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Data showing differential expression of Monocyte chemoattractant protein-1 in response to symptomatic and asymptomatic T. vaginalis infection.
Data Brief. 2020 Jun; 30:105628.DB

Abstract

Trichomoniasis is caused by Trichomonas vaginalis (a protozoan parasite). About 80% of the infected cases remain asymptomatic [1]. The differential response of showing symptoms or no symptoms is not yet explored. However, some studies gave us some insights on the pathogenesis of trichomonas and also about host defense mechanism. Host secretes pro-inflammatory cytokines and chemokines to evade infection. Monocyte chemoattractant protein-1 (MCP-1/CCL2) is a strong chemoattractant of monocytes, NK-cells and T-lymphocytes. Many reports have shown high MCP-1 levels during trichomonas infection [2], [3], [4], [5] in human prostate stromal myofibroblast cells (WPMY-1), HeLa cells, vaginal epithelial cells (VECs) but levels in response to symptomatic and asymptomatic isolates is not yet reported. In this article, we have reported MCP-1 levels in the vaginal washes and serum samples of BALB/c mouse infected with symptomatic and asymptomatic T. vaginalis isolates for different time points. We found higher levels of MCP-1 in vaginal washes of symptomatic group on 2nd day post infection (dpi) than control uninfected group. While on 4th dpi and 14th dpi, higher levels of MCP-1 in vaginal washes was observed in asymptomatic group as compared to control group. However, significant level of MCP-1 was observed in asymptomatic group on 14th dpi as compared to symptomatic group in vaginal washes. We have also observed significantly higher levels of MCP-1 in the serum samples of symptomatic group on 2nd, 4th and 14th dpi as compared to control group. A higher level of MCP-1 was found at all the time points in serum samples of asymptomatic group as compared to control group. Interestingly, a significant higher level of MCP-1 was found in the serum samples of BALB/c mice in asymptomatic as compared to symptomatic group. The MCP-1 levels in both vaginal washes and serum were significantly higher in asymptomatic group at later time points.

Authors+Show Affiliations

Dr. B. R. Ambedkar Center for Biomedical Research (ACBR), University of Delhi, Delhi 110007, India.Department of Medical Parasitology, PGIMER, Chandigarh 160012, India.Department of Obstetrics and Gynecology, PGIMER, Chandigarh 160012, India.Stem cell laboratory, SMiLE incubator, Scheelevägen 2, 22381 Lund, Sweden.Assistant Professor, Dr. B. R. Ambedkar Centre for Biomedical Research, University of Delhi, Delhi 110007, India.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32395589

Citation

Yadav, Sonal, et al. "Data Showing Differential Expression of Monocyte Chemoattractant Protein-1 in Response to Symptomatic and Asymptomatic T. Vaginalis Infection." Data in Brief, vol. 30, 2020, p. 105628.
Yadav S, Khurana S, Bagga R, et al. Data showing differential expression of Monocyte chemoattractant protein-1 in response to symptomatic and asymptomatic T. vaginalis infection. Data Brief. 2020;30:105628.
Yadav, S., Khurana, S., Bagga, R., Dhanda, R. S., & Yadav, M. (2020). Data showing differential expression of Monocyte chemoattractant protein-1 in response to symptomatic and asymptomatic T. vaginalis infection. Data in Brief, 30, 105628. https://doi.org/10.1016/j.dib.2020.105628
Yadav S, et al. Data Showing Differential Expression of Monocyte Chemoattractant Protein-1 in Response to Symptomatic and Asymptomatic T. Vaginalis Infection. Data Brief. 2020;30:105628. PubMed PMID: 32395589.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Data showing differential expression of Monocyte chemoattractant protein-1 in response to symptomatic and asymptomatic T. vaginalis infection. AU - Yadav,Sonal, AU - Khurana,Sumeeta, AU - Bagga,Rashmi, AU - Dhanda,Rakesh Singh, AU - Yadav,Manisha, Y1 - 2020/04/28/ PY - 2020/04/03/received PY - 2020/04/20/revised PY - 2020/04/21/accepted PY - 2020/5/13/entrez PY - 2020/5/13/pubmed PY - 2020/5/13/medline KW - Asymptomatic KW - MCP-1/CCL-2 KW - Symptomatic KW - Trichomonas vaginalis SP - 105628 EP - 105628 JF - Data in brief JO - Data Brief VL - 30 N2 - Trichomoniasis is caused by Trichomonas vaginalis (a protozoan parasite). About 80% of the infected cases remain asymptomatic [1]. The differential response of showing symptoms or no symptoms is not yet explored. However, some studies gave us some insights on the pathogenesis of trichomonas and also about host defense mechanism. Host secretes pro-inflammatory cytokines and chemokines to evade infection. Monocyte chemoattractant protein-1 (MCP-1/CCL2) is a strong chemoattractant of monocytes, NK-cells and T-lymphocytes. Many reports have shown high MCP-1 levels during trichomonas infection [2], [3], [4], [5] in human prostate stromal myofibroblast cells (WPMY-1), HeLa cells, vaginal epithelial cells (VECs) but levels in response to symptomatic and asymptomatic isolates is not yet reported. In this article, we have reported MCP-1 levels in the vaginal washes and serum samples of BALB/c mouse infected with symptomatic and asymptomatic T. vaginalis isolates for different time points. We found higher levels of MCP-1 in vaginal washes of symptomatic group on 2nd day post infection (dpi) than control uninfected group. While on 4th dpi and 14th dpi, higher levels of MCP-1 in vaginal washes was observed in asymptomatic group as compared to control group. However, significant level of MCP-1 was observed in asymptomatic group on 14th dpi as compared to symptomatic group in vaginal washes. We have also observed significantly higher levels of MCP-1 in the serum samples of symptomatic group on 2nd, 4th and 14th dpi as compared to control group. A higher level of MCP-1 was found at all the time points in serum samples of asymptomatic group as compared to control group. Interestingly, a significant higher level of MCP-1 was found in the serum samples of BALB/c mice in asymptomatic as compared to symptomatic group. The MCP-1 levels in both vaginal washes and serum were significantly higher in asymptomatic group at later time points. SN - 2352-3409 UR - https://www.unboundmedicine.com/medline/citation/32395589/Data_showing_differential_expression_of_Monocyte_chemoattractant_protein-1_in_response_to_symptomatic_and_asymptomatic_T._vaginalis_infection L2 - https://linkinghub.elsevier.com/retrieve/pii/S2352-3409(20)30522-9 DB - PRIME DP - Unbound Medicine ER -
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