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EBV-associated lymphoid interstitial pneumonia in IBD patient: Case report and literature review.
Respir Med Case Rep. 2020; 30:101059.RM

Abstract

Background

Lymphoid interstitial pneumonia (LIP) is categorized as a rare form of interstitial lung disease. Most cases are associated with autoimmune disease.

Case report

A 78-year-old male with Crohn's disease, presented with progressive dyspnea and dry cough for few weeks. The pathology of transbronchial lung biopsy was compatible with LIP and positive cells on EBER in situ hybridization. Blood EBV viral load was 85,715 copies/mL, compatible with EBV-associated LIP. All immunosuppressive agents were discontinued, but unfortunately the patient died due to hospital-acquired infections. In addition, we reviewed all reported cases of EBV-associated LIP in literature.

Conclusions

To our knowledge, we report herein the first case of EBV-associated LIP in an IBD patient. We postulate that LIP was the consequence from EBV reactivation, probably due to immunosuppressive agents and/or IBD itself. The physician should aware of this disease when taking care of immunosuppressive patients who present with acute interstitial pneumonitis.

Authors+Show Affiliations

Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.Department of Pathology, Chulalongkorn University, Bangkok, Thailand.Department of Pathology, Chulalongkorn University, Bangkok, Thailand.Division of Infectious Diseases, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Pub Type(s)

Case Reports

Language

eng

PubMed ID

32373453

Citation

Prasoppokakorn, Thaninee, et al. "EBV-associated Lymphoid Interstitial Pneumonia in IBD Patient: Case Report and Literature Review." Respiratory Medicine Case Reports, vol. 30, 2020, p. 101059.
Prasoppokakorn T, Assanasen T, Chantranuwatana P, et al. EBV-associated lymphoid interstitial pneumonia in IBD patient: Case report and literature review. Respir Med Case Rep. 2020;30:101059.
Prasoppokakorn, T., Assanasen, T., Chantranuwatana, P., & Suankratay, C. (2020). EBV-associated lymphoid interstitial pneumonia in IBD patient: Case report and literature review. Respiratory Medicine Case Reports, 30, 101059. https://doi.org/10.1016/j.rmcr.2020.101059
Prasoppokakorn T, et al. EBV-associated Lymphoid Interstitial Pneumonia in IBD Patient: Case Report and Literature Review. Respir Med Case Rep. 2020;30:101059. PubMed PMID: 32373453.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - EBV-associated lymphoid interstitial pneumonia in IBD patient: Case report and literature review. AU - Prasoppokakorn,Thaninee, AU - Assanasen,Thammathorn, AU - Chantranuwatana,Poonchavist, AU - Suankratay,Chusana, Y1 - 2020/04/18/ PY - 2020/01/06/received PY - 2020/04/03/revised PY - 2020/04/11/accepted PY - 2020/5/7/entrez PY - 2020/5/7/pubmed PY - 2020/5/7/medline KW - EBV-Associated lymphoid interstitial pneumonia KW - Epstein-barr virus KW - Inflammatory bowel disease KW - Pulmonary lymphoproliferative disorder SP - 101059 EP - 101059 JF - Respiratory medicine case reports JO - Respir Med Case Rep VL - 30 N2 - Background: Lymphoid interstitial pneumonia (LIP) is categorized as a rare form of interstitial lung disease. Most cases are associated with autoimmune disease. Case report: A 78-year-old male with Crohn's disease, presented with progressive dyspnea and dry cough for few weeks. The pathology of transbronchial lung biopsy was compatible with LIP and positive cells on EBER in situ hybridization. Blood EBV viral load was 85,715 copies/mL, compatible with EBV-associated LIP. All immunosuppressive agents were discontinued, but unfortunately the patient died due to hospital-acquired infections. In addition, we reviewed all reported cases of EBV-associated LIP in literature. Conclusions: To our knowledge, we report herein the first case of EBV-associated LIP in an IBD patient. We postulate that LIP was the consequence from EBV reactivation, probably due to immunosuppressive agents and/or IBD itself. The physician should aware of this disease when taking care of immunosuppressive patients who present with acute interstitial pneumonitis. SN - 2213-0071 UR - https://www.unboundmedicine.com/medline/citation/32373453/EBV-associated_lymphoid_interstitial_pneumonia_in_IBD_patient:_Case_report_and_literature_review L2 - https://linkinghub.elsevier.com/retrieve/pii/S2213-0071(20)30013-7 DB - PRIME DP - Unbound Medicine ER -
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