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Gastrointestinal, hepatobiliary, and pancreatic manifestations of COVID-19.
J Clin Virol. 2020 07; 128:104386.JC

Abstract

There is an increasing number of confirmed cases and deaths caused by the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contributing to the Coronavirus disease 2019 (COVID-19) pandemic. At this point, the need for further disease characterization is critical. COVID-19 is well established as a respiratory tract pathogen; however, recent studies have shown an increasing number of patients reporting gastrointestinal manifestations such as diarrhea, nausea, vomiting, and abdominal pain. The time from onset of gastrointestinal symptoms to hospital presentation is often delayed compared to that of respiratory symptoms. It has been noted that SARS-CoV-2 RNA can be detected in fecal matter for an extended period of time, even after respiratory samples have tested negative and patients are asymptomatic. In this article, SARS-CoV-2 and its disease COVID-19 will be reviewed with consideration of the latest literature about gastrointestinal symptomatology, the mechanisms by which the virus may inflict damage, and the possibility of viral replication contributing to a fecal-oral route of transmission.

Authors+Show Affiliations

Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA.Nova Southeastern University Kiran C. Patel College of Osteopathic Medicine, Fort Lauderdale, FL, USA.Division of Hospital Medicine, Penn State Health Milton S. Hershey Medical Center, Hershey, PA, USA.Department of Gastroenterology and Hepatology, University of Nebraska Medical Center, Omaha, NE, USA.Division of Hospital Medicine, Penn State Health Milton S. Hershey Medical Center, Hershey, PA, USA.University of Nebraska College of Medicine, Omaha, NE, USA.Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA. Electronic address: srinivas.vunnam@unmc.edu.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32388469

Citation

Patel, Kishan P., et al. "Gastrointestinal, Hepatobiliary, and Pancreatic Manifestations of COVID-19." Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology, vol. 128, 2020, p. 104386.
Patel KP, Patel PA, Vunnam RR, et al. Gastrointestinal, hepatobiliary, and pancreatic manifestations of COVID-19. J Clin Virol. 2020;128:104386.
Patel, K. P., Patel, P. A., Vunnam, R. R., Hewlett, A. T., Jain, R., Jing, R., & Vunnam, S. R. (2020). Gastrointestinal, hepatobiliary, and pancreatic manifestations of COVID-19. Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology, 128, 104386. https://doi.org/10.1016/j.jcv.2020.104386
Patel KP, et al. Gastrointestinal, Hepatobiliary, and Pancreatic Manifestations of COVID-19. J Clin Virol. 2020;128:104386. PubMed PMID: 32388469.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gastrointestinal, hepatobiliary, and pancreatic manifestations of COVID-19. AU - Patel,Kishan P, AU - Patel,Puja A, AU - Vunnam,Rama R, AU - Hewlett,Alexander T, AU - Jain,Rohit, AU - Jing,Ran, AU - Vunnam,Srinivas R, Y1 - 2020/04/29/ PY - 2020/04/18/received PY - 2020/04/25/accepted PY - 2020/5/11/pubmed PY - 2020/7/7/medline PY - 2020/5/11/entrez KW - COVID 19 KW - Gastrointestinal KW - Hepatobiliary KW - Pandemic KW - SARS-CoV-2 SP - 104386 EP - 104386 JF - Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology JO - J Clin Virol VL - 128 N2 - There is an increasing number of confirmed cases and deaths caused by the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contributing to the Coronavirus disease 2019 (COVID-19) pandemic. At this point, the need for further disease characterization is critical. COVID-19 is well established as a respiratory tract pathogen; however, recent studies have shown an increasing number of patients reporting gastrointestinal manifestations such as diarrhea, nausea, vomiting, and abdominal pain. The time from onset of gastrointestinal symptoms to hospital presentation is often delayed compared to that of respiratory symptoms. It has been noted that SARS-CoV-2 RNA can be detected in fecal matter for an extended period of time, even after respiratory samples have tested negative and patients are asymptomatic. In this article, SARS-CoV-2 and its disease COVID-19 will be reviewed with consideration of the latest literature about gastrointestinal symptomatology, the mechanisms by which the virus may inflict damage, and the possibility of viral replication contributing to a fecal-oral route of transmission. SN - 1873-5967 UR - https://www.unboundmedicine.com/medline/citation/32388469/Gastrointestinal_hepatobiliary_and_pancreatic_manifestations_of_COVID_19_ DB - PRIME DP - Unbound Medicine ER -