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Reduction of protein intake decreases glomerular filtration rate in young type 1 (insulin-dependent) diabetic patients mainly in hyperfiltering patients.
Diabetologia. 1988 Dec; 31(12):878-83.D

Abstract

The influence of different protein intake on renal function was studied in 16 Type 1 (insulin-dependent) diabetic patients, aged 15-23 years, with onset of diabetes before puberty and with a duration of diabetes between 5 and 20 years. The glomerular filtration rate, renal plasma flow, albumin excretion rate, and blood pressure were examined in a cross-over randomised order after 10 days on isocaloric diets with either 10% (i.e. 0.9 +/- 0.06 g.kg-1.day-1) or 20% (1.9 +/- 0.1 g.kg-1.day-1) of the calories as protein, the latter being equal to the recommended diet. Dietary compliance was evaluated using fractional phosphate excretion and overnight urea excretion. Glomerular filtration rate was lower after the low-protein diet compared to the usual protein diet (p less than 0.001). Patients with glomerular filtration rate above +2 SD of the normal mean on the usual protein diet (n = 6) exhibited the steepest fall in glomerular filtration rate with a mean decrease of 20 ml/min compared to 7 ml/min in those with initially normal glomerular filtration (p = 0.01). Filtration fraction tended to decrease on low protein diet, more so in initially hyperfiltering patients (p = 0.09). Renal plasma flow remained unchanged. In patients with elevated glomerular filtration rate on usual protein diet, albumin excretion rate and systolic, but not diastolic blood pressure, were decreased on low protein diet (p = 0.03 and p = 0.01, respectively) but not in initially normal-filtering patients. Mean blood glucose and serum fructosamine were unchanged on both diets.(ABSTRACT TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Department of Paediatrics, Karolinska Institute, Stockholm, Sweden.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3240842

Citation

Rudberg, S, et al. "Reduction of Protein Intake Decreases Glomerular Filtration Rate in Young Type 1 (insulin-dependent) Diabetic Patients Mainly in Hyperfiltering Patients." Diabetologia, vol. 31, no. 12, 1988, pp. 878-83.
Rudberg S, Dahlquist G, Aperia A, et al. Reduction of protein intake decreases glomerular filtration rate in young type 1 (insulin-dependent) diabetic patients mainly in hyperfiltering patients. Diabetologia. 1988;31(12):878-83.
Rudberg, S., Dahlquist, G., Aperia, A., & Persson, B. (1988). Reduction of protein intake decreases glomerular filtration rate in young type 1 (insulin-dependent) diabetic patients mainly in hyperfiltering patients. Diabetologia, 31(12), 878-83.
Rudberg S, et al. Reduction of Protein Intake Decreases Glomerular Filtration Rate in Young Type 1 (insulin-dependent) Diabetic Patients Mainly in Hyperfiltering Patients. Diabetologia. 1988;31(12):878-83. PubMed PMID: 3240842.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reduction of protein intake decreases glomerular filtration rate in young type 1 (insulin-dependent) diabetic patients mainly in hyperfiltering patients. AU - Rudberg,S, AU - Dahlquist,G, AU - Aperia,A, AU - Persson,B, PY - 1988/12/1/pubmed PY - 1988/12/1/medline PY - 1988/12/1/entrez SP - 878 EP - 83 JF - Diabetologia JO - Diabetologia VL - 31 IS - 12 N2 - The influence of different protein intake on renal function was studied in 16 Type 1 (insulin-dependent) diabetic patients, aged 15-23 years, with onset of diabetes before puberty and with a duration of diabetes between 5 and 20 years. The glomerular filtration rate, renal plasma flow, albumin excretion rate, and blood pressure were examined in a cross-over randomised order after 10 days on isocaloric diets with either 10% (i.e. 0.9 +/- 0.06 g.kg-1.day-1) or 20% (1.9 +/- 0.1 g.kg-1.day-1) of the calories as protein, the latter being equal to the recommended diet. Dietary compliance was evaluated using fractional phosphate excretion and overnight urea excretion. Glomerular filtration rate was lower after the low-protein diet compared to the usual protein diet (p less than 0.001). Patients with glomerular filtration rate above +2 SD of the normal mean on the usual protein diet (n = 6) exhibited the steepest fall in glomerular filtration rate with a mean decrease of 20 ml/min compared to 7 ml/min in those with initially normal glomerular filtration (p = 0.01). Filtration fraction tended to decrease on low protein diet, more so in initially hyperfiltering patients (p = 0.09). Renal plasma flow remained unchanged. In patients with elevated glomerular filtration rate on usual protein diet, albumin excretion rate and systolic, but not diastolic blood pressure, were decreased on low protein diet (p = 0.03 and p = 0.01, respectively) but not in initially normal-filtering patients. Mean blood glucose and serum fructosamine were unchanged on both diets.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0012-186X UR - https://www.unboundmedicine.com/medline/citation/3240842/Reduction_of_protein_intake_decreases_glomerular_filtration_rate_in_young_type_1__insulin_dependent__diabetic_patients_mainly_in_hyperfiltering_patients_ DB - PRIME DP - Unbound Medicine ER -