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COVID-19 vulnerability: the potential impact of genetic susceptibility and airborne transmission.
Hum Genomics. 2020 05 12; 14(1):17.HG

Abstract

The recent coronavirus disease (COVID-19), caused by SARS-CoV-2, is inarguably the most challenging coronavirus outbreak relative to the previous outbreaks involving SARS-CoV and MERS-CoV. With the number of COVID-19 cases now exceeding 2 million worldwide, it is apparent that (i) transmission of SARS-CoV-2 is very high and (ii) there are large variations in disease severity, one component of which may be genetic variability in the response to the virus. Controlling current rates of infection and combating future waves require a better understanding of the routes of exposure to SARS-CoV-2 and the underlying genomic susceptibility to this disease. In this mini-review, we highlight possible genetic determinants of COVID-19 and the contribution of aerosol exposure as a potentially important transmission route of SARS-CoV-2.

Authors+Show Affiliations

Department of Environmental Health Sciences, School of Public Health, Yale University, New Haven, CT, 06510, USA. krystal.pollitt@yale.edu.Department of Chemical & Environmental Engineering, School of Engineering & Applied Science, Yale University, New Haven, CT, 06520, USA.Department of Epidemiology of Microbial Diseases, School of Public Health, Yale University, New Haven, CT, 06510, USA.Section of Pulmonary, Critical Care and Sleep Medicine, School of Medicine, Yale University, New Haven, CT, 06520, USA.Section of Pulmonary, Critical Care and Sleep Medicine, School of Medicine, Yale University, New Haven, CT, 06520, USA.Department of Environmental Health and Center for Environmental Genetics, University Cincinnati Medical Center, Cincinnati, OH, 45267, USA.Australian Institute of Tropical Health and Medicine, James Cook University, Smithfield, QLD, Australia.Department of Clinical Pharmacy, Skaggs School of Pharmacy & Pharmaceutical Sciences, University of Colorado Denver, Aurora, CO, 80045, USA.Department of Environmental Health Sciences, School of Public Health, Yale University, New Haven, CT, 06510, USA. vasilis.vasiliou@yale.edu.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32398162

Citation

Godri Pollitt, Krystal J., et al. "COVID-19 Vulnerability: the Potential Impact of Genetic Susceptibility and Airborne Transmission." Human Genomics, vol. 14, no. 1, 2020, p. 17.
Godri Pollitt KJ, Peccia J, Ko AI, et al. COVID-19 vulnerability: the potential impact of genetic susceptibility and airborne transmission. Hum Genomics. 2020;14(1):17.
Godri Pollitt, K. J., Peccia, J., Ko, A. I., Kaminski, N., Dela Cruz, C. S., Nebert, D. W., Reichardt, J. K. V., Thompson, D. C., & Vasiliou, V. (2020). COVID-19 vulnerability: the potential impact of genetic susceptibility and airborne transmission. Human Genomics, 14(1), 17. https://doi.org/10.1186/s40246-020-00267-3
Godri Pollitt KJ, et al. COVID-19 Vulnerability: the Potential Impact of Genetic Susceptibility and Airborne Transmission. Hum Genomics. 2020 05 12;14(1):17. PubMed PMID: 32398162.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - COVID-19 vulnerability: the potential impact of genetic susceptibility and airborne transmission. AU - Godri Pollitt,Krystal J, AU - Peccia,Jordan, AU - Ko,Albert I, AU - Kaminski,Naftali, AU - Dela Cruz,Charles S, AU - Nebert,Daniel W, AU - Reichardt,Juergen K V, AU - Thompson,David C, AU - Vasiliou,Vasilis, Y1 - 2020/05/12/ PY - 2020/04/20/received PY - 2020/04/29/accepted PY - 2020/5/14/entrez PY - 2020/5/14/pubmed PY - 2020/5/15/medline SP - 17 EP - 17 JF - Human genomics JO - Hum. Genomics VL - 14 IS - 1 N2 - The recent coronavirus disease (COVID-19), caused by SARS-CoV-2, is inarguably the most challenging coronavirus outbreak relative to the previous outbreaks involving SARS-CoV and MERS-CoV. With the number of COVID-19 cases now exceeding 2 million worldwide, it is apparent that (i) transmission of SARS-CoV-2 is very high and (ii) there are large variations in disease severity, one component of which may be genetic variability in the response to the virus. Controlling current rates of infection and combating future waves require a better understanding of the routes of exposure to SARS-CoV-2 and the underlying genomic susceptibility to this disease. In this mini-review, we highlight possible genetic determinants of COVID-19 and the contribution of aerosol exposure as a potentially important transmission route of SARS-CoV-2. SN - 1479-7364 UR - https://www.unboundmedicine.com/medline/citation/32398162/COVID_19_vulnerability:_the_potential_impact_of_genetic_susceptibility_and_airborne_transmission_ L2 - https://humgenomics.biomedcentral.com/articles/10.1186/s40246-020-00267-3 DB - PRIME DP - Unbound Medicine ER -