, and five throat swabs and four anal swabs collected from neonates, were negative for the novel coronavirus. However, one of three samples of breast milk was positive by viral nucleic acid testing. CONCLUSIONS: In this case series of 13 pregnant women with COVID-19, we observed negative viral test results in vaginal secretion specimens, suggesting that a vaginal delivery may be a safe delivery option. However, additional research is urgently needed to examine breast milk and the potential risk for viral contamination. TWEETABLE ABSTRACT: New evidence for the safety of vaginal delivery and breastfeeding in pregnant women infected with SARS-CoV-2, positive viral result in a breast-milk sample. SN - 1471-0528 UR - https://www.unboundmedicine.com/medline/citation/32369656/Coronavirus_disease_2019_among_pregnant_Chinese_women:_case_series_data_on_the_safety_of_vaginal_birth_and_breastfeeding_ L2 - https://doi.org/10.1111/1471-0528.16276 DB - PRIME DP - Unbound Medicine ER -