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The implications of preliminary screening and diagnosis: Clinical characteristics of 33 mild patients with SARS-CoV-2 infection in Hunan, China.
J Clin Virol. 2020 07; 128:104397.JC

Abstract

BACKGROUND

In December 2019, coronavirus Disease 2019 (COVID-19) occurred in Wuhan, Hubei Province, China. The disease has rapidly spread from Wuhan to other regions.

OBJECTIVES

To describe the clinical manifestations and epidemiological characteristics of patients with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection in Hunan Province in 2020.

STUDY DESIGN

From January 19 to February 7, 2020, 33 patients with positive in nucleic acid test of pharyngeal swab were retrospectively collected and analyzed.

RESULTS

There are 33 COVID-19 patients (16 male, 17 female), and the median age was 46 years. Nineteen patients (48 %) were associated with a family cluster outbreak. Seventeen patients (52 %) had traveled or lived in Hubei Province. These patients are early mild cases, most common symptoms are fever [23 (70 %)] and cough [13 (39 %)]. Most patients' white blood cell counts are normal, while they manifest as significant reduction in lymphocytes [17/28 (61 %)]. The levels of c-reactive protein and erythrocyte sedimentation rate suggest a typical viral infection. Procalcitonin did not increase and D-dimer increased slightly. Lactate dehydrogenase (LDH) levels have elevated in most patients. CT images of these patients showed bilateral multiple plaques or nodular ground-glass opacities (68.4 %). Fecal nucleic acid results were positive in eight COVID-19 patients accompanied with diarrhea. Tear nucleic acid results were negative in six COVID-19 patients. And four asymptomatic patients were infected with SARS-CoV-2.

CONCLUSIONS

The clinical symptoms, laboratory results and imaging reports of patients with COVID-19 in Hunan area are significantly different from those in Wuhan area. For non-Wuhan epidemic areas, more attention should be paid to nucleic acid test results of throat swabs and stools, and it is not easily to diagnose based on clinical symptoms and CT results. Reduced whole blood lymph count can be used as an adjuvant diagnosis of early SARS-CoV-2 infection. Attention should be paid to asymptomatic carriers, which is of great significance for the control of the global epidemic.

Authors+Show Affiliations

Department of Laboratory Medicine, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China.Department of Laboratory Medicine, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China.Department of Laboratory Medicine, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China.Department of Laboratory Medicine, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China.Department of Laboratory Medicine, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China.Department of Laboratory Medicine, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China.Department of Laboratory Medicine, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China.Department of Laboratory Medicine, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China. Electronic address: wangmin0000@csu.edu.cn.Department of Laboratory Medicine, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China. Electronic address: wangwenlong@csu.edu.cn.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

32388472

Citation

Yin, Sheng, et al. "The Implications of Preliminary Screening and Diagnosis: Clinical Characteristics of 33 Mild Patients With SARS-CoV-2 Infection in Hunan, China." Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology, vol. 128, 2020, p. 104397.
Yin S, Peng Y, Ren Y, et al. The implications of preliminary screening and diagnosis: Clinical characteristics of 33 mild patients with SARS-CoV-2 infection in Hunan, China. J Clin Virol. 2020;128:104397.
Yin, S., Peng, Y., Ren, Y., Hu, M., Tang, L., Xiang, Z., Li, X., Wang, M., & Wang, W. (2020). The implications of preliminary screening and diagnosis: Clinical characteristics of 33 mild patients with SARS-CoV-2 infection in Hunan, China. Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology, 128, 104397. https://doi.org/10.1016/j.jcv.2020.104397
Yin S, et al. The Implications of Preliminary Screening and Diagnosis: Clinical Characteristics of 33 Mild Patients With SARS-CoV-2 Infection in Hunan, China. J Clin Virol. 2020;128:104397. PubMed PMID: 32388472.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The implications of preliminary screening and diagnosis: Clinical characteristics of 33 mild patients with SARS-CoV-2 infection in Hunan, China. AU - Yin,Sheng, AU - Peng,Yizhi, AU - Ren,Yaping, AU - Hu,Min, AU - Tang,Lingli, AU - Xiang,Zhongyuan, AU - Li,Xianping, AU - Wang,Min, AU - Wang,Wenlong, Y1 - 2020/04/30/ PY - 2020/03/04/received PY - 2020/04/08/revised PY - 2020/04/27/accepted PY - 2020/5/11/pubmed PY - 2020/7/7/medline PY - 2020/5/11/entrez KW - COVID-19 KW - China KW - Clinical features KW - Hunan KW - SARS-CoV-2 SP - 104397 EP - 104397 JF - Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology JO - J Clin Virol VL - 128 N2 - BACKGROUND: In December 2019, coronavirus Disease 2019 (COVID-19) occurred in Wuhan, Hubei Province, China. The disease has rapidly spread from Wuhan to other regions. OBJECTIVES: To describe the clinical manifestations and epidemiological characteristics of patients with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection in Hunan Province in 2020. STUDY DESIGN: From January 19 to February 7, 2020, 33 patients with positive in nucleic acid test of pharyngeal swab were retrospectively collected and analyzed. RESULTS: There are 33 COVID-19 patients (16 male, 17 female), and the median age was 46 years. Nineteen patients (48 %) were associated with a family cluster outbreak. Seventeen patients (52 %) had traveled or lived in Hubei Province. These patients are early mild cases, most common symptoms are fever [23 (70 %)] and cough [13 (39 %)]. Most patients' white blood cell counts are normal, while they manifest as significant reduction in lymphocytes [17/28 (61 %)]. The levels of c-reactive protein and erythrocyte sedimentation rate suggest a typical viral infection. Procalcitonin did not increase and D-dimer increased slightly. Lactate dehydrogenase (LDH) levels have elevated in most patients. CT images of these patients showed bilateral multiple plaques or nodular ground-glass opacities (68.4 %). Fecal nucleic acid results were positive in eight COVID-19 patients accompanied with diarrhea. Tear nucleic acid results were negative in six COVID-19 patients. And four asymptomatic patients were infected with SARS-CoV-2. CONCLUSIONS: The clinical symptoms, laboratory results and imaging reports of patients with COVID-19 in Hunan area are significantly different from those in Wuhan area. For non-Wuhan epidemic areas, more attention should be paid to nucleic acid test results of throat swabs and stools, and it is not easily to diagnose based on clinical symptoms and CT results. Reduced whole blood lymph count can be used as an adjuvant diagnosis of early SARS-CoV-2 infection. Attention should be paid to asymptomatic carriers, which is of great significance for the control of the global epidemic. SN - 1873-5967 UR - https://www.unboundmedicine.com/medline/citation/32388472/The_implications_of_preliminary_screening_and_diagnosis:_Clinical_characteristics_of_33_mild_patients_with_SARS_CoV_2_infection_in_Hunan_China_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1386-6532(20)30139-6 DB - PRIME DP - Unbound Medicine ER -