Tags

Type your tag names separated by a space and hit enter

Behavioral and neural correlates of postnatal olfactory conditioning: I. Effect of respiration on conditioned neural responses.
Physiol Behav. 1988; 44(1):85-90.PB

Abstract

Following olfactory classical conditioning, infant rats exhibit a preference for the conditioned odor and exhibit enhanced uptake of focal 14C 2-deoxyglucose (2-DG) within the olfactory bulb. The present experiments assessed the role of respiration on the expression of the enhanced 2-DG uptake response. Pups were conditioned from postnatal day (PN) 1-18 with an olfactory stimulus paired with a reinforcing tactile stimulus which mimics maternal contact (Odor-Stroke). Control pups received odor only or tactile stimulation only. On PN 19, pups received 1 of 3 tests: 1) a two-odor choice test, 2) an odor/2-DG test with normal respiration allowed, or 3) an odor/2-DG test with respiration experimentally controlled. The results indicated that: 1) Odor-Stroke pups learned the conditioned odor preference, 2) Odor-Stroke, normally respiring pups exhibited enhanced olfactory bulb 2-DG uptake when compared to control pups. No difference in respiration rate was detected between groups in normally respiring pups. 3) Odor Stroke pups whose breathing was experimentally controlled exhibited enhanced olfactory bulb 2-DG uptake when compared to control pups with an identical number of respirations. Together, these results demonstrate that modified respiration during testing is not required for the expression of a modified olfactory bulb response to learned attractive odors. Therefore, the data suggest that the olfactory system itself is modified by early learning.

Authors+Show Affiliations

Department of Psychobiology, University of California, Irvine 92717.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

3237818

Citation

Sullivan, R M., et al. "Behavioral and Neural Correlates of Postnatal Olfactory Conditioning: I. Effect of Respiration On Conditioned Neural Responses." Physiology & Behavior, vol. 44, no. 1, 1988, pp. 85-90.
Sullivan RM, Wilson DA, Kim MH, et al. Behavioral and neural correlates of postnatal olfactory conditioning: I. Effect of respiration on conditioned neural responses. Physiol Behav. 1988;44(1):85-90.
Sullivan, R. M., Wilson, D. A., Kim, M. H., & Leon, M. (1988). Behavioral and neural correlates of postnatal olfactory conditioning: I. Effect of respiration on conditioned neural responses. Physiology & Behavior, 44(1), 85-90.
Sullivan RM, et al. Behavioral and Neural Correlates of Postnatal Olfactory Conditioning: I. Effect of Respiration On Conditioned Neural Responses. Physiol Behav. 1988;44(1):85-90. PubMed PMID: 3237818.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Behavioral and neural correlates of postnatal olfactory conditioning: I. Effect of respiration on conditioned neural responses. AU - Sullivan,R M, AU - Wilson,D A, AU - Kim,M H, AU - Leon,M, PY - 1988/1/1/pubmed PY - 1988/1/1/medline PY - 1988/1/1/entrez SP - 85 EP - 90 JF - Physiology & behavior JO - Physiol Behav VL - 44 IS - 1 N2 - Following olfactory classical conditioning, infant rats exhibit a preference for the conditioned odor and exhibit enhanced uptake of focal 14C 2-deoxyglucose (2-DG) within the olfactory bulb. The present experiments assessed the role of respiration on the expression of the enhanced 2-DG uptake response. Pups were conditioned from postnatal day (PN) 1-18 with an olfactory stimulus paired with a reinforcing tactile stimulus which mimics maternal contact (Odor-Stroke). Control pups received odor only or tactile stimulation only. On PN 19, pups received 1 of 3 tests: 1) a two-odor choice test, 2) an odor/2-DG test with normal respiration allowed, or 3) an odor/2-DG test with respiration experimentally controlled. The results indicated that: 1) Odor-Stroke pups learned the conditioned odor preference, 2) Odor-Stroke, normally respiring pups exhibited enhanced olfactory bulb 2-DG uptake when compared to control pups. No difference in respiration rate was detected between groups in normally respiring pups. 3) Odor Stroke pups whose breathing was experimentally controlled exhibited enhanced olfactory bulb 2-DG uptake when compared to control pups with an identical number of respirations. Together, these results demonstrate that modified respiration during testing is not required for the expression of a modified olfactory bulb response to learned attractive odors. Therefore, the data suggest that the olfactory system itself is modified by early learning. SN - 0031-9384 UR - https://www.unboundmedicine.com/medline/citation/3237818/Behavioral_and_neural_correlates_of_postnatal_olfactory_conditioning:_I__Effect_of_respiration_on_conditioned_neural_responses_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0031-9384(88)90349-6 DB - PRIME DP - Unbound Medicine ER -