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Sensor-based characterization of daily walking: a new paradigm in pre-frailty/frailty assessment.
BMC Geriatr. 2020 05 06; 20(1):164.BG

Abstract

BACKGROUND

Frailty is a highly recognized geriatric syndrome resulting in decline in reserve across multiple physiological systems. Impaired physical function is one of the major indicators of frailty. The goal of this study was to evaluate an algorithm that discriminates between frailty groups (non-frail and pre-frail/frail) based on gait performance parameters derived from unsupervised daily physical activity (DPA).

METHODS

DPA was acquired for 48 h from older adults (≥65 years) using a tri-axial accelerometer motion-sensor. Continuous bouts of walking for 20s, 30s, 40s, 50s and 60s without pauses were identified from acceleration data. These were then used to extract qualitative measures (gait variability, gait asymmetry, and gait irregularity) and quantitative measures (total continuous walking duration and maximum number of continuous steps) to characterize gait performance. Association between frailty and gait performance parameters was assessed using multinomial logistic models with frailty as the dependent variable, and gait performance parameters along with demographic parameters as independent variables.

RESULTS

One hundred twenty-six older adults (44 non-frail, 60 pre-frail, and 22 frail, based on the Fried index) were recruited. Step- and stride-times, frequency domain gait variability, and continuous walking quantitative measures were significantly different between non-frail and pre-frail/frail groups (p < 0.05). Among the five different durations (20s, 30s, 40s, 50s and 60s), gait performance parameters extracted from 60s continuous walks provided the best frailty assessment results. Using the 60s gait performance parameters in the logistic model, pre-frail/frail group (vs. non-frail) was identified with 76.8% sensitivity and 80% specificity.

DISCUSSION

Everyday walking characteristics were found to be associated with frailty. Along with quantitative measures of physical activity, qualitative measures are critical elements representing the early stages of frailty. In-home gait assessment offers an opportunity to screen for and monitor frailty.

TRIAL REGISTRATION

The clinical trial was retrospectively registered on June 18th, 2013 with ClinicalTrials.gov, identifier NCT01880229.

Authors+Show Affiliations

Department of Biomedical Engineering, University of Arizona, Tucson, AZ, USA.Department of Biomedical Engineering, University of Arizona, Tucson, AZ, USA. ntoosizadeh@aging.arizona.edu. Arizona Center on Aging, Department of Medicine, University of Arizona, Tucson, AZ, USA. ntoosizadeh@aging.arizona.edu.Department of Biomedical Engineering, University of Arizona, Tucson, AZ, USA. Arizona Center on Aging, Department of Medicine, University of Arizona, Tucson, AZ, USA.Arizona Center on Aging, Department of Medicine, University of Arizona, Tucson, AZ, USA.Department of Biomedical Engineering, University of Arizona, Tucson, AZ, USA.Department of Biomedical Engineering, University of Arizona, Tucson, AZ, USA. Department of Aerospace and Mechanical Engineering, University of Arizona, Tucson, AZ, USA.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

32375700

Citation

Pradeep Kumar, Danya, et al. "Sensor-based Characterization of Daily Walking: a New Paradigm in Pre-frailty/frailty Assessment." BMC Geriatrics, vol. 20, no. 1, 2020, p. 164.
Pradeep Kumar D, Toosizadeh N, Mohler J, et al. Sensor-based characterization of daily walking: a new paradigm in pre-frailty/frailty assessment. BMC Geriatr. 2020;20(1):164.
Pradeep Kumar, D., Toosizadeh, N., Mohler, J., Ehsani, H., Mannier, C., & Laksari, K. (2020). Sensor-based characterization of daily walking: a new paradigm in pre-frailty/frailty assessment. BMC Geriatrics, 20(1), 164. https://doi.org/10.1186/s12877-020-01572-1
Pradeep Kumar D, et al. Sensor-based Characterization of Daily Walking: a New Paradigm in Pre-frailty/frailty Assessment. BMC Geriatr. 2020 05 6;20(1):164. PubMed PMID: 32375700.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sensor-based characterization of daily walking: a new paradigm in pre-frailty/frailty assessment. AU - Pradeep Kumar,Danya, AU - Toosizadeh,Nima, AU - Mohler,Jane, AU - Ehsani,Hossein, AU - Mannier,Cassidy, AU - Laksari,Kaveh, Y1 - 2020/05/06/ PY - 2019/09/17/received PY - 2020/04/28/accepted PY - 2020/5/8/entrez PY - 2020/5/8/pubmed PY - 2020/12/22/medline KW - Continuous walking KW - Daily physical activity KW - Frailty KW - Performance parameters KW - Wearable sensors SP - 164 EP - 164 JF - BMC geriatrics JO - BMC Geriatr VL - 20 IS - 1 N2 - BACKGROUND: Frailty is a highly recognized geriatric syndrome resulting in decline in reserve across multiple physiological systems. Impaired physical function is one of the major indicators of frailty. The goal of this study was to evaluate an algorithm that discriminates between frailty groups (non-frail and pre-frail/frail) based on gait performance parameters derived from unsupervised daily physical activity (DPA). METHODS: DPA was acquired for 48 h from older adults (≥65 years) using a tri-axial accelerometer motion-sensor. Continuous bouts of walking for 20s, 30s, 40s, 50s and 60s without pauses were identified from acceleration data. These were then used to extract qualitative measures (gait variability, gait asymmetry, and gait irregularity) and quantitative measures (total continuous walking duration and maximum number of continuous steps) to characterize gait performance. Association between frailty and gait performance parameters was assessed using multinomial logistic models with frailty as the dependent variable, and gait performance parameters along with demographic parameters as independent variables. RESULTS: One hundred twenty-six older adults (44 non-frail, 60 pre-frail, and 22 frail, based on the Fried index) were recruited. Step- and stride-times, frequency domain gait variability, and continuous walking quantitative measures were significantly different between non-frail and pre-frail/frail groups (p < 0.05). Among the five different durations (20s, 30s, 40s, 50s and 60s), gait performance parameters extracted from 60s continuous walks provided the best frailty assessment results. Using the 60s gait performance parameters in the logistic model, pre-frail/frail group (vs. non-frail) was identified with 76.8% sensitivity and 80% specificity. DISCUSSION: Everyday walking characteristics were found to be associated with frailty. Along with quantitative measures of physical activity, qualitative measures are critical elements representing the early stages of frailty. In-home gait assessment offers an opportunity to screen for and monitor frailty. TRIAL REGISTRATION: The clinical trial was retrospectively registered on June 18th, 2013 with ClinicalTrials.gov, identifier NCT01880229. SN - 1471-2318 UR - https://www.unboundmedicine.com/medline/citation/32375700/Sensor_based_characterization_of_daily_walking:_a_new_paradigm_in_pre_frailty/frailty_assessment_ L2 - https://bmcgeriatr.biomedcentral.com/articles/10.1186/s12877-020-01572-1 DB - PRIME DP - Unbound Medicine ER -