Tags

Type your tag names separated by a space and hit enter

Respiratory disease in rhesus macaques inoculated with SARS-CoV-2.
Nature. 2020 09; 585(7824):268-272.Nat

Abstract

An outbreak of coronavirus disease 2019 (COVID-19), which is caused by a novel coronavirus (named SARS-CoV-2) and has a case fatality rate of approximately 2%, started in Wuhan (China) in December 20191,2. Following an unprecedented global spread3, the World Health Organization declared COVID-19 a pandemic on 11 March 2020. Although data on COVID-19 in humans are emerging at a steady pace, some aspects of the pathogenesis of SARS-CoV-2 can be studied in detail only in animal models, in which repeated sampling and tissue collection is possible. Here we show that SARS-CoV-2 causes a respiratory disease in rhesus macaques that lasts between 8 and 16 days. Pulmonary infiltrates, which are a hallmark of COVID-19 in humans, were visible in lung radiographs. We detected high viral loads in swabs from the nose and throat of all of the macaques, as well as in bronchoalveolar lavages; in one macaque, we observed prolonged rectal shedding. Together, the rhesus macaque recapitulates the moderate disease that has been observed in the majority of human cases of COVID-19. The establishment of the rhesus macaque as a model of COVID-19 will increase our understanding of the pathogenesis of this disease, and aid in the development and testing of medical countermeasures.

Authors+Show Affiliations

Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.Rocky Mountain Veterinary Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.Rocky Mountain Veterinary Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.Rocky Mountain Veterinary Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.Rocky Mountain Veterinary Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.Rocky Mountain Veterinary Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA. emmie.dewit@nih.gov.

Pub Type(s)

Journal Article
Research Support, N.I.H., Intramural

Language

eng

PubMed ID

32396922

Citation

Munster, Vincent J., et al. "Respiratory Disease in Rhesus Macaques Inoculated With SARS-CoV-2." Nature, vol. 585, no. 7824, 2020, pp. 268-272.
Munster VJ, Feldmann F, Williamson BN, et al. Respiratory disease in rhesus macaques inoculated with SARS-CoV-2. Nature. 2020;585(7824):268-272.
Munster, V. J., Feldmann, F., Williamson, B. N., van Doremalen, N., Pérez-Pérez, L., Schulz, J., Meade-White, K., Okumura, A., Callison, J., Brumbaugh, B., Avanzato, V. A., Rosenke, R., Hanley, P. W., Saturday, G., Scott, D., Fischer, E. R., & de Wit, E. (2020). Respiratory disease in rhesus macaques inoculated with SARS-CoV-2. Nature, 585(7824), 268-272. https://doi.org/10.1038/s41586-020-2324-7
Munster VJ, et al. Respiratory Disease in Rhesus Macaques Inoculated With SARS-CoV-2. Nature. 2020;585(7824):268-272. PubMed PMID: 32396922.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Respiratory disease in rhesus macaques inoculated with SARS-CoV-2. AU - Munster,Vincent J, AU - Feldmann,Friederike, AU - Williamson,Brandi N, AU - van Doremalen,Neeltje, AU - Pérez-Pérez,Lizzette, AU - Schulz,Jonathan, AU - Meade-White,Kimberly, AU - Okumura,Atsushi, AU - Callison,Julie, AU - Brumbaugh,Beniah, AU - Avanzato,Victoria A, AU - Rosenke,Rebecca, AU - Hanley,Patrick W, AU - Saturday,Greg, AU - Scott,Dana, AU - Fischer,Elizabeth R, AU - de Wit,Emmie, Y1 - 2020/05/12/ PY - 2020/03/22/received PY - 2020/05/01/accepted PY - 2020/5/13/pubmed PY - 2020/9/17/medline PY - 2020/5/13/entrez SP - 268 EP - 272 JF - Nature JO - Nature VL - 585 IS - 7824 N2 - An outbreak of coronavirus disease 2019 (COVID-19), which is caused by a novel coronavirus (named SARS-CoV-2) and has a case fatality rate of approximately 2%, started in Wuhan (China) in December 20191,2. Following an unprecedented global spread3, the World Health Organization declared COVID-19 a pandemic on 11 March 2020. Although data on COVID-19 in humans are emerging at a steady pace, some aspects of the pathogenesis of SARS-CoV-2 can be studied in detail only in animal models, in which repeated sampling and tissue collection is possible. Here we show that SARS-CoV-2 causes a respiratory disease in rhesus macaques that lasts between 8 and 16 days. Pulmonary infiltrates, which are a hallmark of COVID-19 in humans, were visible in lung radiographs. We detected high viral loads in swabs from the nose and throat of all of the macaques, as well as in bronchoalveolar lavages; in one macaque, we observed prolonged rectal shedding. Together, the rhesus macaque recapitulates the moderate disease that has been observed in the majority of human cases of COVID-19. The establishment of the rhesus macaque as a model of COVID-19 will increase our understanding of the pathogenesis of this disease, and aid in the development and testing of medical countermeasures. SN - 1476-4687 UR - https://www.unboundmedicine.com/medline/citation/32396922/Respiratory_disease_in_rhesus_macaques_inoculated_with_SARS_CoV_2_ L2 - https://doi.org/10.1038/s41586-020-2324-7 DB - PRIME DP - Unbound Medicine ER -