Tags

Type your tag names separated by a space and hit enter

Effects of Bidens gardneri Baker leaves aqueous extract in glucose homeostasis of rats.
Biomed Pharmacother. 2020 Jul; 127:110185.BP

Abstract

Bidens gardneri Baker, popularly known as "picão-vermelho", has been used, traditionally, as a medicinal plant for the treatment of Diabetes mellitus. This study aimed to evaluate antidiabetic effect of leaves from B. gardneri aqueous extract (BGAE). We also evaluated in vitro anti-glycation potential. Chemical composition was analyzed based on a colorimetrics and HPLC methods. The oral glucose tolerance test (OGTT), was performed in rats with different doses (30, 100 and 300 mg/kg). Alloxan-induced diabetic and hypercaloric diet-fed rats were treated with 300 mg/kg of BGAE, orally, for 10 days and then 10 weeks, respectively. The activity of intestinal disaccharidases (maltase, sucrase and lactase) and quantification of muscle and liver glycogen content were also evaluated. On chemical analysis, the extract showed high phenolics content and the chromatogram showed 4-O-caffeoylquinic acid as the major component. The extract presented inhibition in the formation of advanced glycation end products (AGEs) and disaccharidases activity. In OGTT the dose of 300 mg/kg significantly decreased the blood glucose. In diabetic animals, BGAE significantly decreased blood glucose levels, preventing weight loss. In addition, in hypercaloric diet-fed rats, the extract prevented hyperglycemia. Our results suggest that, aqueous extract of B. gardneri has a potential for therapeutic intervention of diabetes.

Authors+Show Affiliations

Faculty of Health Sciences, Federal University of Grande Dourados, Dourados, MS, Brazil.Faculty of Health Sciences, Federal University of Grande Dourados, Dourados, MS, Brazil.Faculty of Health Sciences, Federal University of Grande Dourados, Dourados, MS, Brazil.Faculty of Health Sciences, Federal University of Grande Dourados, Dourados, MS, Brazil.Faculty of Health Sciences, Federal University of Grande Dourados, Dourados, MS, Brazil.Faculty of Health Sciences, Federal University of Grande Dourados, Dourados, MS, Brazil.Laboratório de Farmacognosia, Programa de Pós-Graduação em Biotecnologia e Biociências, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil.Laboratório de Farmacognosia, Programa de Pós-Graduação em Biotecnologia e Biociências, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil.Faculty of Health Sciences, Federal University of Grande Dourados, Dourados, MS, Brazil.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32388239

Citation

Félix, Jéssica Maria, et al. "Effects of Bidens Gardneri Baker Leaves Aqueous Extract in Glucose Homeostasis of Rats." Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, vol. 127, 2020, p. 110185.
Félix JM, Bertoncello LA, Alves MCDA, et al. Effects of Bidens gardneri Baker leaves aqueous extract in glucose homeostasis of rats. Biomed Pharmacother. 2020;127:110185.
Félix, J. M., Bertoncello, L. A., Alves, M. C. D. A., de Miranda Pedroso, T. F., Dos Santos, R. C., Formagio, A. S. N., Chaves, V. C., Reginatto, F. H., & Trichez, V. D. K. (2020). Effects of Bidens gardneri Baker leaves aqueous extract in glucose homeostasis of rats. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, 127, 110185. https://doi.org/10.1016/j.biopha.2020.110185
Félix JM, et al. Effects of Bidens Gardneri Baker Leaves Aqueous Extract in Glucose Homeostasis of Rats. Biomed Pharmacother. 2020;127:110185. PubMed PMID: 32388239.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of Bidens gardneri Baker leaves aqueous extract in glucose homeostasis of rats. AU - Félix,Jéssica Maria, AU - Bertoncello,Luana Ale, AU - Alves,Mikelly Cristina do Amaral, AU - de Miranda Pedroso,Thiago Félix, AU - Dos Santos,Rafael Claudino, AU - Formagio,Anelise Samara Nazari, AU - Chaves,Vitor Clasen, AU - Reginatto,Flávio Henrique, AU - Trichez,Virginia Demarchi Kappel, Y1 - 2020/05/07/ PY - 2020/01/24/received PY - 2020/04/09/revised PY - 2020/04/17/accepted PY - 2020/5/11/pubmed PY - 2020/5/11/medline PY - 2020/5/11/entrez KW - Diabetes mellitus KW - Disaccharidases. KW - Glycation KW - Phenolic KW - Picão-vermelho SP - 110185 EP - 110185 JF - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie JO - Biomed. Pharmacother. VL - 127 N2 - Bidens gardneri Baker, popularly known as "picão-vermelho", has been used, traditionally, as a medicinal plant for the treatment of Diabetes mellitus. This study aimed to evaluate antidiabetic effect of leaves from B. gardneri aqueous extract (BGAE). We also evaluated in vitro anti-glycation potential. Chemical composition was analyzed based on a colorimetrics and HPLC methods. The oral glucose tolerance test (OGTT), was performed in rats with different doses (30, 100 and 300 mg/kg). Alloxan-induced diabetic and hypercaloric diet-fed rats were treated with 300 mg/kg of BGAE, orally, for 10 days and then 10 weeks, respectively. The activity of intestinal disaccharidases (maltase, sucrase and lactase) and quantification of muscle and liver glycogen content were also evaluated. On chemical analysis, the extract showed high phenolics content and the chromatogram showed 4-O-caffeoylquinic acid as the major component. The extract presented inhibition in the formation of advanced glycation end products (AGEs) and disaccharidases activity. In OGTT the dose of 300 mg/kg significantly decreased the blood glucose. In diabetic animals, BGAE significantly decreased blood glucose levels, preventing weight loss. In addition, in hypercaloric diet-fed rats, the extract prevented hyperglycemia. Our results suggest that, aqueous extract of B. gardneri has a potential for therapeutic intervention of diabetes. SN - 1950-6007 UR - https://www.unboundmedicine.com/medline/citation/32388239/Effects_of_Bidens_gardneri_Baker_leaves_aqueous_extract_in_glucose_homeostasis_of_rats L2 - https://linkinghub.elsevier.com/retrieve/pii/S0753-3322(20)30377-2 DB - PRIME DP - Unbound Medicine ER -