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Evaluation of pharmaceutical abuse and illicit drug use in South Korea by wastewater-based epidemiology.
J Hazard Mater. 2020 09 05; 396:122622.JH

Abstract

Drug abuse trends in South Korea were assessed by estimating the consumption rates of drugs that may be abused or misused by performing wastewater-based drug epidemiology. Of the 29 target compounds, 10 were found in samples from three wastewater treatment plants. Ephedrine had the highest mean estimated consumption rate, 574.1 mg d-1 (1000 people)-1. The anti-obesity drugs phendimetrazine and phentermine had the second and fifth highest mean estimated consumption rates, 182.9 and 113.1 mg d-1 (1000 people)-1, respectively. The zolpidem consumption rate was 65.8 mg d-1 (1000 people)-1. Methamphetamine was the only illicit drug detected in wastewater, and the estimated consumption rates (14.9-28.6 mg d-1 (1000 people)-1) were similar to consumption rates found in previous Korean studies (not detected to 45.8 mg d-1 (1000 people)-1). The mean estimated meperidine and cis-tramadol (opioid) consumption rates were 120 and 27.5 mg d-1 (1000 people)-1, respectively, and were 8.2 and 1.7 times higher, respectively, than the consumption rates found in 2013. Methylphenidate was detected in the influent and effluent samples at mean concentrations of 2.7 and 2.6 ng L-1, respectively, but the methylphenidate consumption rate could not be estimated because of the low excretion rate for humans (<1%).

Authors+Show Affiliations

Department of Civil and Environmental Engineering, Pusan National University, Jangjeon-dong, Geumjeong-gu, Busan 46241, Republic of Korea.Department of Civil and Environmental Engineering, Pusan National University, Jangjeon-dong, Geumjeong-gu, Busan 46241, Republic of Korea. Electronic address: jeoh@pusan.ac.kr.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

32388180

Citation

Kim, Ki Yong, and Jeong-Eun Oh. "Evaluation of Pharmaceutical Abuse and Illicit Drug Use in South Korea By Wastewater-based Epidemiology." Journal of Hazardous Materials, vol. 396, 2020, p. 122622.
Kim KY, Oh JE. Evaluation of pharmaceutical abuse and illicit drug use in South Korea by wastewater-based epidemiology. J Hazard Mater. 2020;396:122622.
Kim, K. Y., & Oh, J. E. (2020). Evaluation of pharmaceutical abuse and illicit drug use in South Korea by wastewater-based epidemiology. Journal of Hazardous Materials, 396, 122622. https://doi.org/10.1016/j.jhazmat.2020.122622
Kim KY, Oh JE. Evaluation of Pharmaceutical Abuse and Illicit Drug Use in South Korea By Wastewater-based Epidemiology. J Hazard Mater. 2020 09 5;396:122622. PubMed PMID: 32388180.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of pharmaceutical abuse and illicit drug use in South Korea by wastewater-based epidemiology. AU - Kim,Ki Yong, AU - Oh,Jeong-Eun, Y1 - 2020/04/07/ PY - 2020/01/08/received PY - 2020/03/20/revised PY - 2020/03/30/accepted PY - 2020/5/11/pubmed PY - 2020/5/11/medline PY - 2020/5/11/entrez KW - Consumption rate KW - Drug abuse KW - Illicit drugs KW - Psychoactive pharmaceuticals KW - Wastewater-based epidemiology SP - 122622 EP - 122622 JF - Journal of hazardous materials JO - J. Hazard. Mater. VL - 396 N2 - Drug abuse trends in South Korea were assessed by estimating the consumption rates of drugs that may be abused or misused by performing wastewater-based drug epidemiology. Of the 29 target compounds, 10 were found in samples from three wastewater treatment plants. Ephedrine had the highest mean estimated consumption rate, 574.1 mg d-1 (1000 people)-1. The anti-obesity drugs phendimetrazine and phentermine had the second and fifth highest mean estimated consumption rates, 182.9 and 113.1 mg d-1 (1000 people)-1, respectively. The zolpidem consumption rate was 65.8 mg d-1 (1000 people)-1. Methamphetamine was the only illicit drug detected in wastewater, and the estimated consumption rates (14.9-28.6 mg d-1 (1000 people)-1) were similar to consumption rates found in previous Korean studies (not detected to 45.8 mg d-1 (1000 people)-1). The mean estimated meperidine and cis-tramadol (opioid) consumption rates were 120 and 27.5 mg d-1 (1000 people)-1, respectively, and were 8.2 and 1.7 times higher, respectively, than the consumption rates found in 2013. Methylphenidate was detected in the influent and effluent samples at mean concentrations of 2.7 and 2.6 ng L-1, respectively, but the methylphenidate consumption rate could not be estimated because of the low excretion rate for humans (<1%). SN - 1873-3336 UR - https://www.unboundmedicine.com/medline/citation/32388180/Evaluation_of_pharmaceutical_abuse_and_illicit_drug_use_in_South_Korea_by_wastewater-based_epidemiology L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3894(20)30611-7 DB - PRIME DP - Unbound Medicine ER -
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