Citation
Liu, Rui, et al. "Decreased T Cell Populations Contribute to the Increased Severity of COVID-19." Clinica Chimica Acta; International Journal of Clinical Chemistry, vol. 508, 2020, pp. 110-114.
Liu R, Wang Y, Li J, et al. Decreased T cell populations contribute to the increased severity of COVID-19. Clin Chim Acta. 2020;508:110-114.
Liu, R., Wang, Y., Li, J., Han, H., Xia, Z., Liu, F., Wu, K., Yang, L., Liu, X., & Zhu, C. (2020). Decreased T cell populations contribute to the increased severity of COVID-19. Clinica Chimica Acta; International Journal of Clinical Chemistry, 508, 110-114. https://doi.org/10.1016/j.cca.2020.05.019
Liu R, et al. Decreased T Cell Populations Contribute to the Increased Severity of COVID-19. Clin Chim Acta. 2020;508:110-114. PubMed PMID: 32405080.
TY - JOUR
T1 - Decreased T cell populations contribute to the increased severity of COVID-19.
AU - Liu,Rui,
AU - Wang,Ying,
AU - Li,Jie,
AU - Han,Huan,
AU - Xia,Zunen,
AU - Liu,Fang,
AU - Wu,Kailang,
AU - Yang,Lan,
AU - Liu,Xinghui,
AU - Zhu,Chengliang,
Y1 - 2020/05/13/
PY - 2020/03/24/received
PY - 2020/05/06/revised
PY - 2020/05/08/accepted
PY - 2020/5/15/pubmed
PY - 2020/7/23/medline
PY - 2020/5/15/entrez
KW - CD3(+) T cells
KW - CD4(+) T cells
KW - CD8(+) T cells
KW - COVID-19
KW - Lymphocyte subsets
SP - 110
EP - 114
JF - Clinica chimica acta; international journal of clinical chemistry
JO - Clin Chim Acta
VL - 508
N2 - BACKGROUND: We observe changes of the main lymphocyte subsets (CD16+CD56、CD19、CD3、CD4、and CD8) in COVID-19-infected patients and explore whether the changes are associated with disease severity. METHODS: One-hundred and fifty-four cases of COVID-19-infected patients were selected and divided into 3 groups (moderate group, severe group and critical group). The flow cytometry assay was performed to examine the numbers of lymphocyte subsets. RESULTS: CD3+, CD4+ and CD8 + T lymphocyte subsets were decreased in COVID-19-infected patients. Compared with the moderate group and the sever group, CD3+, CD4+ and CD8+ T cells in the critical group decreased greatly (P < 0.001, P = 0.005 or P = 0.001). CONCLUSIONS: Reduced CD3+, CD4+, CD8+ T lymphocyte counts may reflect the severity of the COVID-19. Monitoring T cell changes has important implications for the diagnosis and treatment of severe patients who may become critically ill.
SN - 1873-3492
UR - https://www.unboundmedicine.com/medline/citation/32405080/Decreased_T_cell_populations_contribute_to_the_increased_severity_of_COVID_19_
L2 - https://linkinghub.elsevier.com/retrieve/pii/S0009-8981(20)30216-3
DB - PRIME
DP - Unbound Medicine
ER -