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Chemical Characterization and Biological Activity of the Mastic Gum Essential Oils of Pistacia lentiscus Var. Chia from Turkey.
Molecules. 2020 May 02; 25(9)M

Abstract

The essential oils (EOs) were isolated by hydrodistillation from wild and cultivated Pistacia lentiscus L. var. chia-mastic gum tree (Anacardiaceae) from two natural habitats, namely from Cesme-Uzunkoy (1) and Mordogan (2), and one cultivated source, Cesme-Germiyan (3), in Izmir, Turkey. This comparative study evaluated the chemical composition and biological activity of mastic gum essential oils (MGEOs). For this purpose, MGEOs 1-3 were analyzed by gas chromatography-flame ionization detection (GC-FID), gas chromatography-mass spectrometry (GC-MS), and chiral GC for α-pinene. Laboratory assays were conducted to assess for potential in vitro cytotoxicity (multiple in vitro cancer cell lines), antimicrobial properties (five bacterial species and yeast), anti-inflammatory activity (inhibition of inducible nitric oxide synthase, iNOS), and the attraction of Ceratitis capitata (Mediterranean fruit fly, medfly), respectively. Chemical analysis indicated that MGEOs 1 and 2 were rich in α-pinene (56.2% and 51.9%), myrcene (20.1% and 18.6%), and β-pinene (2.7% and 3.1%), respectively; whereas MGEO-3 was characterized by a high level of α-pinene (70.8%), followed by β-pinene (5.7%) and myrcene (2.5%). Chiral GC analyses showed that concentration ratios between (-)/(+)-α-pinene and (-)-α-pinene/myrcene allowed for differentiation between wild and cultivated MGEO sources. In biological assays, MGEOs 1-3 did not exhibit significant antimicrobial effects against the pathogens evaluated and were not strong attractants of male medflies; however, all three MGEOs displayed a dose-dependent inhibition of iNOS, and MGEOs 1 and 2 exhibited selective in vitro cytotoxicity against human cancer cells. These results suggest that wild-type mastic gum oils from Cesme and Mordogan (MGEOs 1 and 2) are potential sources of beneficial products and warrant further investigation.

Authors+Show Affiliations

United States Department of Agriculture, Agricultural Research Service, Subtropical Horticulture Research Station (SHRS), Miami, FL 33158, USA.Department of Bioengineering, Faculty of Engineering, Ege University, Bornova, Izmir 35100, Turkey.United States Department of Agriculture, Agricultural Research Service, Subtropical Horticulture Research Station (SHRS), Miami, FL 33158, USA.Department of Pharmacognosy, Faculty of Pharmacy, Anadolu University, Eskisehir 26470, Turkey. Faculty of Pharmacy, Eastern Mediterranean University, Famagusta 99628, Cyprus.Department of Pharmacognosy, Faculty of Pharmacy, Anadolu University, Eskisehir 26470, Turkey.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32370246

Citation

Tabanca, Nurhayat, et al. "Chemical Characterization and Biological Activity of the Mastic Gum Essential Oils of Pistacia Lentiscus Var. Chia From Turkey." Molecules (Basel, Switzerland), vol. 25, no. 9, 2020.
Tabanca N, Nalbantsoy A, Kendra PE, et al. Chemical Characterization and Biological Activity of the Mastic Gum Essential Oils of Pistacia lentiscus Var. Chia from Turkey. Molecules. 2020;25(9).
Tabanca, N., Nalbantsoy, A., Kendra, P. E., Demirci, F., & Demirci, B. (2020). Chemical Characterization and Biological Activity of the Mastic Gum Essential Oils of Pistacia lentiscus Var. Chia from Turkey. Molecules (Basel, Switzerland), 25(9). https://doi.org/10.3390/molecules25092136
Tabanca N, et al. Chemical Characterization and Biological Activity of the Mastic Gum Essential Oils of Pistacia Lentiscus Var. Chia From Turkey. Molecules. 2020 May 2;25(9) PubMed PMID: 32370246.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chemical Characterization and Biological Activity of the Mastic Gum Essential Oils of Pistacia lentiscus Var. Chia from Turkey. AU - Tabanca,Nurhayat, AU - Nalbantsoy,Ayse, AU - Kendra,Paul E, AU - Demirci,Fatih, AU - Demirci,Betul, Y1 - 2020/05/02/ PY - 2020/04/07/received PY - 2020/04/30/revised PY - 2020/05/01/accepted PY - 2020/5/7/entrez PY - 2020/5/7/pubmed PY - 2021/2/12/medline KW - Anacardiaceae KW - GC-MS KW - Mediterranean fruit fly KW - antimicrobial KW - bioactivity KW - chiral-GC KW - cytotoxicity KW - myrcene KW - terpenoids KW - α-pinene KW - β-pinene JF - Molecules (Basel, Switzerland) JO - Molecules VL - 25 IS - 9 N2 - The essential oils (EOs) were isolated by hydrodistillation from wild and cultivated Pistacia lentiscus L. var. chia-mastic gum tree (Anacardiaceae) from two natural habitats, namely from Cesme-Uzunkoy (1) and Mordogan (2), and one cultivated source, Cesme-Germiyan (3), in Izmir, Turkey. This comparative study evaluated the chemical composition and biological activity of mastic gum essential oils (MGEOs). For this purpose, MGEOs 1-3 were analyzed by gas chromatography-flame ionization detection (GC-FID), gas chromatography-mass spectrometry (GC-MS), and chiral GC for α-pinene. Laboratory assays were conducted to assess for potential in vitro cytotoxicity (multiple in vitro cancer cell lines), antimicrobial properties (five bacterial species and yeast), anti-inflammatory activity (inhibition of inducible nitric oxide synthase, iNOS), and the attraction of Ceratitis capitata (Mediterranean fruit fly, medfly), respectively. Chemical analysis indicated that MGEOs 1 and 2 were rich in α-pinene (56.2% and 51.9%), myrcene (20.1% and 18.6%), and β-pinene (2.7% and 3.1%), respectively; whereas MGEO-3 was characterized by a high level of α-pinene (70.8%), followed by β-pinene (5.7%) and myrcene (2.5%). Chiral GC analyses showed that concentration ratios between (-)/(+)-α-pinene and (-)-α-pinene/myrcene allowed for differentiation between wild and cultivated MGEO sources. In biological assays, MGEOs 1-3 did not exhibit significant antimicrobial effects against the pathogens evaluated and were not strong attractants of male medflies; however, all three MGEOs displayed a dose-dependent inhibition of iNOS, and MGEOs 1 and 2 exhibited selective in vitro cytotoxicity against human cancer cells. These results suggest that wild-type mastic gum oils from Cesme and Mordogan (MGEOs 1 and 2) are potential sources of beneficial products and warrant further investigation. SN - 1420-3049 UR - https://www.unboundmedicine.com/medline/citation/32370246/Chemical_Characterization_and_Biological_Activity_of_the_Mastic_Gum_Essential_Oils_of_Pistacia_lentiscus_Var__Chia_from_Turkey_ DB - PRIME DP - Unbound Medicine ER -