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An Update on Current Therapeutic Drugs Treating COVID-19.
Curr Pharmacol Rep. 2020 May 11 [Online ahead of print]CP

Abstract

The current pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has presented unprecedented challenges to the healthcare systems in almost every country around the world. Currently, there are no proven effective vaccines or therapeutic agents against the virus. Current clinical management includes infection prevention and control measures and supportive care including supplemental oxygen and mechanical ventilatory support. Evolving research and clinical data regarding the virologic SARS-CoV-2 suggest a potential list of repurposed drugs with appropriate pharmacological effects and therapeutic efficacies in treating COVID-19 patients. In this review, we will update and summarize the most common and plausible drugs for the treatment of COVID-19 patients. These drugs and therapeutic agents include antiviral agents (remdesivir, hydroxychloroquine, chloroquine, lopinavir, umifenovir, favipiravir, and oseltamivir), and supporting agents (Ascorbic acid, Azithromycin, Corticosteroids, Nitric oxide, IL-6 antagonists), among others. We hope that this review will provide useful and most updated therapeutic drugs to prevent, control, and treat COVID-19 patients until the approval of vaccines and specific drugs targeting SARS-CoV-2.

Authors+Show Affiliations

1Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854 USA.1Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854 USA.1Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854 USA.1Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854 USA.1Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854 USA.1Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854 USA.1Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854 USA.1Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854 USA.1Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854 USA. 2Department of Pharmacology, School of Basic Medical Science, Lanzhou University, Lanzhou, 730000 China.1Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854 USA. 3Department of Food and Pharmaceutical Engineering, Guiyang University, Guiyang, 550005 China.4Robert Wood Johnson University Hospital Somerset, Somerville, NJ 08876 USA. 5Robert Wood Johnson Medical School, New Brunswick, NJ 08901 USA.5Robert Wood Johnson Medical School, New Brunswick, NJ 08901 USA.4Robert Wood Johnson University Hospital Somerset, Somerville, NJ 08876 USA. 6Department of Pharmacy Practice, Ernest Mario School of Pharmacy, Piscataway, NJ 08854 USA.1Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854 USA.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32395418

Citation

Wu, Renyi, et al. "An Update On Current Therapeutic Drugs Treating COVID-19." Current Pharmacology Reports, 2020, pp. 1-15.
Wu R, Wang L, Kuo HD, et al. An Update on Current Therapeutic Drugs Treating COVID-19. Curr Pharmacol Rep. 2020.
Wu, R., Wang, L., Kuo, H. D., Shannar, A., Peter, R., Chou, P. J., Li, S., Hudlikar, R., Liu, X., Liu, Z., Poiani, G. J., Amorosa, L., Brunetti, L., & Kong, A. N. (2020). An Update on Current Therapeutic Drugs Treating COVID-19. Current Pharmacology Reports, 1-15. https://doi.org/10.1007/s40495-020-00216-7
Wu R, et al. An Update On Current Therapeutic Drugs Treating COVID-19. Curr Pharmacol Rep. 2020 May 11;1-15. PubMed PMID: 32395418.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An Update on Current Therapeutic Drugs Treating COVID-19. AU - Wu,Renyi, AU - Wang,Lujing, AU - Kuo,Hsiao-Chen Dina, AU - Shannar,Ahmad, AU - Peter,Rebecca, AU - Chou,Pochung Jordan, AU - Li,Shanyi, AU - Hudlikar,Rasika, AU - Liu,Xia, AU - Liu,Zhigang, AU - Poiani,George J, AU - Amorosa,Louis, AU - Brunetti,Luigi, AU - Kong,Ah-Ng, Y1 - 2020/05/11/ PY - 2020/5/13/entrez PY - 2020/5/13/pubmed PY - 2020/5/13/medline KW - Anakinra KW - Azithromycin KW - COVID-19 KW - Chloroquine KW - Convalescent plasma KW - Epoprostenol KW - Favipiravir KW - Hydroxychloroquine KW - Lopinavir KW - Methylprednisolone KW - Nitric oxide KW - Oseltamivir KW - Remdesivir KW - SAR-CoV-2 KW - Sarilumab KW - Sirolimus KW - Tocilizumab KW - Traditional Chinese Medicine KW - Umifenovir KW - Vitamin C SP - 1 EP - 15 JF - Current pharmacology reports JO - Curr Pharmacol Rep N2 - The current pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has presented unprecedented challenges to the healthcare systems in almost every country around the world. Currently, there are no proven effective vaccines or therapeutic agents against the virus. Current clinical management includes infection prevention and control measures and supportive care including supplemental oxygen and mechanical ventilatory support. Evolving research and clinical data regarding the virologic SARS-CoV-2 suggest a potential list of repurposed drugs with appropriate pharmacological effects and therapeutic efficacies in treating COVID-19 patients. In this review, we will update and summarize the most common and plausible drugs for the treatment of COVID-19 patients. These drugs and therapeutic agents include antiviral agents (remdesivir, hydroxychloroquine, chloroquine, lopinavir, umifenovir, favipiravir, and oseltamivir), and supporting agents (Ascorbic acid, Azithromycin, Corticosteroids, Nitric oxide, IL-6 antagonists), among others. We hope that this review will provide useful and most updated therapeutic drugs to prevent, control, and treat COVID-19 patients until the approval of vaccines and specific drugs targeting SARS-CoV-2. SN - 2198-641X UR - https://www.unboundmedicine.com/medline/citation/32395418/An_Update_on_Current_Therapeutic_Drugs_Treating_COVID_19_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/32395418/ DB - PRIME DP - Unbound Medicine ER -
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