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[Chromosomal polymorphisms are associated with blastomere multinucleation in IVF/ICSI cycles].
Nan Fang Yi Ke Da Xue Xue Bao. 2020 Jan 30; 40(1):73-78.NF

Abstract

OBJECTIVE

To investigate the association of chromosomal polymorphisms with multinucleated embryos in infertile couples undergoing in vitro fertilization-intracytoplasmic sperm injection (IVF-ICSI).

METHODS

This retrospective case-control study was conducted among 1145 infertile couples undergoing their first IVF/ICSI cycles. According to their karyotype, the couples were divided into chromosomal polymorphism group and control group, and the former group was divided into 3 subgroups: inversion group, D and G genome polymorphic group and 1, 9, and 16 qh+group. The blastomere multinucleation rate, clinical pregnancy rate and live birth rate were compared between the groups.

RESULTS

Of the total of 1145 couples, 139 (6.10%) had chromosomal polymorphisms at least in one partner. No significant differences were found in female age, BMI, basal FSH level, total gonadotropin dose, E2 level on day of HCG, number of oocytes retrieved, fertilization rate, top quality embryo rate, clinical pregnancy rate or live birth rate among the groups (P > 0.05). The multinuclear rate of the embryos in couples with pericentric inversion of chromosomes 1, 9, and Y chromosomes and those with D and G genome polymorphisms were 8.23% and 4.65%, respectively, significantly higher than that in the control group (2.69%; P < 0.05); the multinuclear rate of the embryos was 2.77% in 1, 9, and 16 qh+ group, similar with that in the control group (P > 0.05).

CONCLUSIONS

Infertile couples with pericentric inversion of chromosomes 1, 9, and Y chromosomes and in those with D and G genome polymorphism are at higher risks of blastomere multinucleation in IVF- ICSI cycles; 1, 9, and 16 qh + polymorphisms do not increase the rate of blastomere multinucleation of the embryos.

Authors+Show Affiliations

Center of Reproductive Medicine, Guangzhou Women and Children's Medical Center, Guangzhou 510623, China.Center of Reproductive Medicine, Guangzhou Women and Children's Medical Center, Guangzhou 510623, China.Prenatal Diagnosis Center, Guangzhou Women and Children's Medical Center, Guangzhou 510623, China.Center of Reproductive Medicine, Guangzhou Women and Children's Medical Center, Guangzhou 510623, China.Center of Reproductive Medicine, Guangzhou Women and Children's Medical Center, Guangzhou 510623, China.

Pub Type(s)

Journal Article

Language

chi

PubMed ID

32376550

Citation

Chen, Zhiheng, et al. "[Chromosomal Polymorphisms Are Associated With Blastomere Multinucleation in IVF/ICSI Cycles]." Nan Fang Yi Ke Da Xue Xue Bao = Journal of Southern Medical University, vol. 40, no. 1, 2020, pp. 73-78.
Chen Z, Yang L, Yi C, et al. [Chromosomal polymorphisms are associated with blastomere multinucleation in IVF/ICSI cycles]. Nan Fang Yi Ke Da Xue Xue Bao. 2020;40(1):73-78.
Chen, Z., Yang, L., Yi, C., Liu, J., & Sun, L. (2020). [Chromosomal polymorphisms are associated with blastomere multinucleation in IVF/ICSI cycles]. Nan Fang Yi Ke Da Xue Xue Bao = Journal of Southern Medical University, 40(1), 73-78. https://doi.org/10.12122/j.issn.1673-4254.2020.01.12
Chen Z, et al. [Chromosomal Polymorphisms Are Associated With Blastomere Multinucleation in IVF/ICSI Cycles]. Nan Fang Yi Ke Da Xue Xue Bao. 2020 Jan 30;40(1):73-78. PubMed PMID: 32376550.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Chromosomal polymorphisms are associated with blastomere multinucleation in IVF/ICSI cycles]. AU - Chen,Zhiheng, AU - Yang,Li, AU - Yi,Cuiqing, AU - Liu,Jun, AU - Sun,Ling, PY - 2020/5/8/entrez PY - 2020/5/8/pubmed PY - 2020/5/8/medline KW - chromosomal polymorphism KW - in vitro fertilization-intracytoplasmic sperm injection KW - multinucleated embryos KW - pregnancy outcome SP - 73 EP - 78 JF - Nan fang yi ke da xue xue bao = Journal of Southern Medical University JO - Nan Fang Yi Ke Da Xue Xue Bao VL - 40 IS - 1 N2 - OBJECTIVE: To investigate the association of chromosomal polymorphisms with multinucleated embryos in infertile couples undergoing in vitro fertilization-intracytoplasmic sperm injection (IVF-ICSI). METHODS: This retrospective case-control study was conducted among 1145 infertile couples undergoing their first IVF/ICSI cycles. According to their karyotype, the couples were divided into chromosomal polymorphism group and control group, and the former group was divided into 3 subgroups: inversion group, D and G genome polymorphic group and 1, 9, and 16 qh+group. The blastomere multinucleation rate, clinical pregnancy rate and live birth rate were compared between the groups. RESULTS: Of the total of 1145 couples, 139 (6.10%) had chromosomal polymorphisms at least in one partner. No significant differences were found in female age, BMI, basal FSH level, total gonadotropin dose, E2 level on day of HCG, number of oocytes retrieved, fertilization rate, top quality embryo rate, clinical pregnancy rate or live birth rate among the groups (P > 0.05). The multinuclear rate of the embryos in couples with pericentric inversion of chromosomes 1, 9, and Y chromosomes and those with D and G genome polymorphisms were 8.23% and 4.65%, respectively, significantly higher than that in the control group (2.69%; P < 0.05); the multinuclear rate of the embryos was 2.77% in 1, 9, and 16 qh+ group, similar with that in the control group (P > 0.05). CONCLUSIONS: Infertile couples with pericentric inversion of chromosomes 1, 9, and Y chromosomes and in those with D and G genome polymorphism are at higher risks of blastomere multinucleation in IVF- ICSI cycles; 1, 9, and 16 qh + polymorphisms do not increase the rate of blastomere multinucleation of the embryos. SN - 1673-4254 UR - https://www.unboundmedicine.com/medline/citation/32376550/[Chromosomal_polymorphisms_are_associated_with_blastomere_multinucleation_in_IVF/ICSI_cycles] L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/32376550/ DB - PRIME DP - Unbound Medicine ER -