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Sexually Transmitted Infection Prevalence Among Women at Risk for HIV Exposure Initiating Safer Conception Care in Rural, Southwestern Uganda.
Sex Transm Dis. 2020 Aug; 47(8):e24-e28.ST

Abstract

BACKGROUND

Knowledge of sexually transmitted infection (STI) prevalence and risk factors is important to the development of tenofovir-based preexposure prophylaxis (PrEP) and safer conception programming. We introduced STI screening among women at risk for HIV exposure who were participating in a safer conception study in southwestern Uganda.

METHODS

We enrolled 131 HIV-uninfected women, planning for pregnancy with a partner living with HIV or of unknown HIV serostatus (2018-2019). Women were offered comprehensive safer conception counseling, including PrEP. Participants completed interviewer-administered questionnaires detailing sociodemographics and sexual history. We integrated laboratory screening for chlamydia, gonorrhea, trichomoniasis, and syphilis as a substudy to assess STI prevalence. Multivariable logistic regression was used to determine correlates.

RESULTS

Ninety-four women completed STI screening (72% of enrolled). Median age was 30 (interquartile range, 26-34) years, and 94% chose PrEP as part of safer conception care. Overall, 24% had STIs: 13% chlamydia, 2% gonorrhea, 6% trichomoniasis, 6% syphilis, and 3% ≥2 STI. Sexually transmitted infection prevalence was associated with younger age (adjusted odds ratio [AOR], 0.87; 95% confidence interval [CI], 0.77-0.99), prior stillbirth (AOR, 5.04; 95% CI, 1.12-22.54), and not feeling vulnerable to HIV (AOR, 16.33; 95% CI, 1.12-237.94).

CONCLUSIONS

We describe a 24% curable STI prevalence among women at risk for HIV exposure who were planning for pregnancy. These data highlight the importance of integrating laboratory-based STI screening into safer conception programs to maximize the health of HIV-affected women, children, and families.

Authors+Show Affiliations

From the Division of Infectious Diseases, Massachusetts General Hospital. Division of Infectious Diseases and General Internal Medicine, Brigham and Women's Hospital, Boston, MA.Mbarara Regional Referral Hospital and Mbarara University of Science and Technology, Mbarara, Uganda. Massachusetts General Hospital, Mbarara University of Science and Technology Global Health Collaborative, Boston, MA, and Mbarara, Uganda.Massachusetts General Hospital, Mbarara University of Science and Technology Global Health Collaborative, Boston, MA, and Mbarara, Uganda.Massachusetts General Hospital, Mbarara University of Science and Technology Global Health Collaborative, Boston, MA, and Mbarara, Uganda.Mbarara Regional Referral Hospital and Mbarara University of Science and Technology, Mbarara, Uganda.Mbarara Regional Referral Hospital and Mbarara University of Science and Technology, Mbarara, Uganda.Massachusetts General Hospital, Mbarara University of Science and Technology Global Health Collaborative, Boston, MA, and Mbarara, Uganda.OHSU PSU School of Public Health, Portland, OR.Division of Infectious Diseases, University of Alabama at Birmingham, Birmingham, AL.Massachusetts General Hospital, Mbarara University of Science and Technology Global Health Collaborative, Boston, MA, and Mbarara, Uganda. Center for Global Health, Massachusetts General Hospital, Boston, MA.Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada.From the Division of Infectious Diseases, Massachusetts General Hospital. Division of Infectious Diseases, University of Alabama at Birmingham, Birmingham, AL.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32404858

Citation

Chitneni, Pooja, et al. "Sexually Transmitted Infection Prevalence Among Women at Risk for HIV Exposure Initiating Safer Conception Care in Rural, Southwestern Uganda." Sexually Transmitted Diseases, vol. 47, no. 8, 2020, pp. e24-e28.
Chitneni P, Bwana MB, Owembabazi M, et al. Sexually Transmitted Infection Prevalence Among Women at Risk for HIV Exposure Initiating Safer Conception Care in Rural, Southwestern Uganda. Sex Transm Dis. 2020;47(8):e24-e28.
Chitneni, P., Bwana, M. B., Owembabazi, M., OʼNeil, K., Kalyebara, P. K., Muyindike, W., Musinguzi, N., Bangsberg, D. R., Marrazzo, J. M., Haberer, J. E., Kaida, A., & Matthews, L. T. (2020). Sexually Transmitted Infection Prevalence Among Women at Risk for HIV Exposure Initiating Safer Conception Care in Rural, Southwestern Uganda. Sexually Transmitted Diseases, 47(8), e24-e28. https://doi.org/10.1097/OLQ.0000000000001197
Chitneni P, et al. Sexually Transmitted Infection Prevalence Among Women at Risk for HIV Exposure Initiating Safer Conception Care in Rural, Southwestern Uganda. Sex Transm Dis. 2020;47(8):e24-e28. PubMed PMID: 32404858.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sexually Transmitted Infection Prevalence Among Women at Risk for HIV Exposure Initiating Safer Conception Care in Rural, Southwestern Uganda. AU - Chitneni,Pooja, AU - Bwana,Mwebesa Bosco, AU - Owembabazi,Moran, AU - OʼNeil,Kasey, AU - Kalyebara,Paul Kato, AU - Muyindike,Winnie, AU - Musinguzi,Nicholas, AU - Bangsberg,David R, AU - Marrazzo,Jeanne M, AU - Haberer,Jessica E, AU - Kaida,Angela, AU - Matthews,Lynn T, PY - 2021/08/01/pmc-release PY - 2020/5/15/pubmed PY - 2020/5/15/medline PY - 2020/5/15/entrez SP - e24 EP - e28 JF - Sexually transmitted diseases JO - Sex Transm Dis VL - 47 IS - 8 N2 - BACKGROUND: Knowledge of sexually transmitted infection (STI) prevalence and risk factors is important to the development of tenofovir-based preexposure prophylaxis (PrEP) and safer conception programming. We introduced STI screening among women at risk for HIV exposure who were participating in a safer conception study in southwestern Uganda. METHODS: We enrolled 131 HIV-uninfected women, planning for pregnancy with a partner living with HIV or of unknown HIV serostatus (2018-2019). Women were offered comprehensive safer conception counseling, including PrEP. Participants completed interviewer-administered questionnaires detailing sociodemographics and sexual history. We integrated laboratory screening for chlamydia, gonorrhea, trichomoniasis, and syphilis as a substudy to assess STI prevalence. Multivariable logistic regression was used to determine correlates. RESULTS: Ninety-four women completed STI screening (72% of enrolled). Median age was 30 (interquartile range, 26-34) years, and 94% chose PrEP as part of safer conception care. Overall, 24% had STIs: 13% chlamydia, 2% gonorrhea, 6% trichomoniasis, 6% syphilis, and 3% ≥2 STI. Sexually transmitted infection prevalence was associated with younger age (adjusted odds ratio [AOR], 0.87; 95% confidence interval [CI], 0.77-0.99), prior stillbirth (AOR, 5.04; 95% CI, 1.12-22.54), and not feeling vulnerable to HIV (AOR, 16.33; 95% CI, 1.12-237.94). CONCLUSIONS: We describe a 24% curable STI prevalence among women at risk for HIV exposure who were planning for pregnancy. These data highlight the importance of integrating laboratory-based STI screening into safer conception programs to maximize the health of HIV-affected women, children, and families. SN - 1537-4521 UR - https://www.unboundmedicine.com/medline/citation/32404858/STI_prevalence_among_women_at_risk_for_HIV_exposure_initiating_safer_conception_care_in_rural,_southwestern_Uganda L2 - https://doi.org/10.1097/OLQ.0000000000001197 DB - PRIME DP - Unbound Medicine ER -
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