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Association between maternal exposure to PM10 and polydactyly and syndactyly: A population-based case-control study in Liaoning province, China.
Environ Res. 2020 Aug; 187:109643.ER

Abstract

BACKGROUND

The number of studies on air pollution with birth defects as the primary outcome has increased dramatically over the past two decades, but the potential role of specific air pollutants in congenital limb anomalies remains unclear.

OBJECTIVES

To evaluate associations between preconception and first-trimester PM10 exposure and polydactyly and syndactyly in a population-based case-control study.

METHODS

Polydactyly cases (n = 2605), syndactyly cases (n = 595), and controls without any birth defects (n = 7950) born between 2010 and 2015 were selected from the Maternal and Child Health Certificate Registry of Liaoning Province. The monthly mean PM10 concentrations were obtained from 75 air monitoring stations, and the exposure assessment was based on the mean concentration of all stations in mother's residential city. A multivariable logistic regression model was constructed to calculate adjusted odds ratios (aORs) and 95% confidence intervals (CIs).

RESULTS

PM10 exposure was positively associated with the risks of polydactyly (preconception: aORT3 vs. T1 = 1.95, 95% CI 1.56-2.45, aOR = 1.06, 95% CI 1.01-1.10 [per 10-μg/m3 increment]; first-trimester: aORT3 vs. T1 = 2.51, 95% CI 2.00-3.15) and syndactyly (preconception: aORT3 vs. T1 = 2.86, 95% CI 1.98-4.13, aOR = 1.11, 95% CI 1.03-1.20 [per 10-μg/m3 increment]; first-trimester: aORT3 vs. T1 = 3.10, 95% CI 2.11-4.56). Analyses based on single month exposure windows basically showed similar positive associations. Additionally, these findings were robust in sensitivity analyses and broadly consistent across subgroups.

CONCLUSION

Our study suggest that preconception and first-trimester PM10 exposures are related to increased risks of polydactyly and syndactyly.

Authors+Show Affiliations

Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China. Electronic address: zhang_jy97@163.com.Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China. Electronic address: gongtt@sj-hospital.org.Department of Ophthalmology, Shenyang Women's and Children's Hospital, Shenyang, China. Electronic address: yanhonghuang_sy@sina.com.Department of Science and Education, Shenyang Maternity and Child Health Hospital, Shenyang, China. Electronic address: 630424294@qq.com.Department of Atmospheric Environment Monitoring, Liaoning Eco-environmental Monitoring Center, China. Electronic address: 1940223553@qq.com.Liaoning Women and Children's Health Hospital, Shenyang, China. Electronic address: 2378329665@qq.com.Department of Children's Health Prevention, Shenyang Maternity and Child Health Hospital, Shenyang, China. Electronic address: 2774809203@qq.com.School of Environmental and Chemical Engineering, Shenyang Ligong University, Shenyang, China. Electronic address: 2141438897@qq.com.Department of Atmospheric Environment Monitoring, Liaoning Eco-environmental Monitoring Center, China. Electronic address: 1014447357@qq.com.Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China. Electronic address: wuqj@sj-hospital.org.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32416360

Citation

Zhang, Jia-Yu, et al. "Association Between Maternal Exposure to PM10 and Polydactyly and Syndactyly: a Population-based Case-control Study in Liaoning Province, China." Environmental Research, vol. 187, 2020, p. 109643.
Zhang JY, Gong TT, Huang YH, et al. Association between maternal exposure to PM10 and polydactyly and syndactyly: A population-based case-control study in Liaoning province, China. Environ Res. 2020;187:109643.
Zhang, J. Y., Gong, T. T., Huang, Y. H., Li, J., Liu, S., Chen, Y. L., Li, L. L., Jiang, C. Z., Chen, Z. J., & Wu, Q. J. (2020). Association between maternal exposure to PM10 and polydactyly and syndactyly: A population-based case-control study in Liaoning province, China. Environmental Research, 187, 109643. https://doi.org/10.1016/j.envres.2020.109643
Zhang JY, et al. Association Between Maternal Exposure to PM10 and Polydactyly and Syndactyly: a Population-based Case-control Study in Liaoning Province, China. Environ Res. 2020;187:109643. PubMed PMID: 32416360.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between maternal exposure to PM10 and polydactyly and syndactyly: A population-based case-control study in Liaoning province, China. AU - Zhang,Jia-Yu, AU - Gong,Ting-Ting, AU - Huang,Yan-Hong, AU - Li,Jing, AU - Liu,Shu, AU - Chen,Yan-Ling, AU - Li,Li-Li, AU - Jiang,Cheng-Zhi, AU - Chen,Zong-Jiao, AU - Wu,Qi-Jun, Y1 - 2020/05/11/ PY - 2020/03/16/received PY - 2020/05/04/revised PY - 2020/05/04/accepted PY - 2020/5/18/pubmed PY - 2020/5/18/medline PY - 2020/5/17/entrez KW - Air pollution KW - PM(10) KW - Polydactyly KW - Syndactyly SP - 109643 EP - 109643 JF - Environmental research JO - Environ. Res. VL - 187 N2 - BACKGROUND: The number of studies on air pollution with birth defects as the primary outcome has increased dramatically over the past two decades, but the potential role of specific air pollutants in congenital limb anomalies remains unclear. OBJECTIVES: To evaluate associations between preconception and first-trimester PM10 exposure and polydactyly and syndactyly in a population-based case-control study. METHODS: Polydactyly cases (n = 2605), syndactyly cases (n = 595), and controls without any birth defects (n = 7950) born between 2010 and 2015 were selected from the Maternal and Child Health Certificate Registry of Liaoning Province. The monthly mean PM10 concentrations were obtained from 75 air monitoring stations, and the exposure assessment was based on the mean concentration of all stations in mother's residential city. A multivariable logistic regression model was constructed to calculate adjusted odds ratios (aORs) and 95% confidence intervals (CIs). RESULTS: PM10 exposure was positively associated with the risks of polydactyly (preconception: aORT3 vs. T1 = 1.95, 95% CI 1.56-2.45, aOR = 1.06, 95% CI 1.01-1.10 [per 10-μg/m3 increment]; first-trimester: aORT3 vs. T1 = 2.51, 95% CI 2.00-3.15) and syndactyly (preconception: aORT3 vs. T1 = 2.86, 95% CI 1.98-4.13, aOR = 1.11, 95% CI 1.03-1.20 [per 10-μg/m3 increment]; first-trimester: aORT3 vs. T1 = 3.10, 95% CI 2.11-4.56). Analyses based on single month exposure windows basically showed similar positive associations. Additionally, these findings were robust in sensitivity analyses and broadly consistent across subgroups. CONCLUSION: Our study suggest that preconception and first-trimester PM10 exposures are related to increased risks of polydactyly and syndactyly. SN - 1096-0953 UR - https://www.unboundmedicine.com/medline/citation/32416360/Association_between_maternal_exposure_to_PM10_and_polydactyly_and_syndactyly:_A_population-based_case-control_study_in_Liaoning_province,_China L2 - https://linkinghub.elsevier.com/retrieve/pii/S0013-9351(20)30536-3 DB - PRIME DP - Unbound Medicine ER -
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