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Antioxidant and anti-inflammatory properties of orally disintegrating films based on starch and hydroxypropyl methylcellulose incorporated with Cordia verbenacea (erva baleeira) extract.
Int J Biol Macromol. 2020 May 13; 159:714-724.IJ

Abstract

Cordia verbenacea (erva baleeira) is a plant used in indigenous folk medicine. Due to its pharmacological properties (antioxidant and anti-inflammatory), it can be used in the development of herbal medicines by different forms of administration such as orally disintegrating films (ODFs), which would facilitate the systemic release of its active ingredients. Considering the properties of the C. verbenacea and the advantages of ODFs, the objective of this work was the potential development of ODFs with antioxidant and anti-inflammatory properties. The polymeric matrices were produced based on starch and hydroxypropyl methylcellulose and additives with different C. verbenacea extract concentrations in order to obtain concentrations of 0.25, 0.50 and 0.75 mg flavonoids/ODF. The films were characterized by microscopy, infrared spectroscopy, mechanical properties, mucoadhesiveness, in vitro disintegration, in vitro release of flavonoids, antioxidant, and anti-inflammatory activities of the films. The ODFs showed good antioxidant activity and high anti-inflammatory capacity with inhibition of COX-2 enzyme. The stability study demonstrated the conservation of flavonoids and also the maintenance of the anti-inflammatory capacity of ODFs. This study demonstrated that orally disintegrating films have high potential for the delivery of natural bioactive compounds and the maintenance of their pharmacological properties.

Authors+Show Affiliations

Food Engineering Department (FZEA/USP), College of Animal Science and Food Engineering, University of São Paulo, Avenida Duque de Caxias Norte, 225, CEP 13635-900 Pirassununga, São Paulo, Brazil. Electronic address: renatabodini@usp.br.Basic Sciences Department (FZEA/USP), College of Animal Science and Food Engineering, University of São Paulo, Avenida Duque de Caxias Norte, 225, CEP 13635-900, Pirassununga, São Paulo, Brazil. Electronic address: spiccoli@usp.br.Basic Sciences Department (FZEA/USP), College of Animal Science and Food Engineering, University of São Paulo, Avenida Duque de Caxias Norte, 225, CEP 13635-900, Pirassununga, São Paulo, Brazil. Electronic address: mpmelo@usp.br.Food Engineering Department (FZEA/USP), College of Animal Science and Food Engineering, University of São Paulo, Avenida Duque de Caxias Norte, 225, CEP 13635-900 Pirassununga, São Paulo, Brazil. Electronic address: rosecarvalho@usp.br.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32416298

Citation

Bodini, Renata Barbosa, et al. "Antioxidant and Anti-inflammatory Properties of Orally Disintegrating Films Based On Starch and Hydroxypropyl Methylcellulose Incorporated With Cordia Verbenacea (erva Baleeira) Extract." International Journal of Biological Macromolecules, vol. 159, 2020, pp. 714-724.
Bodini RB, Pugine SMP, de Melo MP, et al. Antioxidant and anti-inflammatory properties of orally disintegrating films based on starch and hydroxypropyl methylcellulose incorporated with Cordia verbenacea (erva baleeira) extract. Int J Biol Macromol. 2020;159:714-724.
Bodini, R. B., Pugine, S. M. P., de Melo, M. P., & de Carvalho, R. A. (2020). Antioxidant and anti-inflammatory properties of orally disintegrating films based on starch and hydroxypropyl methylcellulose incorporated with Cordia verbenacea (erva baleeira) extract. International Journal of Biological Macromolecules, 159, 714-724. https://doi.org/10.1016/j.ijbiomac.2020.05.075
Bodini RB, et al. Antioxidant and Anti-inflammatory Properties of Orally Disintegrating Films Based On Starch and Hydroxypropyl Methylcellulose Incorporated With Cordia Verbenacea (erva Baleeira) Extract. Int J Biol Macromol. 2020 May 13;159:714-724. PubMed PMID: 32416298.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antioxidant and anti-inflammatory properties of orally disintegrating films based on starch and hydroxypropyl methylcellulose incorporated with Cordia verbenacea (erva baleeira) extract. AU - Bodini,Renata Barbosa, AU - Pugine,Silvana Marina Piccoli, AU - de Melo,Mariza Pires, AU - de Carvalho,Rosemary Aparecida, Y1 - 2020/05/13/ PY - 2020/02/21/received PY - 2020/04/27/revised PY - 2020/05/11/accepted PY - 2020/5/18/pubmed PY - 2020/5/18/medline PY - 2020/5/17/entrez KW - Cycloxygenase enzyme KW - Flavonoids KW - Hydroxypropyl methylcellulose KW - Oral mucosa KW - Oxygen radical KW - Starch SP - 714 EP - 724 JF - International journal of biological macromolecules JO - Int. J. Biol. Macromol. VL - 159 N2 - Cordia verbenacea (erva baleeira) is a plant used in indigenous folk medicine. Due to its pharmacological properties (antioxidant and anti-inflammatory), it can be used in the development of herbal medicines by different forms of administration such as orally disintegrating films (ODFs), which would facilitate the systemic release of its active ingredients. Considering the properties of the C. verbenacea and the advantages of ODFs, the objective of this work was the potential development of ODFs with antioxidant and anti-inflammatory properties. The polymeric matrices were produced based on starch and hydroxypropyl methylcellulose and additives with different C. verbenacea extract concentrations in order to obtain concentrations of 0.25, 0.50 and 0.75 mg flavonoids/ODF. The films were characterized by microscopy, infrared spectroscopy, mechanical properties, mucoadhesiveness, in vitro disintegration, in vitro release of flavonoids, antioxidant, and anti-inflammatory activities of the films. The ODFs showed good antioxidant activity and high anti-inflammatory capacity with inhibition of COX-2 enzyme. The stability study demonstrated the conservation of flavonoids and also the maintenance of the anti-inflammatory capacity of ODFs. This study demonstrated that orally disintegrating films have high potential for the delivery of natural bioactive compounds and the maintenance of their pharmacological properties. SN - 1879-0003 UR - https://www.unboundmedicine.com/medline/citation/32416298/Antioxidant_and_anti-inflammatory_properties_of_orally_disintegrating_films_based_on_starch_and_hydroxypropyl_methylcellulose_incorporated_with_Cordia_verbenacea_(erva_baleeira)_extract L2 - https://linkinghub.elsevier.com/retrieve/pii/S0141-8130(20)33223-2 DB - PRIME DP - Unbound Medicine ER -
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