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Effects of multidomain versus single-domain training on executive control and memory in older adults: study protocol for a randomized controlled trial.
Trials. 2020 May 14; 21(1):404.T

Abstract

BACKGROUND

Previous research suggests that both cognitive training and physical exercise help to maintain brain health and cognitive functions that decline with age. Some studies indicate that combined interventions may produce larger effects than each intervention alone. The aim of this study is to investigate the effects of combined cognitive and physical training compared to cognitive training and physical training alone on executive control and memory functions in healthy older adults.

OBJECTIVES

The main objectives of this four-arm randomized controlled trial (RCT) are: to investigate the synergetic effects of a simultaneous, group-based multidomain training program that combines cognitive video-game training with physical exercise, in comparison to those produced by cognitive training combined with physical control activity, physical training combined with cognitive control activity, or a combination of both control activities; to investigate whether event-related potential latencies of the P2 component are shorter and N2 and P3b components assessed in a memory-based task switching task are enhanced after training; and to find out whether possible enhancements persist after a 3-month period without training.

METHODS

In this randomized, single-blind, controlled trial, 144 participants will be randomly assigned to one of the four combinations of cognitive training and physical exercise. The cognitive component will be either video-game training (cognitive intervention, CI) or video games not specifically designed to train cognition (cognitive control, CC). The physical exercise component will either emphasize endurance, strength, and music-movement coordination (exercise intervention, EI) or stretching, toning, and relaxation (exercise control, EC).

DISCUSSION

This RCT will investigate the short and long-term effects of multidomain training, compared to cognitive training and physical training alone, on executive control and memory functions in healthy older adults, in comparison with the performance of an active control group.

TRIAL REGISTRATION

ClinicalTrials.gov, NCT03823183. Registered on 21 January 2019.

Authors+Show Affiliations

Studies on Aging and Neurodegenerative Diseases Research Group, Universidad Nacional de Educación a Distancia, Madrid, Spain. mballesteros@psi.uned.es. Department of Basic Psychology II, Facultad de Psicología, Universidad Nacional de Educación a Distancia, Juan del Rosal, 10, Madrid, Spain. mballesteros@psi.uned.es.Studies on Aging and Neurodegenerative Diseases Research Group, Universidad Nacional de Educación a Distancia, Madrid, Spain. Department of Basic Psychology II, Facultad de Psicología, Universidad Nacional de Educación a Distancia, Juan del Rosal, 10, Madrid, Spain.Studies on Aging and Neurodegenerative Diseases Research Group, Universidad Nacional de Educación a Distancia, Madrid, Spain. Department of Basic Psychology II, Facultad de Psicología, Universidad Nacional de Educación a Distancia, Juan del Rosal, 10, Madrid, Spain.Studies on Aging and Neurodegenerative Diseases Research Group, Universidad Nacional de Educación a Distancia, Madrid, Spain. Department of Basic Psychology II, Facultad de Psicología, Universidad Nacional de Educación a Distancia, Juan del Rosal, 10, Madrid, Spain.Studies on Aging and Neurodegenerative Diseases Research Group, Universidad Nacional de Educación a Distancia, Madrid, Spain.Studies on Aging and Neurodegenerative Diseases Research Group, Universidad Nacional de Educación a Distancia, Madrid, Spain. Department of Basic Psychology II, Facultad de Psicología, Universidad Nacional de Educación a Distancia, Juan del Rosal, 10, Madrid, Spain.Studies on Aging and Neurodegenerative Diseases Research Group, Universidad Nacional de Educación a Distancia, Madrid, Spain. Department Methodology of Behavioral Sciences, Facultad de Psicología, Universidad Nacional de Educación a Distancia, Madrid, Spain.

Pub Type(s)

Clinical Trial Protocol
Journal Article

Language

eng

PubMed ID

32410715

Citation

Ballesteros, Soledad, et al. "Effects of Multidomain Versus Single-domain Training On Executive Control and Memory in Older Adults: Study Protocol for a Randomized Controlled Trial." Trials, vol. 21, no. 1, 2020, p. 404.
Ballesteros S, Rieker JA, Mayas J, et al. Effects of multidomain versus single-domain training on executive control and memory in older adults: study protocol for a randomized controlled trial. Trials. 2020;21(1):404.
Ballesteros, S., Rieker, J. A., Mayas, J., Prieto, A., Toril, P., Jiménez, M. P., & Reales, J. M. (2020). Effects of multidomain versus single-domain training on executive control and memory in older adults: study protocol for a randomized controlled trial. Trials, 21(1), 404. https://doi.org/10.1186/s13063-020-04293-3
Ballesteros S, et al. Effects of Multidomain Versus Single-domain Training On Executive Control and Memory in Older Adults: Study Protocol for a Randomized Controlled Trial. Trials. 2020 May 14;21(1):404. PubMed PMID: 32410715.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of multidomain versus single-domain training on executive control and memory in older adults: study protocol for a randomized controlled trial. AU - Ballesteros,Soledad, AU - Rieker,Jennifer A, AU - Mayas,Julia, AU - Prieto,Antonio, AU - Toril,Pilar, AU - Jiménez,María Pilar, AU - Reales,José Manuel, Y1 - 2020/05/14/ PY - 2019/03/29/received PY - 2020/03/30/accepted PY - 2020/5/16/entrez PY - 2020/5/16/pubmed PY - 2021/1/26/medline KW - Aging KW - Cognitive training KW - Executive functions KW - Memory functions KW - Multidomain training KW - Physical exercise KW - Randomized controlled trial SP - 404 EP - 404 JF - Trials JO - Trials VL - 21 IS - 1 N2 - BACKGROUND: Previous research suggests that both cognitive training and physical exercise help to maintain brain health and cognitive functions that decline with age. Some studies indicate that combined interventions may produce larger effects than each intervention alone. The aim of this study is to investigate the effects of combined cognitive and physical training compared to cognitive training and physical training alone on executive control and memory functions in healthy older adults. OBJECTIVES: The main objectives of this four-arm randomized controlled trial (RCT) are: to investigate the synergetic effects of a simultaneous, group-based multidomain training program that combines cognitive video-game training with physical exercise, in comparison to those produced by cognitive training combined with physical control activity, physical training combined with cognitive control activity, or a combination of both control activities; to investigate whether event-related potential latencies of the P2 component are shorter and N2 and P3b components assessed in a memory-based task switching task are enhanced after training; and to find out whether possible enhancements persist after a 3-month period without training. METHODS: In this randomized, single-blind, controlled trial, 144 participants will be randomly assigned to one of the four combinations of cognitive training and physical exercise. The cognitive component will be either video-game training (cognitive intervention, CI) or video games not specifically designed to train cognition (cognitive control, CC). The physical exercise component will either emphasize endurance, strength, and music-movement coordination (exercise intervention, EI) or stretching, toning, and relaxation (exercise control, EC). DISCUSSION: This RCT will investigate the short and long-term effects of multidomain training, compared to cognitive training and physical training alone, on executive control and memory functions in healthy older adults, in comparison with the performance of an active control group. TRIAL REGISTRATION: ClinicalTrials.gov, NCT03823183. Registered on 21 January 2019. SN - 1745-6215 UR - https://www.unboundmedicine.com/medline/citation/32410715/Effects_of_multidomain_versus_single_domain_training_on_executive_control_and_memory_in_older_adults:_study_protocol_for_a_randomized_controlled_trial_ L2 - https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-020-04293-3 DB - PRIME DP - Unbound Medicine ER -