Citation
Bilinska, Katarzyna, et al. "Expression of the SARS-CoV-2 Entry Proteins, ACE2 and TMPRSS2, in Cells of the Olfactory Epithelium: Identification of Cell Types and Trends With Age." ACS Chemical Neuroscience, vol. 11, no. 11, 2020, pp. 1555-1562.
Bilinska K, Jakubowska P, Von Bartheld CS, et al. Expression of the SARS-CoV-2 Entry Proteins, ACE2 and TMPRSS2, in Cells of the Olfactory Epithelium: Identification of Cell Types and Trends with Age. ACS Chem Neurosci. 2020;11(11):1555-1562.
Bilinska, K., Jakubowska, P., Von Bartheld, C. S., & Butowt, R. (2020). Expression of the SARS-CoV-2 Entry Proteins, ACE2 and TMPRSS2, in Cells of the Olfactory Epithelium: Identification of Cell Types and Trends with Age. ACS Chemical Neuroscience, 11(11), 1555-1562. https://doi.org/10.1021/acschemneuro.0c00210
Bilinska K, et al. Expression of the SARS-CoV-2 Entry Proteins, ACE2 and TMPRSS2, in Cells of the Olfactory Epithelium: Identification of Cell Types and Trends With Age. ACS Chem Neurosci. 2020 06 3;11(11):1555-1562. PubMed PMID: 32379417.
TY - JOUR
T1 - Expression of the SARS-CoV-2 Entry Proteins, ACE2 and TMPRSS2, in Cells of the Olfactory Epithelium: Identification of Cell Types and Trends with Age.
AU - Bilinska,Katarzyna,
AU - Jakubowska,Patrycja,
AU - Von Bartheld,Christopher S,
AU - Butowt,Rafal,
Y1 - 2020/05/19/
PY - 2020/5/8/pubmed
PY - 2020/6/12/medline
PY - 2020/5/8/entrez
KW - ACE2 expression
KW - COVID-19
KW - SARS-CoV-2
KW - aging
KW - anosmia
KW - olfactory epithelium
SP - 1555
EP - 1562
JF - ACS chemical neuroscience
JO - ACS Chem Neurosci
VL - 11
IS - 11
N2 - The COVID-19 pandemic revealed that there is a loss of smell in many patients, including in infected but otherwise asymptomatic individuals. The underlying mechanisms for the olfactory symptoms are unclear. Using a mouse model, we determined whether cells in the olfactory epithelium express the obligatory receptors for entry of the SARS-CoV-2 virus by using RNAseq, RT-PCR, in situ hybridization, Western blot, and immunocytochemistry. We show that the cell surface protein ACE2 and the protease TMPRSS2 are expressed in sustentacular cells of the olfactory epithelium but not, or much less, in most olfactory receptor neurons. These data suggest that sustentacular cells are involved in SARS-CoV-2 virus entry and impairment of the sense of smell in COVID-19 patients. We also show that expression of the entry proteins increases in animals of old age. This may explain, if true also in humans, why individuals of older age are more susceptible to the SARS-CoV-2 infection.
SN - 1948-7193
UR - https://www.unboundmedicine.com/medline/citation/32379417/full_citation
L2 - https://doi.org/10.1021/acschemneuro.0c00210
DB - PRIME
DP - Unbound Medicine
ER -