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Is the kidney a target of SARS-CoV-2?
Am J Physiol Renal Physiol. 2020 06 01; 318(6):F1454-F1462.AJ

Abstract

The new disease produced by severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) represents a major pandemic event nowadays. Since its origin in China in December 2019, there is compelling evidence that novel SARS-CoV-2 is a highly transmissible virus, and it is associated to a broad clinical spectrum going from subclinical presentation to severe respiratory distress and multiorgan failure. Like other coronaviruses, SARS-CoV-2 recognizes human angiotensin-converting enzyme 2 as a cellular receptor that allows it to infect different host cells and likely disrupts renin-angiotensin-aldosterone system homeostasis. Particularly, a considerable incidence of many renal abnormalities associated to COVID-19 has been reported, including proteinuria, hematuria, and acute kidney injury. Moreover, it has been recently demonstrated that SARS-CoV-2 can infect podocytes and tubular epithelial cells, which could contribute to the development of the aforementioned renal abnormalities. In this review, we discuss the biological aspects of SARS-CoV-2 infection, how understanding current knowledge about SARS-CoV-2 infection may partly explain the involvement of the kidneys in the pathophysiology of COVID-19, and what questions have arisen and remain to be explored.

Authors+Show Affiliations

Molecular Physiology Unit, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad de México, México. Department of Nephrology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México, México.Department of Nephrology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México, México.Molecular Physiology Unit, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad de México, México. Department of Nephrology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México, México.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

32412303

Citation

Martinez-Rojas, Miguel Angel, et al. "Is the Kidney a Target of SARS-CoV-2?" American Journal of Physiology. Renal Physiology, vol. 318, no. 6, 2020, pp. F1454-F1462.
Martinez-Rojas MA, Vega-Vega O, Bobadilla NA. Is the kidney a target of SARS-CoV-2? Am J Physiol Renal Physiol. 2020;318(6):F1454-F1462.
Martinez-Rojas, M. A., Vega-Vega, O., & Bobadilla, N. A. (2020). Is the kidney a target of SARS-CoV-2? American Journal of Physiology. Renal Physiology, 318(6), F1454-F1462. https://doi.org/10.1152/ajprenal.00160.2020
Martinez-Rojas MA, Vega-Vega O, Bobadilla NA. Is the Kidney a Target of SARS-CoV-2. Am J Physiol Renal Physiol. 2020 06 1;318(6):F1454-F1462. PubMed PMID: 32412303.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Is the kidney a target of SARS-CoV-2? AU - Martinez-Rojas,Miguel Angel, AU - Vega-Vega,Olynka, AU - Bobadilla,Norma A, Y1 - 2020/05/15/ PY - 2020/5/16/pubmed PY - 2020/6/17/medline PY - 2020/5/16/entrez KW - COVID-19 KW - acute kidney injury KW - angiotensin-converting enzyme 2 KW - proteinuria KW - renin-angiotensin-aldosterone system SP - F1454 EP - F1462 JF - American journal of physiology. Renal physiology JO - Am. J. Physiol. Renal Physiol. VL - 318 IS - 6 N2 - The new disease produced by severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) represents a major pandemic event nowadays. Since its origin in China in December 2019, there is compelling evidence that novel SARS-CoV-2 is a highly transmissible virus, and it is associated to a broad clinical spectrum going from subclinical presentation to severe respiratory distress and multiorgan failure. Like other coronaviruses, SARS-CoV-2 recognizes human angiotensin-converting enzyme 2 as a cellular receptor that allows it to infect different host cells and likely disrupts renin-angiotensin-aldosterone system homeostasis. Particularly, a considerable incidence of many renal abnormalities associated to COVID-19 has been reported, including proteinuria, hematuria, and acute kidney injury. Moreover, it has been recently demonstrated that SARS-CoV-2 can infect podocytes and tubular epithelial cells, which could contribute to the development of the aforementioned renal abnormalities. In this review, we discuss the biological aspects of SARS-CoV-2 infection, how understanding current knowledge about SARS-CoV-2 infection may partly explain the involvement of the kidneys in the pathophysiology of COVID-19, and what questions have arisen and remain to be explored. SN - 1522-1466 UR - https://www.unboundmedicine.com/medline/citation/32412303/Is_the_kidney_a_target_of_SARS_CoV_2 L2 - https://journals.physiology.org/doi/10.1152/ajprenal.00160.2020?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=www.ncbi.nlm.nih.gov DB - PRIME DP - Unbound Medicine ER -