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A diet containing n-3 and n-6 fatty acids favorably alters the renal phospholipids, eicosanoid synthesis and plasma lipids in nephrotic rats.
Lipids. 1988 Nov; 23(11):1059-63.L

Abstract

The nephrotic syndrome was induced in rats by intravenous adriamycin (3 mg/kg). The rats were then divided into four groups which, for six weeks, were pair-fed diets containing beef tallow (BT), fish oil (FO), a source of n-3 fatty acids, evening primrose oil (EPO), a source of n-6 fatty acids, or a combination of evening primrose oil and fish oil, 75:25 (EPO:FO). The fat content of the diets was 15%. Significant incorporation of the fatty acids into kidney phospholipids was demonstrated. Diets containing FO, EPO and EPO:FO lowered plasma triglycerides and total cholesterol levels as compared with diets containing BT. Only EPO:FO raised high density lipoprotein (HDL) cholesterol levels, as compared with BT. The combination EPO:FO prevented the tenfold suppression of aortic 6-keto-PGF1 alpha caused by FO. These changes in plasma lipids and eicosanoid production are potentially antiatherogenic and may prevent glomerular sclerosis. The combination of EPO and FO, containing n-6 and n-3 fatty acids may offer advantages over either family of fatty acids in this model of nephrotic syndrome.

Authors+Show Affiliations

Department of Internal Medicine, University of Cincinnati Medical Center, OH 45267-0585.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3237005

Citation

Barcelli, U O., et al. "A Diet Containing N-3 and N-6 Fatty Acids Favorably Alters the Renal Phospholipids, Eicosanoid Synthesis and Plasma Lipids in Nephrotic Rats." Lipids, vol. 23, no. 11, 1988, pp. 1059-63.
Barcelli UO, Beach DC, Thompson B, et al. A diet containing n-3 and n-6 fatty acids favorably alters the renal phospholipids, eicosanoid synthesis and plasma lipids in nephrotic rats. Lipids. 1988;23(11):1059-63.
Barcelli, U. O., Beach, D. C., Thompson, B., Weiss, M., & Pollak, V. E. (1988). A diet containing n-3 and n-6 fatty acids favorably alters the renal phospholipids, eicosanoid synthesis and plasma lipids in nephrotic rats. Lipids, 23(11), 1059-63.
Barcelli UO, et al. A Diet Containing N-3 and N-6 Fatty Acids Favorably Alters the Renal Phospholipids, Eicosanoid Synthesis and Plasma Lipids in Nephrotic Rats. Lipids. 1988;23(11):1059-63. PubMed PMID: 3237005.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A diet containing n-3 and n-6 fatty acids favorably alters the renal phospholipids, eicosanoid synthesis and plasma lipids in nephrotic rats. AU - Barcelli,U O, AU - Beach,D C, AU - Thompson,B, AU - Weiss,M, AU - Pollak,V E, PY - 1988/11/1/pubmed PY - 1988/11/1/medline PY - 1988/11/1/entrez SP - 1059 EP - 63 JF - Lipids JO - Lipids VL - 23 IS - 11 N2 - The nephrotic syndrome was induced in rats by intravenous adriamycin (3 mg/kg). The rats were then divided into four groups which, for six weeks, were pair-fed diets containing beef tallow (BT), fish oil (FO), a source of n-3 fatty acids, evening primrose oil (EPO), a source of n-6 fatty acids, or a combination of evening primrose oil and fish oil, 75:25 (EPO:FO). The fat content of the diets was 15%. Significant incorporation of the fatty acids into kidney phospholipids was demonstrated. Diets containing FO, EPO and EPO:FO lowered plasma triglycerides and total cholesterol levels as compared with diets containing BT. Only EPO:FO raised high density lipoprotein (HDL) cholesterol levels, as compared with BT. The combination EPO:FO prevented the tenfold suppression of aortic 6-keto-PGF1 alpha caused by FO. These changes in plasma lipids and eicosanoid production are potentially antiatherogenic and may prevent glomerular sclerosis. The combination of EPO and FO, containing n-6 and n-3 fatty acids may offer advantages over either family of fatty acids in this model of nephrotic syndrome. SN - 0024-4201 UR - https://www.unboundmedicine.com/medline/citation/3237005/A_diet_containing_n_3_and_n_6_fatty_acids_favorably_alters_the_renal_phospholipids_eicosanoid_synthesis_and_plasma_lipids_in_nephrotic_rats_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0024-4201&date=1988&volume=23&issue=11&spage=1059 DB - PRIME DP - Unbound Medicine ER -