Tags

Type your tag names separated by a space and hit enter

Reduction of postprandial triglyceridemia in humans by dietary n-3 fatty acids.
J Lipid Res 1988; 29(11):1451-60JL

Abstract

Long chain n-3 fatty acids present in fish oils have been shown to reduce fasting plasma triglyceride and very low density lipoprotein levels in normal and hyperlipidemic human subjects. The present studies were designed to examine whether dietary n-3 fatty acids influence chylomicron formation and metabolism in healthy volunteers. In the first study seven subjects were fed either saturated fat, vegetable oil, or fish oil-based diets for 4 weeks each, and test meals containing 50 g of the background fat were administered after the second week of each diet. The postprandial rise in triglyceride levels was significantly lower following the fish oil test meal as compared to the saturated fat or vegetable oil test meals. In the second study, six subjects eating their usual home diets were given two fat tolerance tests. The first contained saturated fat and the second, given 1 week later, contained fish oil. There was no difference in the postprandial triglyceride response between the fish oil and the saturated fat meals. A third study was then conducted with eight volunteers in which saturated fat and fish oil test meals were administered during saturated fat and fish oil background diets in a crossover design. The presence of fish oil in the background diet reduced postprandial lipemia regardless of the type of fat in the test meal. Although there was no effect of the fish oil diet on the lipoprotein lipase and hepatic lipase activity of postheparin plasma measured in vitro, stimulation of in vivo lipolysis was not ruled out. Our results suggest that chronic (but not acute) intake of fish oil may inhibit the synthesis or secretion of chylomicrons from the gut. However, accelerated clearance due to decreased VLDL competition cannot be excluded.

Authors+Show Affiliations

Department of Medicine, Oregon Health Sciences University, Portland 97201.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

3241121

Citation

Harris, W S., et al. "Reduction of Postprandial Triglyceridemia in Humans By Dietary N-3 Fatty Acids." Journal of Lipid Research, vol. 29, no. 11, 1988, pp. 1451-60.
Harris WS, Connor WE, Alam N, et al. Reduction of postprandial triglyceridemia in humans by dietary n-3 fatty acids. J Lipid Res. 1988;29(11):1451-60.
Harris, W. S., Connor, W. E., Alam, N., & Illingworth, D. R. (1988). Reduction of postprandial triglyceridemia in humans by dietary n-3 fatty acids. Journal of Lipid Research, 29(11), pp. 1451-60.
Harris WS, et al. Reduction of Postprandial Triglyceridemia in Humans By Dietary N-3 Fatty Acids. J Lipid Res. 1988;29(11):1451-60. PubMed PMID: 3241121.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reduction of postprandial triglyceridemia in humans by dietary n-3 fatty acids. AU - Harris,W S, AU - Connor,W E, AU - Alam,N, AU - Illingworth,D R, PY - 1988/11/1/pubmed PY - 1988/11/1/medline PY - 1988/11/1/entrez SP - 1451 EP - 60 JF - Journal of lipid research JO - J. Lipid Res. VL - 29 IS - 11 N2 - Long chain n-3 fatty acids present in fish oils have been shown to reduce fasting plasma triglyceride and very low density lipoprotein levels in normal and hyperlipidemic human subjects. The present studies were designed to examine whether dietary n-3 fatty acids influence chylomicron formation and metabolism in healthy volunteers. In the first study seven subjects were fed either saturated fat, vegetable oil, or fish oil-based diets for 4 weeks each, and test meals containing 50 g of the background fat were administered after the second week of each diet. The postprandial rise in triglyceride levels was significantly lower following the fish oil test meal as compared to the saturated fat or vegetable oil test meals. In the second study, six subjects eating their usual home diets were given two fat tolerance tests. The first contained saturated fat and the second, given 1 week later, contained fish oil. There was no difference in the postprandial triglyceride response between the fish oil and the saturated fat meals. A third study was then conducted with eight volunteers in which saturated fat and fish oil test meals were administered during saturated fat and fish oil background diets in a crossover design. The presence of fish oil in the background diet reduced postprandial lipemia regardless of the type of fat in the test meal. Although there was no effect of the fish oil diet on the lipoprotein lipase and hepatic lipase activity of postheparin plasma measured in vitro, stimulation of in vivo lipolysis was not ruled out. Our results suggest that chronic (but not acute) intake of fish oil may inhibit the synthesis or secretion of chylomicrons from the gut. However, accelerated clearance due to decreased VLDL competition cannot be excluded. SN - 0022-2275 UR - https://www.unboundmedicine.com/medline/citation/3241121/Reduction_of_postprandial_triglyceridemia_in_humans_by_dietary_n_3_fatty_acids_ L2 - http://www.jlr.org/cgi/pmidlookup?view=long&pmid=3241121 DB - PRIME DP - Unbound Medicine ER -