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Nick Martin and the Genetics of Depression: Sample Size, Sample Size, Sample Size.
Twin Res Hum Genet. 2020 Apr; 23(2):109-111.TR

Abstract

Nick Martin is a pioneer in recognizing the need for large sample size to study the complex, heterogeneous and polygenic disorders of common mental disorders. In the predigital era, questionnaires were mailed to thousands of twin pairs around Australia. Always quick to adopt new technology, Nick's studies progressed to phone interviews and then online. Moreover, Nick was early to recognize the value of collecting DNA samples. As genotyping technologies improved over the years, these twin and family cohorts were used for linkage, candidate gene and genome-wide association studies. These cohorts have underpinned many analyses to disentangle the complex web of genetic and lifestyle factors associated with mental health. With characteristic foresight, Nick is chief investigator of our Australian Genetics of Depression Study, which has recruited 16,000 people with self-reported depression (plus DNA samples) over a time frame of a few months - analyses are currently ongoing. The mantra of sample size, sample size, sample size has guided Nick's research over the last 30 years and continues to do so.

Authors+Show Affiliations

Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia.Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia.Brain and Mind Centre, Faculty of Medicine and Health, University of Sydney Central Clinical School, Sydney, Australia.Child Health Research Centre, University of Queensland, Brisbane, Australia. Child and Youth Mental Health Service, Children's Health Queensland Hospital and Health Service, Brisbane, Australia. Vrije Universiteit, Amsterdam, The Netherlands.Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia. Queensland Brain Institute, University of Queensland, Brisbane, Australia.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32383421

Citation

Byrne, Enda M., et al. "Nick Martin and the Genetics of Depression: Sample Size, Sample Size, Sample Size." Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies, vol. 23, no. 2, 2020, pp. 109-111.
Byrne EM, Henders AK, Hickie IB, et al. Nick Martin and the Genetics of Depression: Sample Size, Sample Size, Sample Size. Twin Res Hum Genet. 2020;23(2):109-111.
Byrne, E. M., Henders, A. K., Hickie, I. B., Middeldorp, C. M., & Wray, N. R. (2020). Nick Martin and the Genetics of Depression: Sample Size, Sample Size, Sample Size. Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies, 23(2), 109-111. https://doi.org/10.1017/thg.2020.13
Byrne EM, et al. Nick Martin and the Genetics of Depression: Sample Size, Sample Size, Sample Size. Twin Res Hum Genet. 2020;23(2):109-111. PubMed PMID: 32383421.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nick Martin and the Genetics of Depression: Sample Size, Sample Size, Sample Size. AU - Byrne,Enda M, AU - Henders,Anjali K, AU - Hickie,Ian B, AU - Middeldorp,Christel M, AU - Wray,Naomi R, Y1 - 2020/05/08/ PY - 2020/5/10/pubmed PY - 2020/5/10/medline PY - 2020/5/9/entrez KW - Major depressive disorder KW - genome-wide association study KW - twin study SP - 109 EP - 111 JF - Twin research and human genetics : the official journal of the International Society for Twin Studies JO - Twin Res Hum Genet VL - 23 IS - 2 N2 - Nick Martin is a pioneer in recognizing the need for large sample size to study the complex, heterogeneous and polygenic disorders of common mental disorders. In the predigital era, questionnaires were mailed to thousands of twin pairs around Australia. Always quick to adopt new technology, Nick's studies progressed to phone interviews and then online. Moreover, Nick was early to recognize the value of collecting DNA samples. As genotyping technologies improved over the years, these twin and family cohorts were used for linkage, candidate gene and genome-wide association studies. These cohorts have underpinned many analyses to disentangle the complex web of genetic and lifestyle factors associated with mental health. With characteristic foresight, Nick is chief investigator of our Australian Genetics of Depression Study, which has recruited 16,000 people with self-reported depression (plus DNA samples) over a time frame of a few months - analyses are currently ongoing. The mantra of sample size, sample size, sample size has guided Nick's research over the last 30 years and continues to do so. SN - 1832-4274 UR - https://www.unboundmedicine.com/medline/citation/32383421/Nick_Martin_and_the_Genetics_of_Depression:_Sample_Size,_Sample_Size,_Sample_Size L2 - https://www.cambridge.org/core/product/identifier/S1832427420000134/type/journal_article DB - PRIME DP - Unbound Medicine ER -
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