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Insights on chemical-biological correlations learned from investigations on the sulfated galactan from the marine alga Bothryocladia occidentalis.
Int J Biol Macromol. 2020 May 03; 158:471-476.IJ

Abstract

Marine organisms have been proven to be a valuable source of bioactive compounds. Among them, we highlight the sulfated galactans (SGs) from seaweeds, which besides being massively exploited as industrial thickening and gelling agents (agarans and carrageenans), have also shown promising pharmacological properties. Investigations on the non-agaran/-carrageenan SG from the red algae Bothryocladia occidentalis (SGBo) have demonstrated clear correlations between physical-chemical features and biological activities. SGBo is composed of 2,3-disulfated (~33%) or 2-sulfated (33%) α-D-galactose linked to non- or 2-sulfated β-D-galactose repetitive disaccharide units. The notable serpin-dependent/-independent anticoagulant activity of SGBo (~130 international units [IU]/mg) is higher than those of other SGs containing less 2,3-disulfated α-D-galactose units and their low-molecular-weight derivatives, and thus is directly correlated to its high molecular mass (>200 kDa) and sulfation pattern. Although SGBo has antithrombotic efficacy equivalent to heparin and decreased bleeding potential at low-doses, high-doses substantially increase thrombus formation in animal models. Such an odd dose-dependent dual antithrombotic/prothrombotic activity has been attributed to the ability of SGBo to activate factor XII. In addition to anticoagulant properties, SGBo also exerts antimalarial, antileishmanial and antiophidic activities, and, therefore, has a remarkable potential for the research and development of novel drugs.

Authors+Show Affiliations

Laboratório Integrado de Prospecção em Produtos Bioativos, Campus Professor Aloisio Teixeira, Universidade Federal do Rio de Janeiro, Macaé 27930-560, Brazil.Laboratório Integrado de Prospecção em Produtos Bioativos, Campus Professor Aloisio Teixeira, Universidade Federal do Rio de Janeiro, Macaé 27930-560, Brazil.Laboratório Integrado de Prospecção em Produtos Bioativos, Campus Professor Aloisio Teixeira, Universidade Federal do Rio de Janeiro, Macaé 27930-560, Brazil.Laboratório de Tecnologia Industrial Farmacêutica, Departamento de Medicamentos, Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-599, Brazil.Laboratório de Tecnologia Industrial Farmacêutica, Departamento de Medicamentos, Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-599, Brazil.Laboratório de Tecido Conjuntivo, Instituto de Bioquímica Médica Leopoldo de Meis and Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-913, Brazil.Laboratório de Tecido Conjuntivo, Instituto de Bioquímica Médica Leopoldo de Meis and Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-913, Brazil. Electronic address: evilanova@hucff.ufrj.br.Laboratório Integrado de Prospecção em Produtos Bioativos, Campus Professor Aloisio Teixeira, Universidade Federal do Rio de Janeiro, Macaé 27930-560, Brazil. Electronic address: leopcinelli@gmail.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32376249

Citation

Sampaio, Thamiris B P., et al. "Insights On Chemical-biological Correlations Learned From Investigations On the Sulfated Galactan From the Marine Alga Bothryocladia Occidentalis." International Journal of Biological Macromolecules, vol. 158, 2020, pp. 471-476.
Sampaio TBP, Costa BB, Moreira TA, et al. Insights on chemical-biological correlations learned from investigations on the sulfated galactan from the marine alga Bothryocladia occidentalis. Int J Biol Macromol. 2020;158:471-476.
Sampaio, T. B. P., Costa, B. B., Moreira, T. A., Cabral, L. M., Silva, L. C. R. P., Mourão, P. A. S., Vilanova, E., & Cinelli, L. P. (2020). Insights on chemical-biological correlations learned from investigations on the sulfated galactan from the marine alga Bothryocladia occidentalis. International Journal of Biological Macromolecules, 158, 471-476. https://doi.org/10.1016/j.ijbiomac.2020.04.085
Sampaio TBP, et al. Insights On Chemical-biological Correlations Learned From Investigations On the Sulfated Galactan From the Marine Alga Bothryocladia Occidentalis. Int J Biol Macromol. 2020 May 3;158:471-476. PubMed PMID: 32376249.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Insights on chemical-biological correlations learned from investigations on the sulfated galactan from the marine alga Bothryocladia occidentalis. AU - Sampaio,Thamiris B P, AU - Costa,Bianca B, AU - Moreira,Thamyris A, AU - Cabral,Lucio M, AU - Silva,Luiz C R P, AU - Mourão,Paulo A S, AU - Vilanova,Eduardo, AU - Cinelli,Leonardo P, Y1 - 2020/05/03/ PY - 2020/03/06/received PY - 2020/04/02/revised PY - 2020/04/12/accepted PY - 2020/5/8/pubmed PY - 2020/5/8/medline PY - 2020/5/8/entrez KW - Anticoagulants KW - Marine drugs KW - Sulfated polysaccharides SP - 471 EP - 476 JF - International journal of biological macromolecules JO - Int J Biol Macromol VL - 158 N2 - Marine organisms have been proven to be a valuable source of bioactive compounds. Among them, we highlight the sulfated galactans (SGs) from seaweeds, which besides being massively exploited as industrial thickening and gelling agents (agarans and carrageenans), have also shown promising pharmacological properties. Investigations on the non-agaran/-carrageenan SG from the red algae Bothryocladia occidentalis (SGBo) have demonstrated clear correlations between physical-chemical features and biological activities. SGBo is composed of 2,3-disulfated (~33%) or 2-sulfated (33%) α-D-galactose linked to non- or 2-sulfated β-D-galactose repetitive disaccharide units. The notable serpin-dependent/-independent anticoagulant activity of SGBo (~130 international units [IU]/mg) is higher than those of other SGs containing less 2,3-disulfated α-D-galactose units and their low-molecular-weight derivatives, and thus is directly correlated to its high molecular mass (>200 kDa) and sulfation pattern. Although SGBo has antithrombotic efficacy equivalent to heparin and decreased bleeding potential at low-doses, high-doses substantially increase thrombus formation in animal models. Such an odd dose-dependent dual antithrombotic/prothrombotic activity has been attributed to the ability of SGBo to activate factor XII. In addition to anticoagulant properties, SGBo also exerts antimalarial, antileishmanial and antiophidic activities, and, therefore, has a remarkable potential for the research and development of novel drugs. SN - 1879-0003 UR - https://www.unboundmedicine.com/medline/citation/32376249/Insights_on_chemical_biological_correlations_learned_from_investigations_on_the_sulfated_galactan_from_the_marine_alga_Bothryocladia_occidentalis_ DB - PRIME DP - Unbound Medicine ER -
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