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Severe Acute Respiratory Syndrome Coronavirus 2 Pandemic.
Arch Pathol Lab Med. 2020 09 01; 144(9):1048-1056.AP

Abstract

CONTEXT.—

The novel coronavirus disease 2019 (COVID-19) pandemic is significantly changing methodologic approaches in all branches of the health system. From a forensic point of view, this event is partly changing the manner in which forensic pathologists and all those who work in autopsy services operate, but above all, it is changing the patterns established for years by which cadavers are analyzed postmortem.

OBJECTIVE.—

To present a review of the literature and a proposal for COVID-19 autopsy protocols. To contain the infection risk, a revision of all the protocols that until now have been applied to the examination of bodies that require autopsy services is required.

DATA SOURCES.—

Currently, the diagnosis and postmortem analysis of positive or suspected COVID-19 cases plays a crucial role in scientific research. A review of the main recommendations proposed by international scientific societies regarding the risk of infection during autopsy was carried out. Scientific papers currently available via the PubMed NCBI search engine on COVID-19 postmortem diagnosis were also examined.

CONCLUSIONS.—

Throughout the history of medicine, autopsy has been fundamental to the understanding of multiple pathogenic processes that are investigated postmortem. The purpose of the study is to propose an operating protocol that can be useful for all clinical and forensic autopsies, with particular reference to the correct methods to be applied to the examination of positive or suspected COVID-19 cases, regarding both the autopsy procedure and the collection and analysis of biological samples.

Authors+Show Affiliations

From the Institute of Legal Medicine and Department of Surgical and Medical Sciences (Aquila, Sacco, C. Ricci, Gratteri, P. Ricci).From the Institute of Legal Medicine and Department of Surgical and Medical Sciences (Aquila, Sacco, C. Ricci, Gratteri, P. Ricci).Department of Health Sciences (Abenavoli), University "Magna Graecia," Catanzaro, Italy.Department of Clinical and Experimental Medicine (Malara), University "Magna Graecia," Catanzaro, Italy.Area of Pathology, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Istituto di Anatomia Patologica (Arena).Department of Health Surveillance and Bioethics, Section of Legal Medicine, Fondazione Policlinico A. Gemelli IRCCS (Grassi, Ausania, Oliva), Università Cattolica del Sacro Cuore, Rome, Italy.Department of Health Surveillance and Bioethics, Section of Legal Medicine, Fondazione Policlinico A. Gemelli IRCCS (Grassi, Ausania, Oliva), Università Cattolica del Sacro Cuore, Rome, Italy.JC Self Research Institute, Greenwood Genetic Center, Greenwood, South Carolina (Boccuto). School of Health Research, Clemson University, Clemson, South Carolina (Boccuto).From the Institute of Legal Medicine and Department of Surgical and Medical Sciences (Aquila, Sacco, C. Ricci, Gratteri, P. Ricci).From the Institute of Legal Medicine and Department of Surgical and Medical Sciences (Aquila, Sacco, C. Ricci, Gratteri, P. Ricci).Department of Health Surveillance and Bioethics, Section of Legal Medicine, Fondazione Policlinico A. Gemelli IRCCS (Grassi, Ausania, Oliva), Università Cattolica del Sacro Cuore, Rome, Italy.From the Institute of Legal Medicine and Department of Surgical and Medical Sciences (Aquila, Sacco, C. Ricci, Gratteri, P. Ricci).

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32383963

Citation

Aquila, Isabella, et al. "Severe Acute Respiratory Syndrome Coronavirus 2 Pandemic." Archives of Pathology & Laboratory Medicine, vol. 144, no. 9, 2020, pp. 1048-1056.
Aquila I, Sacco MA, Abenavoli L, et al. Severe Acute Respiratory Syndrome Coronavirus 2 Pandemic. Arch Pathol Lab Med. 2020;144(9):1048-1056.
Aquila, I., Sacco, M. A., Abenavoli, L., Malara, N., Arena, V., Grassi, S., Ausania, F., Boccuto, L., Ricci, C., Gratteri, S., Oliva, A., & Ricci, P. (2020). Severe Acute Respiratory Syndrome Coronavirus 2 Pandemic. Archives of Pathology & Laboratory Medicine, 144(9), 1048-1056. https://doi.org/10.5858/arpa.2020-0165-SA
Aquila I, et al. Severe Acute Respiratory Syndrome Coronavirus 2 Pandemic. Arch Pathol Lab Med. 2020 09 1;144(9):1048-1056. PubMed PMID: 32383963.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Severe Acute Respiratory Syndrome Coronavirus 2 Pandemic. AU - Aquila,Isabella, AU - Sacco,Matteo Antonio, AU - Abenavoli,Ludovico, AU - Malara,Natalia, AU - Arena,Vincenzo, AU - Grassi,Simone, AU - Ausania,Francesco, AU - Boccuto,Luigi, AU - Ricci,Cristoforo, AU - Gratteri,Santo, AU - Oliva,Antonio, AU - Ricci,Pietrantonio, PY - 2020/05/05/accepted PY - 2020/5/10/pubmed PY - 2020/9/17/medline PY - 2020/5/9/entrez SP - 1048 EP - 1056 JF - Archives of pathology & laboratory medicine JO - Arch Pathol Lab Med VL - 144 IS - 9 N2 - CONTEXT.—: The novel coronavirus disease 2019 (COVID-19) pandemic is significantly changing methodologic approaches in all branches of the health system. From a forensic point of view, this event is partly changing the manner in which forensic pathologists and all those who work in autopsy services operate, but above all, it is changing the patterns established for years by which cadavers are analyzed postmortem. OBJECTIVE.—: To present a review of the literature and a proposal for COVID-19 autopsy protocols. To contain the infection risk, a revision of all the protocols that until now have been applied to the examination of bodies that require autopsy services is required. DATA SOURCES.—: Currently, the diagnosis and postmortem analysis of positive or suspected COVID-19 cases plays a crucial role in scientific research. A review of the main recommendations proposed by international scientific societies regarding the risk of infection during autopsy was carried out. Scientific papers currently available via the PubMed NCBI search engine on COVID-19 postmortem diagnosis were also examined. CONCLUSIONS.—: Throughout the history of medicine, autopsy has been fundamental to the understanding of multiple pathogenic processes that are investigated postmortem. The purpose of the study is to propose an operating protocol that can be useful for all clinical and forensic autopsies, with particular reference to the correct methods to be applied to the examination of positive or suspected COVID-19 cases, regarding both the autopsy procedure and the collection and analysis of biological samples. SN - 1543-2165 UR - https://www.unboundmedicine.com/medline/citation/32383963/Severe_Acute_Respiratory_Syndrome_Coronavirus_2_Pandemic_ L2 - https://meridian.allenpress.com/aplm/article-lookup/doi/10.5858/arpa.2020-0165-SA DB - PRIME DP - Unbound Medicine ER -