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Central serous chorioretinopathy: An update on risk factors, pathophysiology and imaging modalities.
Prog Retin Eye Res. 2020 May 11 [Online ahead of print]PR

Abstract

Central serous chorioretinopathy (CSC) is a common form of vision loss, typically seen in working-age men. The pathophysiology behind CSC still eludes us, however significant advances have been made in understanding this disease over the last decade using information from genetic and cell-based studies and imaging modalities. This review aims to give an overview of the current pathophysiology hypotheses surrounding CSC in addition to future directions in cellular work from human induced pluripotent stem cell derived choroidal endothelial cells from CSC patients. Furthermore, this review will provide the reader with an update on the clinical aspects of CSC including risk factors, diagnostic challenges and findings from multimodal imaging.

Authors+Show Affiliations

Faculty of Medicine, University of Southampton, University Hospital Southampton, Southampton, SO16 6YD, United Kingdom.NIHR Moorfields Biomedical Research Centre, 162, City Road, London, EC1V 2PD, United Kingdom.Surya Eye Institute and Research Center, Mumbai, India.Leiden University Medical Centre, Department of Ophthalmology, P.O. Box 9600, 2300 RC, Leiden, the Netherlands; Amsterdam University Medical Centers, Department of Ophthalmology, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.NIHR Moorfields Biomedical Research Centre, 162, City Road, London, EC1V 2PD, United Kingdom.Faculty of Medicine, University of Southampton, University Hospital Southampton, Southampton, SO16 6YD, United Kingdom. Electronic address: a.j.lotery@soton.ac.uk.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32407978

Citation

Kaye, Rebecca, et al. "Central Serous Chorioretinopathy: an Update On Risk Factors, Pathophysiology and Imaging Modalities." Progress in Retinal and Eye Research, 2020, p. 100865.
Kaye R, Chandra S, Sheth J, et al. Central serous chorioretinopathy: An update on risk factors, pathophysiology and imaging modalities. Prog Retin Eye Res. 2020.
Kaye, R., Chandra, S., Sheth, J., Boon, C. J. F., Sivaprasad, S., & Lotery, A. (2020). Central serous chorioretinopathy: An update on risk factors, pathophysiology and imaging modalities. Progress in Retinal and Eye Research, 100865. https://doi.org/10.1016/j.preteyeres.2020.100865
Kaye R, et al. Central Serous Chorioretinopathy: an Update On Risk Factors, Pathophysiology and Imaging Modalities. Prog Retin Eye Res. 2020 May 11;100865. PubMed PMID: 32407978.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Central serous chorioretinopathy: An update on risk factors, pathophysiology and imaging modalities. AU - Kaye,Rebecca, AU - Chandra,Shruti, AU - Sheth,Jay, AU - Boon,Camiel J F, AU - Sivaprasad,Sobha, AU - Lotery,Andrew, Y1 - 2020/05/11/ PY - 2019/03/05/received PY - 2020/04/02/revised PY - 2020/04/27/accepted PY - 2020/5/15/pubmed PY - 2020/5/15/medline PY - 2020/5/15/entrez KW - Central serous chorioretinopathy (CSC) KW - Choroid KW - Choroidal endothelial cells (CECs) KW - Complement factor H (CFH) KW - Corticosteroids KW - Eplerenone KW - Hyperpermeability KW - Mineralocorticoids KW - Pachychoroid KW - Retinal pigment epithelium (RPE) SP - 100865 EP - 100865 JF - Progress in retinal and eye research JO - Prog Retin Eye Res N2 - Central serous chorioretinopathy (CSC) is a common form of vision loss, typically seen in working-age men. The pathophysiology behind CSC still eludes us, however significant advances have been made in understanding this disease over the last decade using information from genetic and cell-based studies and imaging modalities. This review aims to give an overview of the current pathophysiology hypotheses surrounding CSC in addition to future directions in cellular work from human induced pluripotent stem cell derived choroidal endothelial cells from CSC patients. Furthermore, this review will provide the reader with an update on the clinical aspects of CSC including risk factors, diagnostic challenges and findings from multimodal imaging. SN - 1873-1635 UR - https://www.unboundmedicine.com/medline/citation/32407978/Central_serous_chorioretinopathy:_An_update_on_risk_factors,_pathophysiology_and_imaging_modalities L2 - https://linkinghub.elsevier.com/retrieve/pii/S1350-9462(20)30037-9 DB - PRIME DP - Unbound Medicine ER -
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