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COVID-19: Pathogenesis, cytokine storm and therapeutic potential of interferons.
Cytokine Growth Factor Rev. 2020 06; 53:66-70.CG

Abstract

The outbreak of the novel SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) responsible for coronavirus disease 2019 (COVID-19) has developed into an unprecedented global pandemic. Clinical investigations in patients with COVID-19 has shown a strong upregulation of cytokine and interferon production in SARS-CoV2- induced pneumonia, with an associated cytokine storm syndrome. Thus, the identification of existing approved therapies with proven safety profiles to treat hyperinflammation is a critical unmet need in order to reduce COVI-19 associated mortality. To date, no specific therapeutic drugs or vaccines are available to treat COVID-19 patients. This review evaluates several options that have been proposed to control SARS-CoV2 hyperinflammation and cytokine storm, eincluding antiviral drugs, vaccines, small-molecules, monoclonal antibodies, oligonucleotides, peptides, and interferons (IFNs).

Authors+Show Affiliations

Department of Pharmacy, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 310053, China.Department of Pharmacy, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 310053, China.Department of Pharmacy, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 310053, China.Guangdong Provincial Key Laboratory of New Drug Screening, Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.Non-Coding RNA and Drug Discovery Key Laboratory of Sichuan Province, Chengdu Medical College, Chengdu, 610500, China. Electronic address: jiaxu@cmc.edu.cn.Department of Pharmacy, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 310053, China. Electronic address: guoyinkai1@126.com.

Pub Type(s)

Letter
Review

Language

eng

PubMed ID

32418715

Citation

Nile, Shivraj Hariram, et al. "COVID-19: Pathogenesis, Cytokine Storm and Therapeutic Potential of Interferons." Cytokine & Growth Factor Reviews, vol. 53, 2020, pp. 66-70.
Nile SH, Nile A, Qiu J, et al. COVID-19: Pathogenesis, cytokine storm and therapeutic potential of interferons. Cytokine Growth Factor Rev. 2020;53:66-70.
Nile, S. H., Nile, A., Qiu, J., Li, L., Jia, X., & Kai, G. (2020). COVID-19: Pathogenesis, cytokine storm and therapeutic potential of interferons. Cytokine & Growth Factor Reviews, 53, 66-70. https://doi.org/10.1016/j.cytogfr.2020.05.002
Nile SH, et al. COVID-19: Pathogenesis, Cytokine Storm and Therapeutic Potential of Interferons. Cytokine Growth Factor Rev. 2020;53:66-70. PubMed PMID: 32418715.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - COVID-19: Pathogenesis, cytokine storm and therapeutic potential of interferons. AU - Nile,Shivraj Hariram, AU - Nile,Arti, AU - Qiu,Jiayin, AU - Li,Lin, AU - Jia,Xu, AU - Kai,Guoyin, Y1 - 2020/05/07/ PY - 2020/04/11/received PY - 2020/05/01/revised PY - 2020/05/01/accepted PY - 2020/5/19/pubmed PY - 2020/7/1/medline PY - 2020/5/19/entrez KW - COVID-19 KW - Coronavirus KW - Interferons KW - Recombinant KW - SARS-CoV-2 SP - 66 EP - 70 JF - Cytokine & growth factor reviews JO - Cytokine Growth Factor Rev VL - 53 N2 - The outbreak of the novel SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) responsible for coronavirus disease 2019 (COVID-19) has developed into an unprecedented global pandemic. Clinical investigations in patients with COVID-19 has shown a strong upregulation of cytokine and interferon production in SARS-CoV2- induced pneumonia, with an associated cytokine storm syndrome. Thus, the identification of existing approved therapies with proven safety profiles to treat hyperinflammation is a critical unmet need in order to reduce COVI-19 associated mortality. To date, no specific therapeutic drugs or vaccines are available to treat COVID-19 patients. This review evaluates several options that have been proposed to control SARS-CoV2 hyperinflammation and cytokine storm, eincluding antiviral drugs, vaccines, small-molecules, monoclonal antibodies, oligonucleotides, peptides, and interferons (IFNs). SN - 1879-0305 UR - https://www.unboundmedicine.com/medline/citation/32418715/COVID_19:_Pathogenesis_cytokine_storm_and_therapeutic_potential_of_interferons_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1359-6101(20)30070-8 DB - PRIME DP - Unbound Medicine ER -