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Platelet functions and activities as potential hematologic parameters related to Coronavirus Disease 2019 (Covid-19).
Platelets. 2020 Jul 03; 31(5):627-632.P

Abstract

Coronavirus disease 2019 (COVID-19) is a new infectious disease that currently lacks standardized and established laboratory markers to evaluate its severity. In COVID-19 patients, the number of platelets (PLTs) and dynamic changes of PLT-related parameters are currently a concern. The present paper discusses the potential link between PLT parameters and COVID-19. Several studies have identified a link between severe COVID-19 patients and specific coagulation index, in particular, high D-dimer level, prolonged prothrombin time, and low PLT count. These alterations reflect the hypercoagulable state present in severe COVID-19 patients, which could promote microthrombosis in the lungs, as well as in other organs. Further information and more advanced hematological parameters related to PLTs are needed to better estimate this link, also considering COVID-19 patients at different disease stages and stratified in different cohorts based on preexisting co-morbidity, age, and gender. Increasing the understanding of PLT functions in COVID-19 will undoubtedly improve our knowledge on disease pathogenesis, clinical management, and therapeutic options, but could also lead to the development of more precise therapeutic strategies for COVID-19 patients.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Salamanna F
Laboratory of Preclinical and Surgical Studies, IRCCS Istituto Ortopedico Rizzoli , Bologna, Italy.
Maglio M
Laboratory of Preclinical and Surgical Studies, IRCCS Istituto Ortopedico Rizzoli , Bologna, Italy.
Landini MP
Scientific Direction, IRCCS Istituto Ortopedico Rizzoli , Bologna, Italy.
Fini M
Laboratory of Preclinical and Surgical Studies, IRCCS Istituto Ortopedico Rizzoli , Bologna, Italy.

MeSH

Angiotensin-Converting Enzyme 2AnticoagulantsBetacoronavirusBiomarkersBlood PlateletsCOVID-19Cell Adhesion MoleculesCoronavirus InfectionsCytokinesDisseminated Intravascular CoagulationDrug InteractionsEndothelial CellsEndothelium, VascularFibrin Fibrinogen Degradation ProductsHumansInflammationLungPandemicsPeptidyl-Dipeptidase APlatelet CountPlatelet Function TestsPneumonia, ViralProthrombin TimeReceptors, VirusRespiratory Distress SyndromeSARS-CoV-2Severe Acute Respiratory SyndromeThrombophiliaVenous Thrombosis

Pub Type(s)

Comparative Study
Journal Article
Review

Language

eng

PubMed ID

32397915

Citation

Salamanna, Francesca, et al. "Platelet Functions and Activities as Potential Hematologic Parameters Related to Coronavirus Disease 2019 (Covid-19)." Platelets, vol. 31, no. 5, 2020, pp. 627-632.
Salamanna F, Maglio M, Landini MP, et al. Platelet functions and activities as potential hematologic parameters related to Coronavirus Disease 2019 (Covid-19). Platelets. 2020;31(5):627-632.
Salamanna, F., Maglio, M., Landini, M. P., & Fini, M. (2020). Platelet functions and activities as potential hematologic parameters related to Coronavirus Disease 2019 (Covid-19). Platelets, 31(5), 627-632. https://doi.org/10.1080/09537104.2020.1762852
Salamanna F, et al. Platelet Functions and Activities as Potential Hematologic Parameters Related to Coronavirus Disease 2019 (Covid-19). Platelets. 2020 Jul 3;31(5):627-632. PubMed PMID: 32397915.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Platelet functions and activities as potential hematologic parameters related to Coronavirus Disease 2019 (Covid-19). AU - Salamanna,Francesca, AU - Maglio,Melania, AU - Landini,Maria Paola, AU - Fini,Milena, Y1 - 2020/05/13/ PY - 2020/5/14/pubmed PY - 2020/7/14/medline PY - 2020/5/14/entrez KW - COVID-19 KW - hematological parameters KW - platelets SP - 627 EP - 632 JF - Platelets JO - Platelets VL - 31 IS - 5 N2 - Coronavirus disease 2019 (COVID-19) is a new infectious disease that currently lacks standardized and established laboratory markers to evaluate its severity. In COVID-19 patients, the number of platelets (PLTs) and dynamic changes of PLT-related parameters are currently a concern. The present paper discusses the potential link between PLT parameters and COVID-19. Several studies have identified a link between severe COVID-19 patients and specific coagulation index, in particular, high D-dimer level, prolonged prothrombin time, and low PLT count. These alterations reflect the hypercoagulable state present in severe COVID-19 patients, which could promote microthrombosis in the lungs, as well as in other organs. Further information and more advanced hematological parameters related to PLTs are needed to better estimate this link, also considering COVID-19 patients at different disease stages and stratified in different cohorts based on preexisting co-morbidity, age, and gender. Increasing the understanding of PLT functions in COVID-19 will undoubtedly improve our knowledge on disease pathogenesis, clinical management, and therapeutic options, but could also lead to the development of more precise therapeutic strategies for COVID-19 patients. SN - 1369-1635 UR - https://www.unboundmedicine.com/medline/citation/32397915/Platelet_functions_and_activities_as_potential_hematologic_parameters_related_to_Coronavirus_Disease_2019__Covid_19__ DB - PRIME DP - Unbound Medicine ER -