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Expressions and significances of the angiotensin-converting enzyme 2 gene, the receptor of SARS-CoV-2 for COVID-19.
Mol Biol Rep. 2020 Jun; 47(6):4383-4392.MB

Abstract

The ACE2 gene is a receptor of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) for COVID-19 (coronavirus disease 2019). To analyze the expression profiles and clinical significances for this gene in humans, RNA-seq data representing 27 different tissues were analyzed using NCBI; total RNA was extracted from different tissues of mouse and semi-quantitative reverse transcriptional-polymerase chain reaction (Q-RT-PCR) was carried out. Immunohistochemistry expression profiles in normal tissues and cancer tissues and TCGA survival analysis in renal and liver cancer were conducted. ACE2 was highly conserved in different species. In normal tissues, ACE2 expression distributions were organ-specific, mainly in the kidney, male testis and female breast, and cardiovascular and gastrointestinal systems. High level of expression in testis, cardiovascular and gastrointestinal system indicated that SARS-CoV-2 might not only attack the lungs, but also affect other organs, particularly the testes, thus it may severely damage male sexual development for younger male and lead to infertility in an adult male, if he contracted COVID-19. On the other side, high expression of ACE2 was correlated with increased survival rate in renal and liver cancer, indicating that ACE2 is a prognostic marker in both renal cancer and liver cancers. Thus, the ACE2 is a functional receptor for SARS-CoV-2 and has a potential anti-tumor role in cancer. Taken together, this study may not only provide potential clues for further medical pathogenesis of COVID-19 and male fertility, but also indicate the clinical significance of the role of the ACE2 gene in cancer.

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Authors+Show Affiliations

Fu J
Key Laboratory of Epigenetics and Oncology, the Research Center for Preclinical Medicine, Southwest Medical University, Luzhou, 646000, Sichuan Province, China.
Zhou B
Key Laboratory of Epigenetics and Oncology, the Research Center for Preclinical Medicine, Southwest Medical University, Luzhou, 646000, Sichuan Province, China. Department of Gynecology and Obstetrics, Guangdong Women and Children Hospital, Guangzhou, Guangdong, China.
Zhang L
Key Laboratory of Epigenetics and Oncology, the Research Center for Preclinical Medicine, Southwest Medical University, Luzhou, 646000, Sichuan Province, China. Department of Pathology, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huai'an, China.
Balaji KS
Post Graduation Department of Studies and Research in Biotechnology, Teresian Research Center, Teresian College (Affiliated to University of Mysore), Siddhartha Nagara, Mysore, Karnataka, 570011, India.
Wei C
Key Laboratory of Epigenetics and Oncology, the Research Center for Preclinical Medicine, Southwest Medical University, Luzhou, 646000, Sichuan Province, China.
Liu X
Key Laboratory of Epigenetics and Oncology, the Research Center for Preclinical Medicine, Southwest Medical University, Luzhou, 646000, Sichuan Province, China.
Chen H
Department of Biochemistry and Molecular Biology, School of Life Sciences, Central South University, Changsha, 410013, China.
Peng J
Department of Thoracic Surgery, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China. jiangzhou83@163.com.
Fu J
Key Laboratory of Epigenetics and Oncology, the Research Center for Preclinical Medicine, Southwest Medical University, Luzhou, 646000, Sichuan Province, China. fujunjiang@hotmail.com.

MeSH

AdultAngiotensin-Converting Enzyme 2AnimalsBetacoronavirusCOVID-19Coronavirus InfectionsDatabases, GeneticFemaleGene Expression RegulationHost-Pathogen InteractionsHumansKidneyKidney NeoplasmsLiverLiver NeoplasmsLungMaleMammary Glands, HumanMicePandemicsPeptidyl-Dipeptidase APneumonia, ViralProtein BindingReceptors, VirusSARS-CoV-2Sequence Analysis, RNASignal TransductionSpike Glycoprotein, CoronavirusSurvival AnalysisTestis

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32410141

Citation

Fu, Jiewen, et al. "Expressions and Significances of the Angiotensin-converting Enzyme 2 Gene, the Receptor of SARS-CoV-2 for COVID-19." Molecular Biology Reports, vol. 47, no. 6, 2020, pp. 4383-4392.
Fu J, Zhou B, Zhang L, et al. Expressions and significances of the angiotensin-converting enzyme 2 gene, the receptor of SARS-CoV-2 for COVID-19. Mol Biol Rep. 2020;47(6):4383-4392.
Fu, J., Zhou, B., Zhang, L., Balaji, K. S., Wei, C., Liu, X., Chen, H., Peng, J., & Fu, J. (2020). Expressions and significances of the angiotensin-converting enzyme 2 gene, the receptor of SARS-CoV-2 for COVID-19. Molecular Biology Reports, 47(6), 4383-4392. https://doi.org/10.1007/s11033-020-05478-4
Fu J, et al. Expressions and Significances of the Angiotensin-converting Enzyme 2 Gene, the Receptor of SARS-CoV-2 for COVID-19. Mol Biol Rep. 2020;47(6):4383-4392. PubMed PMID: 32410141.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Expressions and significances of the angiotensin-converting enzyme 2 gene, the receptor of SARS-CoV-2 for COVID-19. AU - Fu,Jiewen, AU - Zhou,Baixu, AU - Zhang,Lianmei, AU - Balaji,Kyathegowdanadoddi Srinivasa, AU - Wei,Chunli, AU - Liu,Xiaoyan, AU - Chen,Hanchun, AU - Peng,Jiangzhou, AU - Fu,Junjiang, Y1 - 2020/05/14/ PY - 2020/3/25/received PY - 2020/4/28/accepted PY - 2020/5/16/pubmed PY - 2020/6/26/medline PY - 2020/5/16/entrez KW - ACE2 gene KW - COVID-19 KW - Cancer KW - Immunohistochemistry (IHC) KW - RNA-sequencing KW - SARS-CoV-2 KW - Testis SP - 4383 EP - 4392 JF - Molecular biology reports JO - Mol Biol Rep VL - 47 IS - 6 N2 - The ACE2 gene is a receptor of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) for COVID-19 (coronavirus disease 2019). To analyze the expression profiles and clinical significances for this gene in humans, RNA-seq data representing 27 different tissues were analyzed using NCBI; total RNA was extracted from different tissues of mouse and semi-quantitative reverse transcriptional-polymerase chain reaction (Q-RT-PCR) was carried out. Immunohistochemistry expression profiles in normal tissues and cancer tissues and TCGA survival analysis in renal and liver cancer were conducted. ACE2 was highly conserved in different species. In normal tissues, ACE2 expression distributions were organ-specific, mainly in the kidney, male testis and female breast, and cardiovascular and gastrointestinal systems. High level of expression in testis, cardiovascular and gastrointestinal system indicated that SARS-CoV-2 might not only attack the lungs, but also affect other organs, particularly the testes, thus it may severely damage male sexual development for younger male and lead to infertility in an adult male, if he contracted COVID-19. On the other side, high expression of ACE2 was correlated with increased survival rate in renal and liver cancer, indicating that ACE2 is a prognostic marker in both renal cancer and liver cancers. Thus, the ACE2 is a functional receptor for SARS-CoV-2 and has a potential anti-tumor role in cancer. Taken together, this study may not only provide potential clues for further medical pathogenesis of COVID-19 and male fertility, but also indicate the clinical significance of the role of the ACE2 gene in cancer. SN - 1573-4978 UR - https://www.unboundmedicine.com/medline/citation/32410141/Expressions_and_significances_of_the_angiotensin_converting_enzyme_2_gene_the_receptor_of_SARS_CoV_2_for_COVID_19_ DB - PRIME DP - Unbound Medicine ER -