Tags

Type your tag names separated by a space and hit enter

Hemodynamic Change of Coronary Atherosclerotic Plaque After Statin Treatment: A Serial Follow-Up Study by Computed Tomography-Derived Fractional Flow Reserve.
J Am Heart Assoc. 2020 05 18; 9(10):e015772.JA

Abstract

Background Whether statin treatment can improve hemodynamic status of coronary atherosclerotic plaque remains unknown. It is of clinical interest to explore the hemodynamic change of coronary lesions after statin treatment. Methods and Results Consecutive patients with intermediate pre-test probability of coronary artery disease were prospectively enrolled and underwent baseline coronary computed tomography angiography (CCTA) as well as follow-up CCTA. The primary end point was to determine the lesion-specific change of △computed tomography-derived fractional flow reserve (△CT-FFR, defined as the change of CT-FFR value across each lesion) after rosuvastatin treatment. The secondary end point was to compare the change of other plaque characteristics according to serial CCTA findings. 152 patients (mean age: 67.1±9.7 years, 100 men, mean follow-up duration of 13.9±2.5 months) were finally included. In non-calcified plaque subgroup, △CT-FFR was significantly lower at follow-up compared with baseline (0.051±0.010 versus 0.035±0.012, P=0.013). All other parameters were not found to be significantly different between baseline and follow-up CCTA measurements. In calcified plaque and mixed plaque subgroups, all parameters showed no significant differences between baseline and follow-up CCTA groups (P>0.05 for all). According to multivariate regression analysis, non-calcified plaque was >2 times more likely than calcified plaque to observe the decrease of △CT-FFR (adjusted hazard ratio: 2.05 [1.03-4.09], P=0.042). Conclusions In patients with mild to intermediate coronary stenosis, rosuvastatin treatment resulted in a reduction in lesion-specific △CT-FFR at mid-term follow-up. This hemodynamic improvement was mainly observed for non-calcified lesions.

Authors+Show Affiliations

Institute of Diagnostic and Interventional Radiology Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai China.Institute of Diagnostic and Interventional Radiology Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai China.Institute of Diagnostic and Interventional Radiology Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai China.Department of Cardiology Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai China.Department of Cardiology Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai China.Department of Radiology Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai China.Institute of Diagnostic and Interventional Radiology Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

32384006

Citation

Yu, Mengmeng, et al. "Hemodynamic Change of Coronary Atherosclerotic Plaque After Statin Treatment: a Serial Follow-Up Study By Computed Tomography-Derived Fractional Flow Reserve." Journal of the American Heart Association, vol. 9, no. 10, 2020, pp. e015772.
Yu M, Dai X, Yu L, et al. Hemodynamic Change of Coronary Atherosclerotic Plaque After Statin Treatment: A Serial Follow-Up Study by Computed Tomography-Derived Fractional Flow Reserve. J Am Heart Assoc. 2020;9(10):e015772.
Yu, M., Dai, X., Yu, L., Lu, Z., Shen, C., Tao, X., & Zhang, J. (2020). Hemodynamic Change of Coronary Atherosclerotic Plaque After Statin Treatment: A Serial Follow-Up Study by Computed Tomography-Derived Fractional Flow Reserve. Journal of the American Heart Association, 9(10), e015772. https://doi.org/10.1161/JAHA.120.015772
Yu M, et al. Hemodynamic Change of Coronary Atherosclerotic Plaque After Statin Treatment: a Serial Follow-Up Study By Computed Tomography-Derived Fractional Flow Reserve. J Am Heart Assoc. 2020 05 18;9(10):e015772. PubMed PMID: 32384006.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hemodynamic Change of Coronary Atherosclerotic Plaque After Statin Treatment: A Serial Follow-Up Study by Computed Tomography-Derived Fractional Flow Reserve. AU - Yu,Mengmeng, AU - Dai,Xu, AU - Yu,Lihua, AU - Lu,Zhigang, AU - Shen,Chengxing, AU - Tao,Xiaofeng, AU - Zhang,Jiayin, Y1 - 2020/05/08/ PY - 2020/5/10/pubmed PY - 2021/3/10/medline PY - 2020/5/9/entrez KW - coronary CT angiography KW - coronary artery disease KW - fractional flow reserve KW - plaque KW - statin SP - e015772 EP - e015772 JF - Journal of the American Heart Association JO - J Am Heart Assoc VL - 9 IS - 10 N2 - Background Whether statin treatment can improve hemodynamic status of coronary atherosclerotic plaque remains unknown. It is of clinical interest to explore the hemodynamic change of coronary lesions after statin treatment. Methods and Results Consecutive patients with intermediate pre-test probability of coronary artery disease were prospectively enrolled and underwent baseline coronary computed tomography angiography (CCTA) as well as follow-up CCTA. The primary end point was to determine the lesion-specific change of △computed tomography-derived fractional flow reserve (△CT-FFR, defined as the change of CT-FFR value across each lesion) after rosuvastatin treatment. The secondary end point was to compare the change of other plaque characteristics according to serial CCTA findings. 152 patients (mean age: 67.1±9.7 years, 100 men, mean follow-up duration of 13.9±2.5 months) were finally included. In non-calcified plaque subgroup, △CT-FFR was significantly lower at follow-up compared with baseline (0.051±0.010 versus 0.035±0.012, P=0.013). All other parameters were not found to be significantly different between baseline and follow-up CCTA measurements. In calcified plaque and mixed plaque subgroups, all parameters showed no significant differences between baseline and follow-up CCTA groups (P>0.05 for all). According to multivariate regression analysis, non-calcified plaque was >2 times more likely than calcified plaque to observe the decrease of △CT-FFR (adjusted hazard ratio: 2.05 [1.03-4.09], P=0.042). Conclusions In patients with mild to intermediate coronary stenosis, rosuvastatin treatment resulted in a reduction in lesion-specific △CT-FFR at mid-term follow-up. This hemodynamic improvement was mainly observed for non-calcified lesions. SN - 2047-9980 UR - https://www.unboundmedicine.com/medline/citation/32384006/Hemodynamic_Change_of_Coronary_Atherosclerotic_Plaque_After_Statin_Treatment:_A_Serial_Follow_Up_Study_by_Computed_Tomography_Derived_Fractional_Flow_Reserve_ L2 - https://www.ahajournals.org/doi/10.1161/JAHA.120.015772?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -