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Coagulopathy in COVID-19: Manifestations and management.
Cleve Clin J Med. 2020 07 31; 87(8):461-468.CC

Abstract

Severe COVID-19 illness is associated with intense inflammation, leading to high rates of thrombotic complications that increase morbidity and mortality. Markedly elevated levels of D-dimer with normal fibrinogen levels are the hallmark laboratory findings of severe COVID-19- associated coagulopathy. Prophylaxis against venous thromboembolism is paramount for all hospitalized patients, with more aggressive prophylaxis and screening recommended for patients with D-dimer levels above 3.0 μg/mL. Point-of-care ultrasonography is the imaging method of choice for patients at high risk, as it entails minimal risk of exposing providers to the virus.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Mucha SR
Critical Care Medicine, Respiratory Institute, Cleveland Clinic. Clinical Instructor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH.
Dugar S
Pulmonary Medicine, Cleveland Clinic. Clinical Assistant Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH.
McCrae K
Hematology and Medical Oncology, and Cellular and Molecular Medicine, Cleveland Clinic. Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH.
Joseph D
Cardiovascular Medicine, Cleveland Clinic. Assistant Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH.
Bartholomew J
Cardiovascular Medicine, Cleveland Clinic barthoj@ccf.org. Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH barthoj@ccf.org.
Sacha GL
Inpatient Pharmacy, Cleveland Clinic.
Militello M
Inpatient Pharmacy, Cleveland Clinic.

MeSH

AnticoagulantsBetacoronavirusBlood CoagulationBlood Coagulation DisordersBlood Coagulation TestsCOVID-19ChemopreventionCoronavirus InfectionsFibrin Fibrinogen Degradation ProductsHumansMonitoring, PhysiologicPandemicsPneumonia, ViralSARS-CoV-2Thrombosis

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32409435

Citation

Mucha, Simon R., et al. "Coagulopathy in COVID-19: Manifestations and Management." Cleveland Clinic Journal of Medicine, vol. 87, no. 8, 2020, pp. 461-468.
Mucha SR, Dugar S, McCrae K, et al. Coagulopathy in COVID-19: Manifestations and management. Cleve Clin J Med. 2020;87(8):461-468.
Mucha, S. R., Dugar, S., McCrae, K., Joseph, D., Bartholomew, J., Sacha, G. L., & Militello, M. (2020). Coagulopathy in COVID-19: Manifestations and management. Cleveland Clinic Journal of Medicine, 87(8), 461-468. https://doi.org/10.3949/ccjm.87a.ccc024
Mucha SR, et al. Coagulopathy in COVID-19: Manifestations and Management. Cleve Clin J Med. 2020 07 31;87(8):461-468. PubMed PMID: 32409435.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Coagulopathy in COVID-19: Manifestations and management. AU - Mucha,Simon R, AU - Dugar,Siddharth, AU - McCrae,Keith, AU - Joseph,Douglas, AU - Bartholomew,John, AU - Sacha,Gretchen L, AU - Militello,Michael, Y1 - 2020/07/31/ PY - 2020/5/16/pubmed PY - 2020/8/12/medline PY - 2020/5/16/entrez SP - 461 EP - 468 JF - Cleveland Clinic journal of medicine JO - Cleve Clin J Med VL - 87 IS - 8 N2 - Severe COVID-19 illness is associated with intense inflammation, leading to high rates of thrombotic complications that increase morbidity and mortality. Markedly elevated levels of D-dimer with normal fibrinogen levels are the hallmark laboratory findings of severe COVID-19- associated coagulopathy. Prophylaxis against venous thromboembolism is paramount for all hospitalized patients, with more aggressive prophylaxis and screening recommended for patients with D-dimer levels above 3.0 μg/mL. Point-of-care ultrasonography is the imaging method of choice for patients at high risk, as it entails minimal risk of exposing providers to the virus. SN - 1939-2869 UR - https://www.unboundmedicine.com/medline/citation/32409435/Coagulopathy_in_COVID_19:_Manifestations_and_management_ DB - PRIME DP - Unbound Medicine ER -