Tags

Type your tag names separated by a space and hit enter

Screening of healthcare workers for SARS-CoV-2 highlights the role of asymptomatic carriage in COVID-19 transmission.
Elife. 2020 05 11; 9E

Abstract

Significant differences exist in the availability of healthcare worker (HCW) SARS-CoV-2 testing between countries, and existing programmes focus on screening symptomatic rather than asymptomatic staff. Over a 3 week period (April 2020), 1032 asymptomatic HCWs were screened for SARS-CoV-2 in a large UK teaching hospital. Symptomatic staff and symptomatic household contacts were additionally tested. Real-time RT-PCR was used to detect viral RNA from a throat+nose self-swab. 3% of HCWs in the asymptomatic screening group tested positive for SARS-CoV-2. 17/30 (57%) were truly asymptomatic/pauci-symptomatic. 12/30 (40%) had experienced symptoms compatible with coronavirus disease 2019 (COVID-19)>7 days prior to testing, most self-isolating, returning well. Clusters of HCW infection were discovered on two independent wards. Viral genome sequencing showed that the majority of HCWs had the dominant lineage B∙1. Our data demonstrates the utility of comprehensive screening of HCWs with minimal or no symptoms. This approach will be critical for protecting patients and hospital staff.

Authors+Show Affiliations

Department of Infectious Diseases, Cambridge University NHS Hospitals Foundation Trust, Cambridge, United Kingdom. Clinical Microbiology and Public Health Laboratory, Public Health England, Cambridge, United Kingdom.Wellcome Sanger Institute, Hinxton, United Kingdom. Department of Medicine, University of Cambridge, Cambridge, United Kingdom. Cambridge Institute of Therapeutic Immunology and Infectious Disease (CITIID), Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom.Department of Infectious Diseases, Cambridge University NHS Hospitals Foundation Trust, Cambridge, United Kingdom. Clinical Microbiology and Public Health Laboratory, Public Health England, Cambridge, United Kingdom.Department of Infectious Diseases, Cambridge University NHS Hospitals Foundation Trust, Cambridge, United Kingdom. Clinical Microbiology and Public Health Laboratory, Public Health England, Cambridge, United Kingdom.Department of Infectious Diseases, Cambridge University NHS Hospitals Foundation Trust, Cambridge, United Kingdom. Clinical Microbiology and Public Health Laboratory, Public Health England, Cambridge, United Kingdom. Department of Medicine, University of Cambridge, Cambridge, United Kingdom. Cambridge Institute of Therapeutic Immunology and Infectious Disease (CITIID), Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom.Department of Medicine, University of Cambridge, Cambridge, United Kingdom. Cambridge Institute of Therapeutic Immunology and Infectious Disease (CITIID), Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom.Academic Department of Medical Genetics, University of Cambridge, Cambridge, United Kingdom.Department of Medicine, University of Cambridge, Cambridge, United Kingdom. Cambridge Institute of Therapeutic Immunology and Infectious Disease (CITIID), Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom.Department of Infectious Diseases, Cambridge University NHS Hospitals Foundation Trust, Cambridge, United Kingdom. Clinical Microbiology and Public Health Laboratory, Public Health England, Cambridge, United Kingdom.Occupational Health and Wellbeing, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom.Cambridge Institute of Therapeutic Immunology and Infectious Disease (CITIID), Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom. Department of Microbiology, Cambridge University NHS Hospitals Foundation Trust, Cambridge, United Kingdom.Division of Virology, Department of Pathology, University of Cambridge, Cambridge, United Kingdom.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableClinical Microbiology and Public Health Laboratory, Public Health England, Cambridge, United Kingdom.National Institutes for Health Research Cambridge, Clinical Research Facility, Cambridge, United Kingdom.Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom.National Institutes for Health Research Cambridge, Clinical Research Facility, Cambridge, United Kingdom.Statistical Laboratory, Centre for Mathematical Sciences, Cambridge, United Kingdom.Department of Medicine, University of Cambridge, Cambridge, United Kingdom. National Institutes for Health Research Cambridge Biomedical Research Centre, Cambridge, United Kingdom.Department of Medicine, University of Cambridge, Cambridge, United Kingdom. Cambridge Institute of Therapeutic Immunology and Infectious Disease (CITIID), Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom.Department of Medicine, University of Cambridge, Cambridge, United Kingdom. Cambridge Institute of Therapeutic Immunology and Infectious Disease (CITIID), Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom.Department of Infectious Diseases, Cambridge University NHS Hospitals Foundation Trust, Cambridge, United Kingdom. Department of Medicine, University of Cambridge, Cambridge, United Kingdom. Cambridge Institute of Therapeutic Immunology and Infectious Disease (CITIID), Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom.Department of Infectious Diseases, Cambridge University NHS Hospitals Foundation Trust, Cambridge, United Kingdom. Department of Medicine, University of Cambridge, Cambridge, United Kingdom. Cambridge Institute of Therapeutic Immunology and Infectious Disease (CITIID), Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom. NHS Blood and Transplant, Cambridge, United Kingdom.Occupational Health and Wellbeing, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom.Division of Virology, Department of Pathology, University of Cambridge, Cambridge, United Kingdom.Department of Medicine, University of Cambridge, Cambridge, United Kingdom. Cambridge Institute of Therapeutic Immunology and Infectious Disease (CITIID), Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom.Department of Infectious Diseases, Cambridge University NHS Hospitals Foundation Trust, Cambridge, United Kingdom. Department of Medicine, University of Cambridge, Cambridge, United Kingdom. Cambridge Institute of Therapeutic Immunology and Infectious Disease (CITIID), Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

32392129

Citation

Rivett, Lucy, et al. "Screening of Healthcare Workers for SARS-CoV-2 Highlights the Role of Asymptomatic Carriage in COVID-19 Transmission." ELife, vol. 9, 2020.
Rivett L, Sridhar S, Sparkes D, et al. Screening of healthcare workers for SARS-CoV-2 highlights the role of asymptomatic carriage in COVID-19 transmission. Elife. 2020;9.
Rivett, L., Sridhar, S., Sparkes, D., Routledge, M., Jones, N. K., Forrest, S., Young, J., Pereira-Dias, J., Hamilton, W. L., Ferris, M., Torok, M. E., Meredith, L., Gupta, R., Lyons, P. A., Toshner, M., Warne, B., Bartholdson Scott, J., Cormie, C., Gill, H., ... Weekes, M. P. (2020). Screening of healthcare workers for SARS-CoV-2 highlights the role of asymptomatic carriage in COVID-19 transmission. ELife, 9. https://doi.org/10.7554/eLife.58728
Rivett L, et al. Screening of Healthcare Workers for SARS-CoV-2 Highlights the Role of Asymptomatic Carriage in COVID-19 Transmission. Elife. 2020 05 11;9 PubMed PMID: 32392129.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Screening of healthcare workers for SARS-CoV-2 highlights the role of asymptomatic carriage in COVID-19 transmission. AU - Rivett,Lucy, AU - Sridhar,Sushmita, AU - Sparkes,Dominic, AU - Routledge,Matthew, AU - Jones,Nick K, AU - Forrest,Sally, AU - Young,Jamie, AU - Pereira-Dias,Joana, AU - Hamilton,William L, AU - Ferris,Mark, AU - Torok,M Estee, AU - Meredith,Luke, AU - ,, AU - Gupta,Ravi, AU - Lyons,Paul A, AU - Toshner,Mark, AU - Warne,Ben, AU - Bartholdson Scott,Josefin, AU - Cormie,Claire, AU - Gill,Harmeet, AU - Kean,Iain, AU - Maes,Mailis, AU - Reynolds,Nicola, AU - Wantoch,Michelle, AU - Caddy,Sarah, AU - Caller,Laura, AU - Feltwell,Theresa, AU - Hall,Grant, AU - Hosmillo,Myra, AU - Houldcroft,Charlotte, AU - Jahun,Aminu, AU - Khokhar,Fahad, AU - Yakovleva,Anna, AU - Butcher,Helen, AU - Caputo,Daniela, AU - Clapham-Riley,Debra, AU - Dolling,Helen, AU - Furlong,Anita, AU - Graves,Barbara, AU - Gresley,Emma Le, AU - Kingston,Nathalie, AU - Papadia,Sofia, AU - Stark,Hannah, AU - Stirrups,Kathleen E, AU - Webster,Jennifer, AU - Calder,Joanna, AU - Harris,Julie, AU - Hewitt,Sarah, AU - Kennet,Jane, AU - Meadows,Anne, AU - Rastall,Rebecca, AU - Brien,Criona O, AU - Price,Jo, AU - Publico,Cherry, AU - Rowlands,Jane, AU - Ruffolo,Valentina, AU - Tordesillas,Hugo, AU - Brookes,Karen, AU - Canna,Laura, AU - Cruz,Isabel, AU - Dempsey,Katie, AU - Elmer,Anne, AU - Escoffery,Naidine, AU - Jones,Heather, AU - Ribeiro,Carla, AU - Saunders,Caroline, AU - Wright,Angela, AU - Nyagumbo,Rutendo, AU - Roberts,Anne, AU - Bucke,Ashlea, AU - Hargreaves,Simone, AU - Johnson,Danielle, AU - Narcorda,Aileen, AU - Read,Debbie, AU - Sparke,Christian, AU - Warboys,Lucy, AU - Lagadu,Kirsty, AU - Mactavous,Lenette, AU - Gould,Tim, AU - Raine,Tim, AU - Mather,Claire, AU - Ramenatte,Nicola, AU - Vallier,Anne-Laure, AU - Kasanicki,Mary, AU - Eames,Penelope-Jane, AU - McNicholas,Chris, AU - Thake,Lisa, AU - Bartholomew,Neil, AU - Brown,Nick, AU - Parmar,Surendra, AU - Zhang,Hongyi, AU - Bowring,Ailsa, AU - Martell,Geraldine, AU - Quinnell,Natalie, AU - Wright,Jo, AU - Murphy,Helen, AU - Dunmore,Benjamin J, AU - Legchenko,Ekaterina, AU - Gräf,Stefan, AU - Huang,Christopher, AU - Hodgson,Josh, AU - Hunter,Kelvin, AU - Martin,Jennifer, AU - Mescia,Federica, AU - O'Donnell,Ciara, AU - Pointon,Linda, AU - Shih,Joy, AU - Sutcliffe,Rachel, AU - Tilly,Tobias, AU - Tong,Zhen, AU - Treacy,Carmen, AU - Wood,Jennifer, AU - Bergamaschi,Laura, AU - Betancourt,Ariana, AU - Bowyer,Georgie, AU - De Sa,Aloka, AU - Epping,Maddie, AU - Hinch,Andrew, AU - Huhn,Oisin, AU - Jarvis,Isobel, AU - Lewis,Daniel, AU - Marsden,Joe, AU - McCallum,Simon, AU - Nice,Francescsa, AU - Curran,Martin D, AU - Fuller,Stewart, AU - Chaudhry,Afzal, AU - Shaw,Ashley, AU - Samworth,Richard J, AU - Bradley,John R, AU - Dougan,Gordon, AU - Smith,Kenneth Gc, AU - Lehner,Paul J, AU - Matheson,Nicholas J, AU - Wright,Giles, AU - Goodfellow,Ian G, AU - Baker,Stephen, AU - Weekes,Michael P, Y1 - 2020/05/11/ PY - 2020/05/08/received PY - 2020/05/10/accepted PY - 2020/5/12/pubmed PY - 2020/7/1/medline PY - 2020/5/12/entrez KW - COVID-19 KW - SARS-CoV-2 KW - emerging pathogens KW - epidemiology KW - global health KW - human KW - human biology KW - infectious disease KW - medicine KW - occupational health KW - virology KW - virus JF - eLife JO - Elife VL - 9 N2 - Significant differences exist in the availability of healthcare worker (HCW) SARS-CoV-2 testing between countries, and existing programmes focus on screening symptomatic rather than asymptomatic staff. Over a 3 week period (April 2020), 1032 asymptomatic HCWs were screened for SARS-CoV-2 in a large UK teaching hospital. Symptomatic staff and symptomatic household contacts were additionally tested. Real-time RT-PCR was used to detect viral RNA from a throat+nose self-swab. 3% of HCWs in the asymptomatic screening group tested positive for SARS-CoV-2. 17/30 (57%) were truly asymptomatic/pauci-symptomatic. 12/30 (40%) had experienced symptoms compatible with coronavirus disease 2019 (COVID-19)>7 days prior to testing, most self-isolating, returning well. Clusters of HCW infection were discovered on two independent wards. Viral genome sequencing showed that the majority of HCWs had the dominant lineage B∙1. Our data demonstrates the utility of comprehensive screening of HCWs with minimal or no symptoms. This approach will be critical for protecting patients and hospital staff. SN - 2050-084X UR - https://www.unboundmedicine.com/medline/citation/32392129/Screening_of_healthcare_workers_for_SARS_CoV_2_highlights_the_role_of_asymptomatic_carriage_in_COVID_19_transmission_ L2 - https://doi.org/10.7554/eLife.58728 DB - PRIME DP - Unbound Medicine ER -