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Recent advances of therapeutic targets and potential drugs of COVID-19.
Pharmazie. 2020 05 01; 75(5):161-163.P

Abstract

Since December 2019, numerous cases of coronavirus disease 2019 (COVID-19) caused by the infection of the novel coronavirus (2019-nCoV) have been confirmed in Wuhan, China. The outbreak of 2019-nCoV in China embodied a significant and urgent threat to global health. 2019-nCoV was a new, highly contagious coronavirus discovered following the outbreak of SARS coronavirus (SARS-CoV) and MERS coronavirus (MERS-CoV). The novel coronavirus can cause severe respiratory disease and even death. However, no specific therapeutic drugs have been developed clinically thus far. This article examines the potential of therapeutic drugs by assessing the structure of 2019-nCoV, its mechanism in invading host cells, and the anti-viral mechanism of the human autoimmune system. We also review the latest research regarding the progress of potential therapeutic drugs and provide references for new drug developments of COVID-19.

Authors+Show Affiliations

Henan Provincial Key Laboratory of Children's Genetics and Metabolic Diseases, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, China; Children's Hospital Affiliated of Zhengzhou University; Department of Pediatric Oncology Surgery, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, China;, Email: zhangwancun@126.com.Henan Provincial Key Laboratory of Children's Genetics and Metabolic Diseases, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, China.Henan Provincial Key Laboratory of Children's Genetics and Metabolic Diseases, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, China.Henan Provincial Key Laboratory of Children's Genetics and Metabolic Diseases, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, China.Children's Hospital Affiliated of Zhengzhou University; Department of Pharmacy, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, China;, Email: cjh070310216@163.com.Children's Hospital Affiliated of Zhengzhou University; Department of Pediatric Oncology Surgery, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, China;, Email: zhangxw956658@163.com.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

32393419

Citation

Zhang, W, et al. "Recent Advances of Therapeutic Targets and Potential Drugs of COVID-19." Die Pharmazie, vol. 75, no. 5, 2020, pp. 161-163.
Zhang W, Zhang P, Wang G, et al. Recent advances of therapeutic targets and potential drugs of COVID-19. Pharmazie. 2020;75(5):161-163.
Zhang, W., Zhang, P., Wang, G., Cheng, W., Chen, J., & Zhang, X. (2020). Recent advances of therapeutic targets and potential drugs of COVID-19. Die Pharmazie, 75(5), 161-163. https://doi.org/10.1691/ph.2020.0431
Zhang W, et al. Recent Advances of Therapeutic Targets and Potential Drugs of COVID-19. Pharmazie. 2020 05 1;75(5):161-163. PubMed PMID: 32393419.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Recent advances of therapeutic targets and potential drugs of COVID-19. AU - Zhang,W, AU - Zhang,P, AU - Wang,G, AU - Cheng,W, AU - Chen,J, AU - Zhang,X, PY - 2020/5/13/entrez PY - 2020/5/13/pubmed PY - 2020/5/15/medline SP - 161 EP - 163 JF - Die Pharmazie JO - Pharmazie VL - 75 IS - 5 N2 - Since December 2019, numerous cases of coronavirus disease 2019 (COVID-19) caused by the infection of the novel coronavirus (2019-nCoV) have been confirmed in Wuhan, China. The outbreak of 2019-nCoV in China embodied a significant and urgent threat to global health. 2019-nCoV was a new, highly contagious coronavirus discovered following the outbreak of SARS coronavirus (SARS-CoV) and MERS coronavirus (MERS-CoV). The novel coronavirus can cause severe respiratory disease and even death. However, no specific therapeutic drugs have been developed clinically thus far. This article examines the potential of therapeutic drugs by assessing the structure of 2019-nCoV, its mechanism in invading host cells, and the anti-viral mechanism of the human autoimmune system. We also review the latest research regarding the progress of potential therapeutic drugs and provide references for new drug developments of COVID-19. SN - 0031-7144 UR - https://www.unboundmedicine.com/medline/citation/32393419/Recent_advances_of_therapeutic_targets_and_potential_drugs_of_COVID_19_ L2 - https://www.ingentaconnect.com/openurl?genre=article&issn=0031-7144&volume=75&issue=5&spage=161&aulast=Zhang DB - PRIME DP - Unbound Medicine ER -