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[The Effect of Patient Age on Anticholinergic Use in the Elderly Japanese Population -Differences between Four Anticholinergic Scales].
Yakugaku Zasshi. 2020; 140(5):701-710.YZ

Abstract

We previously reported that anticholinergic (AC) drug use increases with age in the elderly Japanese population. In this analysis, we investigated attribution for each AC drug type to total AC burden using different elderly age groups. Prescription records (from 09/23/2015 to 12/31/2016) for outpatients using any AC were extracted from pharmacy claims (primary source) and hospital-based databases. AC burden (number of AC drugs and AC score) and AC type were assessed using the Anticholinergic Cognitive Burden (ACB) scale, Anticholinergic Drug Scale (ADS), Anticholinergic Risk Scale (ARS), and Beers criteria. Age was categorized using three subgroups (65-74, 75-84, and ≥85 years). Overall, 125426, 140634, 35628, and 23149 of the pharmacy outpatients received ≥1 AC drug from the ACB scale, ADS, ARS, or Beers criteria, respectively. The number of AC drugs increased with age for the ACB scale and ADS groups; but decreased for the ARS and Beers criteria. Antihypertensives provided the biggest contribution to AC score using the ACB scale and ADS, and antihistamines for the ARS. Proportional attribution to AC score typically increased with age for antihypertensives (ADS highest proportion: 34.6% for ≥85 years) and cardiac agents, but decreased for antihistamines (ARS lowest proportion: 15.3% for ≥85 years), corticosteroids, and antiepileptics. Similar findings were typically observed for the hospital database. In conclusion, antihypertensives were the principal type of AC drugs using the ACB scale and ADS and their attribution to AC score increased with age. Antihistamines were the principal drug type for the ARS.

Authors+Show Affiliations

Advanced Informatics and Analytics, Astellas Pharma Inc.Medical Affairs, Astellas Pharma Inc.Advanced Informatics and Analytics, Astellas Pharma Inc.Advanced Informatics and Analytics, Astellas US, LLC.Data Science, Astellas Pharma Inc.Department of Urology, National Center for Geriatrics and Gerontology.

Pub Type(s)

Journal Article

Language

jpn

PubMed ID

32378674

Citation

Kimura, Tomomi, et al. "[The Effect of Patient Age On Anticholinergic Use in the Elderly Japanese Population -Differences Between Four Anticholinergic Scales]." Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan, vol. 140, no. 5, 2020, pp. 701-710.
Kimura T, Kato D, Nishimura T, et al. [The Effect of Patient Age on Anticholinergic Use in the Elderly Japanese Population -Differences between Four Anticholinergic Scales]. Yakugaku Zasshi. 2020;140(5):701-710.
Kimura, T., Kato, D., Nishimura, T., Van Schyndle, J., Uno, S., & Yoshida, M. (2020). [The Effect of Patient Age on Anticholinergic Use in the Elderly Japanese Population -Differences between Four Anticholinergic Scales]. Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan, 140(5), 701-710. https://doi.org/10.1248/yakushi.19-00229
Kimura T, et al. [The Effect of Patient Age On Anticholinergic Use in the Elderly Japanese Population -Differences Between Four Anticholinergic Scales]. Yakugaku Zasshi. 2020;140(5):701-710. PubMed PMID: 32378674.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The Effect of Patient Age on Anticholinergic Use in the Elderly Japanese Population -Differences between Four Anticholinergic Scales]. AU - Kimura,Tomomi, AU - Kato,Daisuke, AU - Nishimura,Takuya, AU - Van Schyndle,James, AU - Uno,Satoshi, AU - Yoshida,Masaki, PY - 2020/5/8/entrez PY - 2020/5/8/pubmed PY - 2020/9/12/medline KW - Japan KW - anticholinergics KW - elderly SP - 701 EP - 710 JF - Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan JO - Yakugaku Zasshi VL - 140 IS - 5 N2 - We previously reported that anticholinergic (AC) drug use increases with age in the elderly Japanese population. In this analysis, we investigated attribution for each AC drug type to total AC burden using different elderly age groups. Prescription records (from 09/23/2015 to 12/31/2016) for outpatients using any AC were extracted from pharmacy claims (primary source) and hospital-based databases. AC burden (number of AC drugs and AC score) and AC type were assessed using the Anticholinergic Cognitive Burden (ACB) scale, Anticholinergic Drug Scale (ADS), Anticholinergic Risk Scale (ARS), and Beers criteria. Age was categorized using three subgroups (65-74, 75-84, and ≥85 years). Overall, 125426, 140634, 35628, and 23149 of the pharmacy outpatients received ≥1 AC drug from the ACB scale, ADS, ARS, or Beers criteria, respectively. The number of AC drugs increased with age for the ACB scale and ADS groups; but decreased for the ARS and Beers criteria. Antihypertensives provided the biggest contribution to AC score using the ACB scale and ADS, and antihistamines for the ARS. Proportional attribution to AC score typically increased with age for antihypertensives (ADS highest proportion: 34.6% for ≥85 years) and cardiac agents, but decreased for antihistamines (ARS lowest proportion: 15.3% for ≥85 years), corticosteroids, and antiepileptics. Similar findings were typically observed for the hospital database. In conclusion, antihypertensives were the principal type of AC drugs using the ACB scale and ADS and their attribution to AC score increased with age. Antihistamines were the principal drug type for the ARS. SN - 1347-5231 UR - https://www.unboundmedicine.com/medline/citation/32378674/[The_Effect_of_Patient_Age_on_Anticholinergic_Use_in_the_Elderly_Japanese_Population__Differences_between_Four_Anticholinergic_Scales]_ L2 - https://dx.doi.org/10.1248/yakushi.19-00229 DB - PRIME DP - Unbound Medicine ER -