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Acute inspiratory muscle exercise effect on glucose levels, glucose variability and autonomic control in patients with type 2 diabetes: A crossover randomized trial.
Auton Neurosci. 2020 07; 226:102669.AN

Abstract

Inspiratory muscle exercise (IME) can be an alternative to conventional exercise. We aimed to evaluate the effect of IME on glucose, glucose variability, and autonomic cardiovascular control in type 2 diabetes. Fourteen diabetic subjects were randomly assigned to IME with 2% maximal inspiratory pressure (PImax) or 60% PImax wearing a continuous glucose monitoring system for three days. Glucose variability [glucose variance (VAR), glucose coefficient of variation (CV%), glucose standard deviation (SD), and mean amplitude of glycemic excursions (MAGE)] were evaluated. Glucose reduction was observed in 5 min (60% of PImax 33.2% and 2% of PImax 32.0%), 60 min (60% of PImax 29.6% and 2% of PImax 31.4%) and 120 min (60% of PImax 21.4% and 2% of PImax 24.0%) after IME (vs.1 h before the exercise), with no difference between loads. This reduction in glucose levels was observed in all moments of the IME protocol. Glucose variability was reduced after 12 h and 18 h of the IME (ΔCV: P < 0.001, ΔSD: P < 0.001 and ΔVAR: P < 0.001) for both loads. No difference was found in MAGE (P = 0.594) after IME. Mean arterial pressure and heart rate rose during the exercise session with 60% of PImax. Although sufficiently strong to induce cardiovascular changes, an inspiratory muscle exercise session with 60% of PImax in subjects with type 2 diabetes has failed to induce any significant improvement in glucose, glucose variability and autonomic control, compared to the 2% Plmax exercise session.

Authors+Show Affiliations

Postgraduate Program in Cardiology, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; Exercise Pathophysiology Research Laboratory, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil. Electronic address: andressasilveiradeoliveira@yahoo.com.br.Faculty of Health Sciences, The University of Sydney, Lidcombe, NSW, Australia.Postgraduate Program in Endocrinology, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; Exercise Pathophysiology Research Laboratory, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.Sainte-Justine University Hospital Research Center, University of Montreal Depatment of pediatrics, Montreal, Quebec, Canada.Postgraduate Program in Cardiology, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.Postgraduate Program in Endocrinology, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.Institute of Science and Technology, Universidade Federal de São Paulo, São Paulo, Brazil.Postgraduate Program in Cardiology, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; Postgraduate Program in Endocrinology, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; Exercise Pathophysiology Research Laboratory, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil; Department of Internal Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

32416442

Citation

Schein, Andressa S O., et al. "Acute Inspiratory Muscle Exercise Effect On Glucose Levels, Glucose Variability and Autonomic Control in Patients With Type 2 Diabetes: a Crossover Randomized Trial." Autonomic Neuroscience : Basic & Clinical, vol. 226, 2020, p. 102669.
Schein ASO, Corrêa APS, Macedo ACP, et al. Acute inspiratory muscle exercise effect on glucose levels, glucose variability and autonomic control in patients with type 2 diabetes: A crossover randomized trial. Auton Neurosci. 2020;226:102669.
Schein, A. S. O., Corrêa, A. P. S., Macedo, A. C. P., Dartora, D. R., da Silveira, A. D., Severo, M. D., Casali, K. R., & Schaan, B. D. (2020). Acute inspiratory muscle exercise effect on glucose levels, glucose variability and autonomic control in patients with type 2 diabetes: A crossover randomized trial. Autonomic Neuroscience : Basic & Clinical, 226, 102669. https://doi.org/10.1016/j.autneu.2020.102669
Schein ASO, et al. Acute Inspiratory Muscle Exercise Effect On Glucose Levels, Glucose Variability and Autonomic Control in Patients With Type 2 Diabetes: a Crossover Randomized Trial. Auton Neurosci. 2020;226:102669. PubMed PMID: 32416442.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acute inspiratory muscle exercise effect on glucose levels, glucose variability and autonomic control in patients with type 2 diabetes: A crossover randomized trial. AU - Schein,Andressa S O, AU - Corrêa,Ana P S, AU - Macedo,Aline C P, AU - Dartora,Daniela R, AU - da Silveira,Anderson Donelli, AU - Severo,Mateus Dornelles, AU - Casali,Karina R, AU - Schaan,Beatriz D, Y1 - 2020/03/26/ PY - 2019/03/28/received PY - 2020/03/02/revised PY - 2020/03/22/accepted PY - 2020/5/18/pubmed PY - 2020/5/18/medline PY - 2020/5/17/entrez KW - Breathing exercises KW - Diabetes KW - Hyperglycemia SP - 102669 EP - 102669 JF - Autonomic neuroscience : basic & clinical JO - Auton Neurosci VL - 226 N2 - Inspiratory muscle exercise (IME) can be an alternative to conventional exercise. We aimed to evaluate the effect of IME on glucose, glucose variability, and autonomic cardiovascular control in type 2 diabetes. Fourteen diabetic subjects were randomly assigned to IME with 2% maximal inspiratory pressure (PImax) or 60% PImax wearing a continuous glucose monitoring system for three days. Glucose variability [glucose variance (VAR), glucose coefficient of variation (CV%), glucose standard deviation (SD), and mean amplitude of glycemic excursions (MAGE)] were evaluated. Glucose reduction was observed in 5 min (60% of PImax 33.2% and 2% of PImax 32.0%), 60 min (60% of PImax 29.6% and 2% of PImax 31.4%) and 120 min (60% of PImax 21.4% and 2% of PImax 24.0%) after IME (vs.1 h before the exercise), with no difference between loads. This reduction in glucose levels was observed in all moments of the IME protocol. Glucose variability was reduced after 12 h and 18 h of the IME (ΔCV: P < 0.001, ΔSD: P < 0.001 and ΔVAR: P < 0.001) for both loads. No difference was found in MAGE (P = 0.594) after IME. Mean arterial pressure and heart rate rose during the exercise session with 60% of PImax. Although sufficiently strong to induce cardiovascular changes, an inspiratory muscle exercise session with 60% of PImax in subjects with type 2 diabetes has failed to induce any significant improvement in glucose, glucose variability and autonomic control, compared to the 2% Plmax exercise session. SN - 1872-7484 UR - https://www.unboundmedicine.com/medline/citation/32416442/Acute_inspiratory_muscle_exercise_effect_on_glucose_levels,_glucose_variability_and_autonomic_control_in_patients_with_type_2_diabetes:_A_crossover_randomized_trial L2 - https://linkinghub.elsevier.com/retrieve/pii/S1566-0702(19)30089-X DB - PRIME DP - Unbound Medicine ER -
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