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Are polyploid giant cancer cells in high grade serous carcinoma of the ovary blastomere-like cancer stem cells?
Ann Diagn Pathol. 2020 Mar 18; 46:151505.AD

Abstract

Polyploid giant cancer cells, either multinucleated or mononucleated, in high grade serous carcinoma of the ovary have been previously recognized. Different theories including degenerative changes or an important step in the development of high grade serous carcinoma have been proposed. Here we investigate possible explanations for the presence of polyploid giant cancer cells in high grade serous carcinoma. We reviewed 33 cases of ovarian high grade serous carcinoma (12 stage I, 7 stage II, and 14 stage III). We counted the number of polyploid giant cancer cells in 20 consecutive 10× fields. In 11 cases where polyploid giant cancer cells were easily found, immunohistochemistry for Ki67, p53, and OCT 3/4 was performed. Patients with polyploid giant cancer cells were older than those without. Polyploid giant cancer cells were more frequent in stage I lesions (75%) than in stages II or III (57% in both) and less frequent in metastases compared with primary ovarian tumors. Mitotic figures were present in regular sized cells but were absent in polyploid giant cancer cells. OCT3/4 was negative in all cases assessed. In 8 cases, more than 70% of the mononuclear cells were positive for Ki-67, similar to the percentage of Ki-67 positive cells in polyploid giant cancer cells. p53 had a perfect correlation in regular sized cancer cells and in polyploid giant cancer cells. Polyploid giant cancer cells are neither degenerative cells nor traditional cancer stem cells but most probably represent an intermediate step between stem cells and mature tumor cells formed by endoreplication.

Authors+Show Affiliations

Baylor University Medical Center, Department of Pathology, 3600 Gaston Avenue, Dallas, TX 75246, United States of America.Baylor University Medical Center, Department of Pathology, 3600 Gaston Avenue, Dallas, TX 75246, United States of America.Baylor University Medical Center, Department of Pathology, 3600 Gaston Avenue, Dallas, TX 75246, United States of America.University of Texas MD Anderson Cancer Center, Department of Pathology, 1515 Holcombe Blvd. Unit 0072, Houston, TX 77030, United States of America.Baylor University Medical Center, Department of Pathology, 3600 Gaston Avenue, Dallas, TX 75246, United States of America; University of Texas MD Anderson Cancer Center, Department of Pathology, 1515 Holcombe Blvd. Unit 0072, Houston, TX 77030, United States of America. Electronic address: elvio.silva@bswhealth.org.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32387856

Citation

Salem, Alireza, et al. "Are Polyploid Giant Cancer Cells in High Grade Serous Carcinoma of the Ovary Blastomere-like Cancer Stem Cells?" Annals of Diagnostic Pathology, vol. 46, 2020, p. 151505.
Salem A, Pinto K, Koch M, et al. Are polyploid giant cancer cells in high grade serous carcinoma of the ovary blastomere-like cancer stem cells? Ann Diagn Pathol. 2020;46:151505.
Salem, A., Pinto, K., Koch, M., Liu, J., & Silva, E. G. (2020). Are polyploid giant cancer cells in high grade serous carcinoma of the ovary blastomere-like cancer stem cells? Annals of Diagnostic Pathology, 46, 151505. https://doi.org/10.1016/j.anndiagpath.2020.151505
Salem A, et al. Are Polyploid Giant Cancer Cells in High Grade Serous Carcinoma of the Ovary Blastomere-like Cancer Stem Cells. Ann Diagn Pathol. 2020 Mar 18;46:151505. PubMed PMID: 32387856.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Are polyploid giant cancer cells in high grade serous carcinoma of the ovary blastomere-like cancer stem cells? AU - Salem,Alireza, AU - Pinto,Karen, AU - Koch,Meghan, AU - Liu,Jinsong, AU - Silva,Elvio G, Y1 - 2020/03/18/ PY - 2019/11/10/received PY - 2020/03/03/accepted PY - 2020/5/11/pubmed PY - 2020/5/11/medline PY - 2020/5/11/entrez KW - Blastomere-like cancer stem cells KW - Endoreplication KW - High grade serous carcinoma KW - Multinucleated and giant tumor cells KW - Ovary KW - Polyploid giant cancer cells SP - 151505 EP - 151505 JF - Annals of diagnostic pathology JO - Ann Diagn Pathol VL - 46 N2 - Polyploid giant cancer cells, either multinucleated or mononucleated, in high grade serous carcinoma of the ovary have been previously recognized. Different theories including degenerative changes or an important step in the development of high grade serous carcinoma have been proposed. Here we investigate possible explanations for the presence of polyploid giant cancer cells in high grade serous carcinoma. We reviewed 33 cases of ovarian high grade serous carcinoma (12 stage I, 7 stage II, and 14 stage III). We counted the number of polyploid giant cancer cells in 20 consecutive 10× fields. In 11 cases where polyploid giant cancer cells were easily found, immunohistochemistry for Ki67, p53, and OCT 3/4 was performed. Patients with polyploid giant cancer cells were older than those without. Polyploid giant cancer cells were more frequent in stage I lesions (75%) than in stages II or III (57% in both) and less frequent in metastases compared with primary ovarian tumors. Mitotic figures were present in regular sized cells but were absent in polyploid giant cancer cells. OCT3/4 was negative in all cases assessed. In 8 cases, more than 70% of the mononuclear cells were positive for Ki-67, similar to the percentage of Ki-67 positive cells in polyploid giant cancer cells. p53 had a perfect correlation in regular sized cancer cells and in polyploid giant cancer cells. Polyploid giant cancer cells are neither degenerative cells nor traditional cancer stem cells but most probably represent an intermediate step between stem cells and mature tumor cells formed by endoreplication. SN - 1532-8198 UR - https://www.unboundmedicine.com/medline/citation/32387856/Are_polyploid_giant_cancer_cells_in_high_grade_serous_carcinoma_of_the_ovary_blastomere-like_cancer_stem_cells L2 - https://linkinghub.elsevier.com/retrieve/pii/S1092-9134(20)30046-0 DB - PRIME DP - Unbound Medicine ER -
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