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Effects of fish oil supplementation on glucose control and lipid levels among patients with type 2 diabetes mellitus: a Meta-analysis of randomized controlled trials.
Lipids Health Dis. 2020 May 08; 19(1):87.LH

Abstract

BACKGROUND

Previous studies have yielded inconsistent findings on the role of fish oil in type 2 diabetes mellitus (T2DM). We systematically summarized the available evidence from randomized controlled trials (RCT) and aimed to investigate the effects of fish oil supplementation on glucose control and lipid levels among patients with T2DM.

METHODS

A comprehensive literature search was performed in electronic databases (PubMed, ProQuest, Cochrane Library, CNKI, VIP, and Wanfang) to identify all relevant RCTs which were published up to May 31st, 2019. We used Modified Jadad Score system to evaluate the quality of each included RCT. The pooled effects were estimated using random-effects model and presented as standardized mean differences with 95% confidence intervals.

RESULTS

A total of 12 RCTs were included in this meta-analysis. There was no significant difference in glucose control outcomes comparing fish oil supplementation to placebo. The effect size of fasting plasma glucose (FPG) was 0.13 (95% CI: - 0.03 to 0.28, p > 0.05). No marked change was observed in fasting insulin (FINS), glycosylated hemoglobin (HbA1c), and HOMA of insulin resistance (HOMA-IR) levels. Fish oil supplementation was associated with a decrease of triglyceride (TG) level by - 0.40 (95%CI: - 0.53 to - 0.28, p < 0.05), and an increase of high density lipoprotein (HDL) cholesterol level by 0.21 (95%CI: 0.05 to 0.37, p < 0.05). In subgroup analysis, HDL cholesterol level was higher among Asian and low-dose(< 2 g/d n-3 PUFA) subgroups compared to their counterparts (p < 0.05). TG level was lower in mid and long duration groups, along with an inconspicuous difference in short duration group.

CONCLUSIONS

This meta-analysis shows that among patients with T2DM, fish oil supplementation leads to a favorable blood lipids profile but does not improve glucose control.

Authors+Show Affiliations

Key Laboratory of Trace Element Nutrition of National Health Commission, National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, No 29 Nanwei Road, Beijing, 100050, China.Key Laboratory of Trace Element Nutrition of National Health Commission, National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, No 29 Nanwei Road, Beijing, 100050, China.School of Public Health, Tongji Medical College, Ministry of Education Key Laboratory of Environment, Hubei Key Laboratory of Food Nutrition and Safety, Huazhong University of Science and Technology, Wuhan, 430030, China.Department of Epidemiology, College of Public Health, Fraternal Order of Eagles Diabetes Research Center, University of Iowa, Iowa, 52242, USA.Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, 518000, China.Key Laboratory of Trace Element Nutrition of National Health Commission, National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, No 29 Nanwei Road, Beijing, 100050, China.Key Laboratory of Trace Element Nutrition of National Health Commission, National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, No 29 Nanwei Road, Beijing, 100050, China.Key Laboratory of Trace Element Nutrition of National Health Commission, National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, No 29 Nanwei Road, Beijing, 100050, China.School of Public Health, Tongji Medical College, Ministry of Education Key Laboratory of Environment, Hubei Key Laboratory of Food Nutrition and Safety, Huazhong University of Science and Technology, Wuhan, 430030, China.Key Laboratory of Trace Element Nutrition of National Health Commission, National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, No 29 Nanwei Road, Beijing, 100050, China.Key Laboratory of Trace Element Nutrition of National Health Commission, National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, No 29 Nanwei Road, Beijing, 100050, China. yxyang@263.net.

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

32384902

Citation

Gao, Chao, et al. "Effects of Fish Oil Supplementation On Glucose Control and Lipid Levels Among Patients With Type 2 Diabetes Mellitus: a Meta-analysis of Randomized Controlled Trials." Lipids in Health and Disease, vol. 19, no. 1, 2020, p. 87.
Gao C, Liu Y, Gan Y, et al. Effects of fish oil supplementation on glucose control and lipid levels among patients with type 2 diabetes mellitus: a Meta-analysis of randomized controlled trials. Lipids Health Dis. 2020;19(1):87.
Gao, C., Liu, Y., Gan, Y., Bao, W., Peng, X., Xing, Q., Gao, H., Lai, J., Liu, L., Wang, Z., & Yang, Y. (2020). Effects of fish oil supplementation on glucose control and lipid levels among patients with type 2 diabetes mellitus: a Meta-analysis of randomized controlled trials. Lipids in Health and Disease, 19(1), 87. https://doi.org/10.1186/s12944-020-01214-w
Gao C, et al. Effects of Fish Oil Supplementation On Glucose Control and Lipid Levels Among Patients With Type 2 Diabetes Mellitus: a Meta-analysis of Randomized Controlled Trials. Lipids Health Dis. 2020 May 8;19(1):87. PubMed PMID: 32384902.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of fish oil supplementation on glucose control and lipid levels among patients with type 2 diabetes mellitus: a Meta-analysis of randomized controlled trials. AU - Gao,Chao, AU - Liu,Yang, AU - Gan,Yong, AU - Bao,Wei, AU - Peng,Xiaolin, AU - Xing,Qingbin, AU - Gao,Huiyu, AU - Lai,Jianqiang, AU - Liu,Liegang, AU - Wang,Zhu, AU - Yang,Yuexin, Y1 - 2020/05/08/ PY - 2019/11/12/received PY - 2020/02/24/accepted PY - 2020/5/10/entrez PY - 2020/5/10/pubmed PY - 2021/3/13/medline KW - Fish oil KW - Meta-analysis KW - Omega-3 fatty acids KW - Randomized clinical trials KW - Type 2 diabetes mellitus SP - 87 EP - 87 JF - Lipids in health and disease JO - Lipids Health Dis VL - 19 IS - 1 N2 - BACKGROUND: Previous studies have yielded inconsistent findings on the role of fish oil in type 2 diabetes mellitus (T2DM). We systematically summarized the available evidence from randomized controlled trials (RCT) and aimed to investigate the effects of fish oil supplementation on glucose control and lipid levels among patients with T2DM. METHODS: A comprehensive literature search was performed in electronic databases (PubMed, ProQuest, Cochrane Library, CNKI, VIP, and Wanfang) to identify all relevant RCTs which were published up to May 31st, 2019. We used Modified Jadad Score system to evaluate the quality of each included RCT. The pooled effects were estimated using random-effects model and presented as standardized mean differences with 95% confidence intervals. RESULTS: A total of 12 RCTs were included in this meta-analysis. There was no significant difference in glucose control outcomes comparing fish oil supplementation to placebo. The effect size of fasting plasma glucose (FPG) was 0.13 (95% CI: - 0.03 to 0.28, p > 0.05). No marked change was observed in fasting insulin (FINS), glycosylated hemoglobin (HbA1c), and HOMA of insulin resistance (HOMA-IR) levels. Fish oil supplementation was associated with a decrease of triglyceride (TG) level by - 0.40 (95%CI: - 0.53 to - 0.28, p < 0.05), and an increase of high density lipoprotein (HDL) cholesterol level by 0.21 (95%CI: 0.05 to 0.37, p < 0.05). In subgroup analysis, HDL cholesterol level was higher among Asian and low-dose(< 2 g/d n-3 PUFA) subgroups compared to their counterparts (p < 0.05). TG level was lower in mid and long duration groups, along with an inconspicuous difference in short duration group. CONCLUSIONS: This meta-analysis shows that among patients with T2DM, fish oil supplementation leads to a favorable blood lipids profile but does not improve glucose control. SN - 1476-511X UR - https://www.unboundmedicine.com/medline/citation/32384902/Effects_of_fish_oil_supplementation_on_glucose_control_and_lipid_levels_among_patients_with_type_2_diabetes_mellitus:_a_Meta_analysis_of_randomized_controlled_trials_ L2 - https://lipidworld.biomedcentral.com/articles/10.1186/s12944-020-01214-w DB - PRIME DP - Unbound Medicine ER -