Tags

Type your tag names separated by a space and hit enter

Trichomoniasis in a tertiary hospital of Madrid, Spain (2013-2017): prevalence and pregnancy rate, coinfections, metronidazole resistance, and endosymbiosis.
Parasitol Res. 2020 Jun; 119(6):1915-1923.PR

Abstract

Trichomoniasis is the most prevalent curable sexually transmitted infection (STI) worldwide and a risk factor for the acquisition of other STIs and adverse pregnancy outcomes. The objectives of this study were to determine the prevalence of T. vaginalis and related coinfections in women attending a third-level hospital of Madrid (Spain). A retrospective study of 24,173 vaginal exudates from women with suspected vaginitis was conducted between 2013 and 2017. Likewise, among T. vaginalis positive samples, co-occurrence with gonorrhea, chlamydia, syphilis, VIH, Mycoplasma hominis, and Ureaplasma urealyticum was checked. Moreover, seven T. vaginalis isolates from 2017 were randomly collected for endobionts, drug resistance, and microsatellite (MS) instability determinations. The prevalence of T. vaginalis was 0.8% between 2013 and 2017. Less than 20% of patients with trichomoniasis were submitted to a complete screening for other genital pathogens. From that, two patients were coinfected with chlamydia and three with syphilis. Surprisingly, 6.4% of positive samples were diagnosed among pregnant women, showing an alarming increase from 3.2% (2014) to 10% (2017). Among the isolates randomly analyzed, five carried T. vaginalis virus, five harbored mycoplasmas, and one was metronidazole-resistant. The molecular genotyping showed a high variability in the three MS evaluated. To our knowledge, this is the first study in Spain that evaluates the prevalence of trichomoniasis in general and pregnant population and includes biomolecular determinations. These results warn about the increasing prevalence and highlight the importance of including T. vaginalis detection in routine gynecological revisions with special emphasis on childbearing age women and patients with previous STIs.

Authors+Show Affiliations

Departamento de Microbiología y Parasitología, Facultad de Farmacia, Universidad Complutense de Madrid, Madrid, Spain.Servicio de Microbiología y Parasitología Clínica, Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain.Servicio de Microbiología y Parasitología Clínica, Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain.Servicio de Microbiología y Parasitología Clínica, Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain.Departamento de Microbiología y Parasitología, Facultad de Farmacia, Universidad Complutense de Madrid, Madrid, Spain.Departamento de Microbiología y Parasitología, Facultad de Farmacia, Universidad Complutense de Madrid, Madrid, Spain. alexandraibanez@ucm.es.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32405804

Citation

Bolumburu, Celia, et al. "Trichomoniasis in a Tertiary Hospital of Madrid, Spain (2013-2017): Prevalence and Pregnancy Rate, Coinfections, Metronidazole Resistance, and Endosymbiosis." Parasitology Research, vol. 119, no. 6, 2020, pp. 1915-1923.
Bolumburu C, Zamora V, Muñoz-Algarra M, et al. Trichomoniasis in a tertiary hospital of Madrid, Spain (2013-2017): prevalence and pregnancy rate, coinfections, metronidazole resistance, and endosymbiosis. Parasitol Res. 2020;119(6):1915-1923.
Bolumburu, C., Zamora, V., Muñoz-Algarra, M., Portero-Azorín, F., Escario, J. A., & Ibáñez-Escribano, A. (2020). Trichomoniasis in a tertiary hospital of Madrid, Spain (2013-2017): prevalence and pregnancy rate, coinfections, metronidazole resistance, and endosymbiosis. Parasitology Research, 119(6), 1915-1923. https://doi.org/10.1007/s00436-020-06688-2
Bolumburu C, et al. Trichomoniasis in a Tertiary Hospital of Madrid, Spain (2013-2017): Prevalence and Pregnancy Rate, Coinfections, Metronidazole Resistance, and Endosymbiosis. Parasitol Res. 2020;119(6):1915-1923. PubMed PMID: 32405804.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Trichomoniasis in a tertiary hospital of Madrid, Spain (2013-2017): prevalence and pregnancy rate, coinfections, metronidazole resistance, and endosymbiosis. AU - Bolumburu,Celia, AU - Zamora,Vega, AU - Muñoz-Algarra,María, AU - Portero-Azorín,Francisca, AU - Escario,José Antonio, AU - Ibáñez-Escribano,Alexandra, Y1 - 2020/05/14/ PY - 2020/01/26/received PY - 2020/04/07/accepted PY - 2020/5/15/pubmed PY - 2020/7/11/medline PY - 2020/5/15/entrez KW - Coinfections KW - Metronidazole resistance KW - Pregnancy KW - Prevalence KW - Symbiosis KW - Trichomonas vaginalis SP - 1915 EP - 1923 JF - Parasitology research JO - Parasitol. Res. VL - 119 IS - 6 N2 - Trichomoniasis is the most prevalent curable sexually transmitted infection (STI) worldwide and a risk factor for the acquisition of other STIs and adverse pregnancy outcomes. The objectives of this study were to determine the prevalence of T. vaginalis and related coinfections in women attending a third-level hospital of Madrid (Spain). A retrospective study of 24,173 vaginal exudates from women with suspected vaginitis was conducted between 2013 and 2017. Likewise, among T. vaginalis positive samples, co-occurrence with gonorrhea, chlamydia, syphilis, VIH, Mycoplasma hominis, and Ureaplasma urealyticum was checked. Moreover, seven T. vaginalis isolates from 2017 were randomly collected for endobionts, drug resistance, and microsatellite (MS) instability determinations. The prevalence of T. vaginalis was 0.8% between 2013 and 2017. Less than 20% of patients with trichomoniasis were submitted to a complete screening for other genital pathogens. From that, two patients were coinfected with chlamydia and three with syphilis. Surprisingly, 6.4% of positive samples were diagnosed among pregnant women, showing an alarming increase from 3.2% (2014) to 10% (2017). Among the isolates randomly analyzed, five carried T. vaginalis virus, five harbored mycoplasmas, and one was metronidazole-resistant. The molecular genotyping showed a high variability in the three MS evaluated. To our knowledge, this is the first study in Spain that evaluates the prevalence of trichomoniasis in general and pregnant population and includes biomolecular determinations. These results warn about the increasing prevalence and highlight the importance of including T. vaginalis detection in routine gynecological revisions with special emphasis on childbearing age women and patients with previous STIs. SN - 1432-1955 UR - https://www.unboundmedicine.com/medline/citation/32405804/Trichomoniasis_in_a_tertiary_hospital_of_Madrid,_Spain_(2013-2017):_prevalence_and_pregnancy_rate,_coinfections,_metronidazole_resistance,_and_endosymbiosis L2 - https://dx.doi.org/10.1007/s00436-020-06688-2 DB - PRIME DP - Unbound Medicine ER -