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Effect of gallic acid on electrophysiological properties and ventricular arrhythmia following chemical-induced arrhythmia in rat.
Iran J Basic Med Sci. 2020 Feb; 23(2):167-172.IJ

Abstract

Objectives

Ventricular arrhythmias including ventricular tachycardia (VT) and ventricular fibrillation (VF) are the most important causes of mortality rate. Gallic acid (GA) has beneficial effects on cardiovascular diseases. The aim of this study was to evaluate the effects of GA on electrophysiological parameters such as QRS complex, heart rate (HR), PR interval parameters, and ventricular arrhythmia following chemical induction in rat.

Materials and Methods

Seventy-two male rats were divided into 9 groups (n=8). Chronic groups pretreated by GA (10, 30, and 50 mg/kg, orally) and normal saline (N/S, 1 ml/kg, orally) for 10 days. At the start of the experiments (the first day) and on the final day of the experiments (tenth day), the electrocardiogram (lead II) was recorded. At acute group, GA (50 mg/kg), and anti-arrhythmic drugs such as propranolol, amiodarone, and verapamil injected via intravenous (IV). Then, arrhythmia induced by a CaCl2 2.5% solution (140 mg/kg, IV). Afterward, percentage of premature ventricular beats (PVB), VF, and VT were recorded at 1, and 3 min.

Results

These findings showed that chronic and acute doses of GA have positive inotropic and anti-dysrhythmic effects by significant reduction of PVB, VT and VF on comparison with the control group. These actions are comparable to anti-arrhythmic drugs such as quinidine, propranolol, amiodarone, and verapamil. GA has not significant effect on chronotropic and dromotropic properties.

Conclusion

Findings showed that GA has antiarrhythmic, and inotropic characteristics that suggested GA has effective for mild congestive heart failure, and cardiovascular disorders patients which susceptible to incidence of arrhythmias.

Authors+Show Affiliations

Department of Physiology, Persian Gulf Physiology Research Center, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.Department of Physiology, Persian Gulf Physiology Research Center, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.Department of Physiology, Persian Gulf Physiology Research Center, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32405358

Citation

Akbari, Ghaidafeh, et al. "Effect of Gallic Acid On Electrophysiological Properties and Ventricular Arrhythmia Following Chemical-induced Arrhythmia in Rat." Iranian Journal of Basic Medical Sciences, vol. 23, no. 2, 2020, pp. 167-172.
Akbari G, Dianat M, Badavi M. Effect of gallic acid on electrophysiological properties and ventricular arrhythmia following chemical-induced arrhythmia in rat. Iran J Basic Med Sci. 2020;23(2):167-172.
Akbari, G., Dianat, M., & Badavi, M. (2020). Effect of gallic acid on electrophysiological properties and ventricular arrhythmia following chemical-induced arrhythmia in rat. Iranian Journal of Basic Medical Sciences, 23(2), 167-172. https://doi.org/10.22038/IJBMS.2019.33296.7948
Akbari G, Dianat M, Badavi M. Effect of Gallic Acid On Electrophysiological Properties and Ventricular Arrhythmia Following Chemical-induced Arrhythmia in Rat. Iran J Basic Med Sci. 2020;23(2):167-172. PubMed PMID: 32405358.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of gallic acid on electrophysiological properties and ventricular arrhythmia following chemical-induced arrhythmia in rat. AU - Akbari,Ghaidafeh, AU - Dianat,Mahin, AU - Badavi,Mohammad, PY - 2020/5/15/entrez PY - 2020/5/15/pubmed PY - 2020/5/15/medline KW - Arrhythmia KW - Electrophysiological – properties KW - Gallic acid KW - Rat KW - Ventricular SP - 167 EP - 172 JF - Iranian journal of basic medical sciences JO - Iran J Basic Med Sci VL - 23 IS - 2 N2 - Objectives: Ventricular arrhythmias including ventricular tachycardia (VT) and ventricular fibrillation (VF) are the most important causes of mortality rate. Gallic acid (GA) has beneficial effects on cardiovascular diseases. The aim of this study was to evaluate the effects of GA on electrophysiological parameters such as QRS complex, heart rate (HR), PR interval parameters, and ventricular arrhythmia following chemical induction in rat. Materials and Methods: Seventy-two male rats were divided into 9 groups (n=8). Chronic groups pretreated by GA (10, 30, and 50 mg/kg, orally) and normal saline (N/S, 1 ml/kg, orally) for 10 days. At the start of the experiments (the first day) and on the final day of the experiments (tenth day), the electrocardiogram (lead II) was recorded. At acute group, GA (50 mg/kg), and anti-arrhythmic drugs such as propranolol, amiodarone, and verapamil injected via intravenous (IV). Then, arrhythmia induced by a CaCl2 2.5% solution (140 mg/kg, IV). Afterward, percentage of premature ventricular beats (PVB), VF, and VT were recorded at 1, and 3 min. Results: These findings showed that chronic and acute doses of GA have positive inotropic and anti-dysrhythmic effects by significant reduction of PVB, VT and VF on comparison with the control group. These actions are comparable to anti-arrhythmic drugs such as quinidine, propranolol, amiodarone, and verapamil. GA has not significant effect on chronotropic and dromotropic properties. Conclusion: Findings showed that GA has antiarrhythmic, and inotropic characteristics that suggested GA has effective for mild congestive heart failure, and cardiovascular disorders patients which susceptible to incidence of arrhythmias. SN - 2008-3866 UR - https://www.unboundmedicine.com/medline/citation/32405358/Effect_of_gallic_acid_on_electrophysiological_properties_and_ventricular_arrhythmia_following_chemical-induced_arrhythmia_in_rat L2 - https://antibodies.cancer.gov/detail/CPTC-PGR-2 DB - PRIME DP - Unbound Medicine ER -
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