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Decreased T cell populations contribute to the increased severity of COVID-19.
Clin Chim Acta. 2020 Sep; 508:110-114.CC

Abstract

BACKGROUND

We observe changes of the main lymphocyte subsets (CD16+CD56、CD19、CD3、CD4、and CD8) in COVID-19-infected patients and explore whether the changes are associated with disease severity.

METHODS

One-hundred and fifty-four cases of COVID-19-infected patients were selected and divided into 3 groups (moderate group, severe group and critical group). The flow cytometry assay was performed to examine the numbers of lymphocyte subsets.

RESULTS

CD3+, CD4+ and CD8 + T lymphocyte subsets were decreased in COVID-19-infected patients. Compared with the moderate group and the sever group, CD3+, CD4+ and CD8+ T cells in the critical group decreased greatly (P < 0.001, P = 0.005 or P = 0.001).

CONCLUSIONS

Reduced CD3+, CD4+, CD8+ T lymphocyte counts may reflect the severity of the COVID-19. Monitoring T cell changes has important implications for the diagnosis and treatment of severe patients who may become critically ill.

Authors+Show Affiliations

Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, PR China.Shanghai Health Commission Key Lab of Artificial Intelligence (AI)-Based Management of Inflammation and Chronic Diseases, Sino-French Cooperative Central Lab, Shanghai Pudong Gongli Hospital, Secondary Military Medical University, Shanghai 200135, PR China.Postgraduate training base in Shanghai Gongli Hospital, Ningxia medical university, Pudong New Area, Shanghai200135, PR China.Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, PR China.Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, PR China.State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, PR China; Wuhan Institute of Biotechnology, Wuhan, Hubei 430075, PR China.State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, PR China.Department of Clinical Laboratory, Shanghai Gongli Hospital, the Second Military Medical University, Pudong New Area, Shanghai200135, PR China.Department of Clinical Laboratory, Shanghai Gongli Hospital, the Second Military Medical University, Pudong New Area, Shanghai200135, PR China.Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, PR China. Electronic address: xinchengzhu@163.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32405080

Citation

Liu, Rui, et al. "Decreased T Cell Populations Contribute to the Increased Severity of COVID-19." Clinica Chimica Acta; International Journal of Clinical Chemistry, vol. 508, 2020, pp. 110-114.
Liu R, Wang Y, Li J, et al. Decreased T cell populations contribute to the increased severity of COVID-19. Clin Chim Acta. 2020;508:110-114.
Liu, R., Wang, Y., Li, J., Han, H., Xia, Z., Liu, F., Wu, K., Yang, L., Liu, X., & Zhu, C. (2020). Decreased T cell populations contribute to the increased severity of COVID-19. Clinica Chimica Acta; International Journal of Clinical Chemistry, 508, 110-114. https://doi.org/10.1016/j.cca.2020.05.019
Liu R, et al. Decreased T Cell Populations Contribute to the Increased Severity of COVID-19. Clin Chim Acta. 2020;508:110-114. PubMed PMID: 32405080.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Decreased T cell populations contribute to the increased severity of COVID-19. AU - Liu,Rui, AU - Wang,Ying, AU - Li,Jie, AU - Han,Huan, AU - Xia,Zunen, AU - Liu,Fang, AU - Wu,Kailang, AU - Yang,Lan, AU - Liu,Xinghui, AU - Zhu,Chengliang, Y1 - 2020/05/13/ PY - 2020/03/24/received PY - 2020/05/06/revised PY - 2020/05/08/accepted PY - 2020/5/15/pubmed PY - 2020/7/23/medline PY - 2020/5/15/entrez KW - CD3(+) T cells KW - CD4(+) T cells KW - CD8(+) T cells KW - COVID-19 KW - Lymphocyte subsets SP - 110 EP - 114 JF - Clinica chimica acta; international journal of clinical chemistry JO - Clin. Chim. Acta VL - 508 N2 - BACKGROUND: We observe changes of the main lymphocyte subsets (CD16+CD56、CD19、CD3、CD4、and CD8) in COVID-19-infected patients and explore whether the changes are associated with disease severity. METHODS: One-hundred and fifty-four cases of COVID-19-infected patients were selected and divided into 3 groups (moderate group, severe group and critical group). The flow cytometry assay was performed to examine the numbers of lymphocyte subsets. RESULTS: CD3+, CD4+ and CD8 + T lymphocyte subsets were decreased in COVID-19-infected patients. Compared with the moderate group and the sever group, CD3+, CD4+ and CD8+ T cells in the critical group decreased greatly (P < 0.001, P = 0.005 or P = 0.001). CONCLUSIONS: Reduced CD3+, CD4+, CD8+ T lymphocyte counts may reflect the severity of the COVID-19. Monitoring T cell changes has important implications for the diagnosis and treatment of severe patients who may become critically ill. SN - 1873-3492 UR - https://www.unboundmedicine.com/medline/citation/32405080/Decreased_T_cell_populations_contribute_to_the_increased_severity_of_COVID_19_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0009-8981(20)30216-3 DB - PRIME DP - Unbound Medicine ER -