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Decreased T cell populations contribute to the increased severity of COVID-19.
Clin Chim Acta. 2020 Sep; 508:110-114.CC

Abstract

BACKGROUND

We observe changes of the main lymphocyte subsets (CD16+CD56、CD19、CD3、CD4、and CD8) in COVID-19-infected patients and explore whether the changes are associated with disease severity.

METHODS

One-hundred and fifty-four cases of COVID-19-infected patients were selected and divided into 3 groups (moderate group, severe group and critical group). The flow cytometry assay was performed to examine the numbers of lymphocyte subsets.

RESULTS

CD3+, CD4+ and CD8 + T lymphocyte subsets were decreased in COVID-19-infected patients. Compared with the moderate group and the sever group, CD3+, CD4+ and CD8+ T cells in the critical group decreased greatly (P < 0.001, P = 0.005 or P = 0.001).

CONCLUSIONS

Reduced CD3+, CD4+, CD8+ T lymphocyte counts may reflect the severity of the COVID-19. Monitoring T cell changes has important implications for the diagnosis and treatment of severe patients who may become critically ill.

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Authors+Show Affiliations

Liu R
Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, PR China.
Wang Y
Shanghai Health Commission Key Lab of Artificial Intelligence (AI)-Based Management of Inflammation and Chronic Diseases, Sino-French Cooperative Central Lab, Shanghai Pudong Gongli Hospital, Secondary Military Medical University, Shanghai 200135, PR China.
Li J
Postgraduate training base in Shanghai Gongli Hospital, Ningxia medical university, Pudong New Area, Shanghai200135, PR China.
Han H
Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, PR China.
Xia Z
Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, PR China.
Liu F
State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, PR China; Wuhan Institute of Biotechnology, Wuhan, Hubei 430075, PR China.
Wu K
State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, PR China.
Yang L
Department of Clinical Laboratory, Shanghai Gongli Hospital, the Second Military Medical University, Pudong New Area, Shanghai200135, PR China.
Liu X
Department of Clinical Laboratory, Shanghai Gongli Hospital, the Second Military Medical University, Pudong New Area, Shanghai200135, PR China.
Zhu C
Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, PR China. Electronic address: xinchengzhu@163.com.

MeSH

AgedAged, 80 and overBetacoronavirusBiomarkersCD3 ComplexCD4 AntigensCD8 AntigensCOVID-19Cardiovascular DiseasesCohort StudiesComorbidityCoronavirus InfectionsDiabetes MellitusFemaleGene ExpressionHumansImmunophenotypingLung DiseasesMaleMiddle AgedPandemicsPatient SelectionPneumonia, ViralPrognosisSARS-CoV-2Severity of Illness IndexSurvival AnalysisT-Lymphocyte Subsets

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32405080

Citation

Liu, Rui, et al. "Decreased T Cell Populations Contribute to the Increased Severity of COVID-19." Clinica Chimica Acta; International Journal of Clinical Chemistry, vol. 508, 2020, pp. 110-114.
Liu R, Wang Y, Li J, et al. Decreased T cell populations contribute to the increased severity of COVID-19. Clin Chim Acta. 2020;508:110-114.
Liu, R., Wang, Y., Li, J., Han, H., Xia, Z., Liu, F., Wu, K., Yang, L., Liu, X., & Zhu, C. (2020). Decreased T cell populations contribute to the increased severity of COVID-19. Clinica Chimica Acta; International Journal of Clinical Chemistry, 508, 110-114. https://doi.org/10.1016/j.cca.2020.05.019
Liu R, et al. Decreased T Cell Populations Contribute to the Increased Severity of COVID-19. Clin Chim Acta. 2020;508:110-114. PubMed PMID: 32405080.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Decreased T cell populations contribute to the increased severity of COVID-19. AU - Liu,Rui, AU - Wang,Ying, AU - Li,Jie, AU - Han,Huan, AU - Xia,Zunen, AU - Liu,Fang, AU - Wu,Kailang, AU - Yang,Lan, AU - Liu,Xinghui, AU - Zhu,Chengliang, Y1 - 2020/05/13/ PY - 2020/03/24/received PY - 2020/05/06/revised PY - 2020/05/08/accepted PY - 2020/5/15/pubmed PY - 2020/7/23/medline PY - 2020/5/15/entrez KW - CD3(+) T cells KW - CD4(+) T cells KW - CD8(+) T cells KW - COVID-19 KW - Lymphocyte subsets SP - 110 EP - 114 JF - Clinica chimica acta; international journal of clinical chemistry JO - Clin Chim Acta VL - 508 N2 - BACKGROUND: We observe changes of the main lymphocyte subsets (CD16+CD56、CD19、CD3、CD4、and CD8) in COVID-19-infected patients and explore whether the changes are associated with disease severity. METHODS: One-hundred and fifty-four cases of COVID-19-infected patients were selected and divided into 3 groups (moderate group, severe group and critical group). The flow cytometry assay was performed to examine the numbers of lymphocyte subsets. RESULTS: CD3+, CD4+ and CD8 + T lymphocyte subsets were decreased in COVID-19-infected patients. Compared with the moderate group and the sever group, CD3+, CD4+ and CD8+ T cells in the critical group decreased greatly (P < 0.001, P = 0.005 or P = 0.001). CONCLUSIONS: Reduced CD3+, CD4+, CD8+ T lymphocyte counts may reflect the severity of the COVID-19. Monitoring T cell changes has important implications for the diagnosis and treatment of severe patients who may become critically ill. SN - 1873-3492 UR - https://www.unboundmedicine.com/medline/citation/32405080/Decreased_T_cell_populations_contribute_to_the_increased_severity_of_COVID_19_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0009-8981(20)30216-3 DB - PRIME DP - Unbound Medicine ER -