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Involvement of the Nervous System in SARS-CoV-2 Infection.
Neurotox Res. 2020 Jun; 38(1):1-7.NR

Abstract

As a severe and highly contagious infectious disease, coronavirus disease 2019 (COVID-19) has caused a global pandemic. Several case reports have demonstrated that the respiratory system is the main target in patients with COVID-19, but the disease is not limited to the respiratory system. Case analysis indicated that the nervous system can be invaded by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and that 36.4% of COVID-19 patients had neurological symptoms. Importantly, the involvement of the CNS may be associated with poor prognosis and disease worsening. Here, we discussed the symptoms and evidence of nervous system involvement (directly and indirectly) caused by SARS-CoV-2 infection and possible mechanisms. CNS symptoms could be a potential indicator of poor prognosis; therefore, the prevention and treatment of CNS symptoms are also crucial for the recovery of COVID-19 patients.

Authors+Show Affiliations

Department of Neurology, The First Affiliated Hospital of Soochow University, Suzhou, 215004, Jiangsu, China.Department of Neurology, The First Affiliated Hospital of Soochow University, Suzhou, 215004, Jiangsu, China. qxue_sz@163.com.Department of Neurology, The First Affiliated Hospital of Soochow University, Suzhou, 215004, Jiangsu, China. xingshunxu@suda.edu.cn. Institute of Neuroscience, Soochow University, Suzhou, 215123, Jiangsu, China. xingshunxu@suda.edu.cn. Jiangsu Key Laboratory of Neuropsychiatric Diseases, Soochow University, Suzhou, 215123, Jiangsu, China. xingshunxu@suda.edu.cn.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32399719

Citation

Li, Hao, et al. "Involvement of the Nervous System in SARS-CoV-2 Infection." Neurotoxicity Research, vol. 38, no. 1, 2020, pp. 1-7.
Li H, Xue Q, Xu X. Involvement of the Nervous System in SARS-CoV-2 Infection. Neurotox Res. 2020;38(1):1-7.
Li, H., Xue, Q., & Xu, X. (2020). Involvement of the Nervous System in SARS-CoV-2 Infection. Neurotoxicity Research, 38(1), 1-7. https://doi.org/10.1007/s12640-020-00219-8
Li H, Xue Q, Xu X. Involvement of the Nervous System in SARS-CoV-2 Infection. Neurotox Res. 2020;38(1):1-7. PubMed PMID: 32399719.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Involvement of the Nervous System in SARS-CoV-2 Infection. AU - Li,Hao, AU - Xue,Qun, AU - Xu,Xingshun, Y1 - 2020/05/13/ PY - 2020/04/07/received PY - 2020/04/24/accepted PY - 2020/04/22/revised PY - 2020/5/14/pubmed PY - 2020/5/30/medline PY - 2020/5/14/entrez KW - COVID-19 KW - Central nervous system KW - Infection KW - SARS-CoV-2 SP - 1 EP - 7 JF - Neurotoxicity research JO - Neurotox Res VL - 38 IS - 1 N2 - As a severe and highly contagious infectious disease, coronavirus disease 2019 (COVID-19) has caused a global pandemic. Several case reports have demonstrated that the respiratory system is the main target in patients with COVID-19, but the disease is not limited to the respiratory system. Case analysis indicated that the nervous system can be invaded by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and that 36.4% of COVID-19 patients had neurological symptoms. Importantly, the involvement of the CNS may be associated with poor prognosis and disease worsening. Here, we discussed the symptoms and evidence of nervous system involvement (directly and indirectly) caused by SARS-CoV-2 infection and possible mechanisms. CNS symptoms could be a potential indicator of poor prognosis; therefore, the prevention and treatment of CNS symptoms are also crucial for the recovery of COVID-19 patients. SN - 1476-3524 UR - https://www.unboundmedicine.com/medline/citation/32399719/full_citation L2 - https://dx.doi.org/10.1007/s12640-020-00219-8 DB - PRIME DP - Unbound Medicine ER -