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Evidence for and against vertical transmission for severe acute respiratory syndrome coronavirus 2.
Am J Obstet Gynecol. 2020 07; 223(1):91.e1-91.e4.AJ

Abstract

COVID-19 can severely affect pregnant women Furthermore, issues regarding vertical transmission of severe acute respiratory syndrome coronavirus 2 are emerging. In patients and neonates who are showing symptoms of coronavirus disease 2019, real-time polymerase chain reaction of nasal and throat swabs, sputum, and feces is performed to detect the presence of severe acute respiratory syndrome coronavirus 2. In addition, real-time polymerase chain reaction of vaginal swabs, amniotic fluid, placenta, cord blood, neonatal blood, or breast milk for the detection of severe acute respiratory syndrome coronavirus 2 did not show substantial results. Viremia was present in 1% of adult patients who were showing symptoms of coronavirus disease 2019. Here, we reviewed 12 articles published between Feb. 10, 2020, and April 4, 2020, that reported on 68 deliveries and 71 neonates with maternal infection in the third trimester of pregnancy. To determine whether infection occurred congenitally or perinatally, perinatal exposure, mode of delivery, and time interval from delivery to the diagnosis of neonatal infection were considered. Neonates with severe acute respiratory syndrome coronavirus 2 infection are usually asymptomatic. In 4 cases, a diagnostic test for severe acute respiratory syndrome coronavirus 2 infection was performed within 48 hours of life. Furthermore, detection rates of real-time polymerase chain reaction and the interpretation of immunoglobulin M and immunoglobulin G antibodies levels in cord and neonatal blood were discussed in relation with the immaturity of the fetal and neonatal immune system.

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Authors+Show Affiliations

Lamouroux A
Department of Fetal Pathology and Genetics, Nimes and Montpellier University Hospitals, University of Montpellier, Montpellier, France.
Attie-Bitach T
Department of Embryology, Fetal Pathology, and Genetics, Imagine Institute, Necker-Enfants Malades Hospital, University of Paris, Paris, France.
Martinovic J
Department of Fetal Pathology, Antoine-Béclère Hospital, Paris Saclay University, Clamart, France.
Leruez-Ville M
Departments of Medical Virology, Necker-Enfants Malades Hospital, University of Paris, Paris, France.
Ville Y
Obstetrics and Fetal Medicine, Necker-Enfants Malades Hospital, University of Paris, Paris, France. Electronic address: ville.yves@gmail.com.

MeSH

Amniotic FluidBetacoronavirusCOVID-19Cesarean SectionCoronavirus InfectionsFemaleHumansInfant, NewbornInfectious Disease Transmission, VerticalPandemicsPlacentaPneumonia, ViralPregnancyPregnancy Complications, InfectiousSARS-CoV-2

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32376317

Citation

Lamouroux, Audrey, et al. "Evidence for and Against Vertical Transmission for Severe Acute Respiratory Syndrome Coronavirus 2." American Journal of Obstetrics and Gynecology, vol. 223, no. 1, 2020, pp. 91.e1-91.e4.
Lamouroux A, Attie-Bitach T, Martinovic J, et al. Evidence for and against vertical transmission for severe acute respiratory syndrome coronavirus 2. Am J Obstet Gynecol. 2020;223(1):91.e1-91.e4.
Lamouroux, A., Attie-Bitach, T., Martinovic, J., Leruez-Ville, M., & Ville, Y. (2020). Evidence for and against vertical transmission for severe acute respiratory syndrome coronavirus 2. American Journal of Obstetrics and Gynecology, 223(1), e1-e4. https://doi.org/10.1016/j.ajog.2020.04.039
Lamouroux A, et al. Evidence for and Against Vertical Transmission for Severe Acute Respiratory Syndrome Coronavirus 2. Am J Obstet Gynecol. 2020;223(1):91.e1-91.e4. PubMed PMID: 32376317.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evidence for and against vertical transmission for severe acute respiratory syndrome coronavirus 2. AU - Lamouroux,Audrey, AU - Attie-Bitach,Tania, AU - Martinovic,Jelena, AU - Leruez-Ville,Marianne, AU - Ville,Yves, Y1 - 2020/05/04/ PY - 2020/5/8/pubmed PY - 2020/7/11/medline PY - 2020/5/8/entrez KW - fetus KW - immunoglobulin G KW - immunoglobulin M KW - placenta KW - real-time polymerase chain reaction KW - severe acute respiratory syndrome coronavirus 2 SP - 91.e1 EP - 91.e4 JF - American journal of obstetrics and gynecology JO - Am J Obstet Gynecol VL - 223 IS - 1 N2 - COVID-19 can severely affect pregnant women Furthermore, issues regarding vertical transmission of severe acute respiratory syndrome coronavirus 2 are emerging. In patients and neonates who are showing symptoms of coronavirus disease 2019, real-time polymerase chain reaction of nasal and throat swabs, sputum, and feces is performed to detect the presence of severe acute respiratory syndrome coronavirus 2. In addition, real-time polymerase chain reaction of vaginal swabs, amniotic fluid, placenta, cord blood, neonatal blood, or breast milk for the detection of severe acute respiratory syndrome coronavirus 2 did not show substantial results. Viremia was present in 1% of adult patients who were showing symptoms of coronavirus disease 2019. Here, we reviewed 12 articles published between Feb. 10, 2020, and April 4, 2020, that reported on 68 deliveries and 71 neonates with maternal infection in the third trimester of pregnancy. To determine whether infection occurred congenitally or perinatally, perinatal exposure, mode of delivery, and time interval from delivery to the diagnosis of neonatal infection were considered. Neonates with severe acute respiratory syndrome coronavirus 2 infection are usually asymptomatic. In 4 cases, a diagnostic test for severe acute respiratory syndrome coronavirus 2 infection was performed within 48 hours of life. Furthermore, detection rates of real-time polymerase chain reaction and the interpretation of immunoglobulin M and immunoglobulin G antibodies levels in cord and neonatal blood were discussed in relation with the immaturity of the fetal and neonatal immune system. SN - 1097-6868 UR - https://www.unboundmedicine.com/medline/citation/32376317/Evidence_for_and_against_vertical_transmission_for_severe_acute_respiratory_syndrome_coronavirus_2_ DB - PRIME DP - Unbound Medicine ER -