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Multiple porokeratomas (porokeratotic acanthoma) coexisting with disseminated superficial porokeratosis: Clinical, dermoscopic and pathological observations, and review of published work.
J Dermatol. 2020 Jul; 47(7):787-791.JD

Abstract

Porokeratoma is a recently described solitary or multiple tumor-like acanthoma, sharing the histological feature of cornoid lamellae with porokeratosis. Whether porokeratoma is a variant of porokeratosis is controversial. We report a rare case of a 53-year-old Chinese woman who presented with multiple, symmetrical, hemispherical and verrucous plaques on her lower extremities that had been present for 20 years. The clinical manifestation resembled the fungal disease of chromoblastomycosis. The diagnosis of multiple porokeratoma coexisting with disseminated superficial porokeratosis was rendered according to the clinical, dermoscopic and pathological features. Oral acitretin (30 mg/day) and laser therapy were administrated. After 6 months of treatment, the number of plaques on her limbs was significantly reduced without recurrence. From this case, we speculate that porokeratoma is a rare and special variant of porokeratosis. In complex cases with multiple lesions, oral acitretin can be combined with surgery, cryotherapy and laser therapy.

Authors+Show Affiliations

Department of Dermatology, Rare Disease Center, West China Hospital, Sichuan University, Chengdu, China.Department of Dermatology, Rare Disease Center, West China Hospital, Sichuan University, Chengdu, China.Department of Dermatology, Rare Disease Center, West China Hospital, Sichuan University, Chengdu, China.Department of Dermatology, Rare Disease Center, West China Hospital, Sichuan University, Chengdu, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32415691

Citation

Xu, Xiaoxi, et al. "Multiple Porokeratomas (porokeratotic Acanthoma) Coexisting With Disseminated Superficial Porokeratosis: Clinical, Dermoscopic and Pathological Observations, and Review of Published Work." The Journal of Dermatology, vol. 47, no. 7, 2020, pp. 787-791.
Xu X, Pradhan S, Wang D, et al. Multiple porokeratomas (porokeratotic acanthoma) coexisting with disseminated superficial porokeratosis: Clinical, dermoscopic and pathological observations, and review of published work. J Dermatol. 2020;47(7):787-791.
Xu, X., Pradhan, S., Wang, D., & Li, W. (2020). Multiple porokeratomas (porokeratotic acanthoma) coexisting with disseminated superficial porokeratosis: Clinical, dermoscopic and pathological observations, and review of published work. The Journal of Dermatology, 47(7), 787-791. https://doi.org/10.1111/1346-8138.15376
Xu X, et al. Multiple Porokeratomas (porokeratotic Acanthoma) Coexisting With Disseminated Superficial Porokeratosis: Clinical, Dermoscopic and Pathological Observations, and Review of Published Work. J Dermatol. 2020;47(7):787-791. PubMed PMID: 32415691.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Multiple porokeratomas (porokeratotic acanthoma) coexisting with disseminated superficial porokeratosis: Clinical, dermoscopic and pathological observations, and review of published work. AU - Xu,Xiaoxi, AU - Pradhan,Sushmita, AU - Wang,Dan, AU - Li,Wei, Y1 - 2020/05/15/ PY - 2020/01/06/received PY - 2020/04/06/accepted PY - 2020/5/18/pubmed PY - 2020/5/18/medline PY - 2020/5/17/entrez KW - acitretin KW - cornoid lamellae KW - dermoscopy KW - disseminated superficial porokeratosis KW - porokeratoma SP - 787 EP - 791 JF - The Journal of dermatology JO - J. Dermatol. VL - 47 IS - 7 N2 - Porokeratoma is a recently described solitary or multiple tumor-like acanthoma, sharing the histological feature of cornoid lamellae with porokeratosis. Whether porokeratoma is a variant of porokeratosis is controversial. We report a rare case of a 53-year-old Chinese woman who presented with multiple, symmetrical, hemispherical and verrucous plaques on her lower extremities that had been present for 20 years. The clinical manifestation resembled the fungal disease of chromoblastomycosis. The diagnosis of multiple porokeratoma coexisting with disseminated superficial porokeratosis was rendered according to the clinical, dermoscopic and pathological features. Oral acitretin (30 mg/day) and laser therapy were administrated. After 6 months of treatment, the number of plaques on her limbs was significantly reduced without recurrence. From this case, we speculate that porokeratoma is a rare and special variant of porokeratosis. In complex cases with multiple lesions, oral acitretin can be combined with surgery, cryotherapy and laser therapy. SN - 1346-8138 UR - https://www.unboundmedicine.com/medline/citation/32415691/Multiple_porokeratomas_(porokeratotic_acanthoma)_coexisting_with_disseminated_superficial_porokeratosis:_Clinical,_dermoscopic_and_pathological_observations,_and_review_of_published_work L2 - https://doi.org/10.1111/1346-8138.15376 DB - PRIME DP - Unbound Medicine ER -
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