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The liver injury and gastrointestinal symptoms in patients with Coronavirus Disease 19: A systematic review and meta-analysis.
Clin Res Hepatol Gastroenterol. 2020 10; 44(5):653-661.CR

Abstract

Backgrounds

Since December 2019, novel coronavirus (SARS-CoV-2)-infected pneumonia (COVID-19) occurred in Wuhan, and rapidly spread throughout China. Our study aimed to evaluate the association of liver injury and gastrointestinal symptoms (GIS) with the progression of COVID-19.

Methods

A comprehensive search was performed on the PubMed to identify eligible studies that summarized the liver injury and GIS in COVID-19.

Results

A total of 21 studies with 3024 patients were included. Up to 53% patients had liver dysfunctions and the degree of liver damage was associated the severity of the disease. The prevalence of diarrhoea, nausea/vomiting or abdominal pain in patients with COVID-19 were 9.1%, 5.2% and 3.5%, respectively. No significant was found in the prevalence of diarrhoea (OR, 1.24; 95%CI, 0.90 to 1.72; I 2 = 0%, P = 0.19) and nausea/vomiting (OR, 1.24; 95%CI, 0.57 to 2.69; I 2 = 61%, P = 0.58) between severe and non-severe patients. In addition, diarrhoea (OR, 1.22; 95%CI, 0.50 to 2.98; I 2 = 0%, P = 0.66) and nausea/vomiting (OR, 1.09; 95%CI, 0.46 to 2.62; I 2 = 0%, P = 0.84) were not associated with the prognosis of COVID-19 patients.

Conclusions

The incidences of GIS in patients with COVID-19 is relatively low and are not associated with the COVID-19 progression. Gastroenterologists should pay more attention to the liver injury induced by SARS-CoV-2 during the course of infection.

Authors+Show Affiliations

Department of Gastroenterology, Zhongnan Hospital of Wuhan University, 430071 Wuhan, China; Hubei Clinical Center & Key Lab of Intestinal & Colorectal Diseases, Wuhan, China.Department of Gastroenterology, Zhongnan Hospital of Wuhan University, 430071 Wuhan, China; Hubei Clinical Center & Key Lab of Intestinal & Colorectal Diseases, Wuhan, China.Department of Gastroenterology, Zhongnan Hospital of Wuhan University, 430071 Wuhan, China; Hubei Clinical Center & Key Lab of Intestinal & Colorectal Diseases, Wuhan, China. Electronic address: liujing810430@hotmail.com.Department of Gastroenterology, Zhongnan Hospital of Wuhan University, 430071 Wuhan, China; Hubei Clinical Center & Key Lab of Intestinal & Colorectal Diseases, Wuhan, China. Electronic address: fanndywang@foxmail.com.Department of Gastroenterology, Zhongnan Hospital of Wuhan University, 430071 Wuhan, China; Hubei Clinical Center & Key Lab of Intestinal & Colorectal Diseases, Wuhan, China. Electronic address: zhaoqiuwhu@163.com.

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Systematic Review

Language

eng

PubMed ID

32418852

Citation

Wang, Haizhou, et al. "The Liver Injury and Gastrointestinal Symptoms in Patients With Coronavirus Disease 19: a Systematic Review and Meta-analysis." Clinics and Research in Hepatology and Gastroenterology, vol. 44, no. 5, 2020, pp. 653-661.
Wang H, Qiu P, Liu J, et al. The liver injury and gastrointestinal symptoms in patients with Coronavirus Disease 19: A systematic review and meta-analysis. Clin Res Hepatol Gastroenterol. 2020;44(5):653-661.
Wang, H., Qiu, P., Liu, J., Wang, F., & Zhao, Q. (2020). The liver injury and gastrointestinal symptoms in patients with Coronavirus Disease 19: A systematic review and meta-analysis. Clinics and Research in Hepatology and Gastroenterology, 44(5), 653-661. https://doi.org/10.1016/j.clinre.2020.04.012
Wang H, et al. The Liver Injury and Gastrointestinal Symptoms in Patients With Coronavirus Disease 19: a Systematic Review and Meta-analysis. Clin Res Hepatol Gastroenterol. 2020;44(5):653-661. PubMed PMID: 32418852.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The liver injury and gastrointestinal symptoms in patients with Coronavirus Disease 19: A systematic review and meta-analysis. AU - Wang,Haizhou, AU - Qiu,Peishan, AU - Liu,Jing, AU - Wang,Fan, AU - Zhao,Qiu, Y1 - 2020/05/12/ PY - 2020/5/19/pubmed PY - 2020/10/29/medline PY - 2020/5/19/entrez KW - COVID-19 KW - Diarrhoea KW - Gastrointestinal symptoms KW - Liver injury KW - SARS-CoV-2 SP - 653 EP - 661 JF - Clinics and research in hepatology and gastroenterology JO - Clin Res Hepatol Gastroenterol VL - 44 IS - 5 N2 - Backgrounds: Since December 2019, novel coronavirus (SARS-CoV-2)-infected pneumonia (COVID-19) occurred in Wuhan, and rapidly spread throughout China. Our study aimed to evaluate the association of liver injury and gastrointestinal symptoms (GIS) with the progression of COVID-19. Methods: A comprehensive search was performed on the PubMed to identify eligible studies that summarized the liver injury and GIS in COVID-19. Results: A total of 21 studies with 3024 patients were included. Up to 53% patients had liver dysfunctions and the degree of liver damage was associated the severity of the disease. The prevalence of diarrhoea, nausea/vomiting or abdominal pain in patients with COVID-19 were 9.1%, 5.2% and 3.5%, respectively. No significant was found in the prevalence of diarrhoea (OR, 1.24; 95%CI, 0.90 to 1.72; I 2 = 0%, P = 0.19) and nausea/vomiting (OR, 1.24; 95%CI, 0.57 to 2.69; I 2 = 61%, P = 0.58) between severe and non-severe patients. In addition, diarrhoea (OR, 1.22; 95%CI, 0.50 to 2.98; I 2 = 0%, P = 0.66) and nausea/vomiting (OR, 1.09; 95%CI, 0.46 to 2.62; I 2 = 0%, P = 0.84) were not associated with the prognosis of COVID-19 patients. Conclusions: The incidences of GIS in patients with COVID-19 is relatively low and are not associated with the COVID-19 progression. Gastroenterologists should pay more attention to the liver injury induced by SARS-CoV-2 during the course of infection. SN - 2210-741X UR - https://www.unboundmedicine.com/medline/citation/32418852/The_liver_injury_and_gastrointestinal_symptoms_in_patients_with_Coronavirus_Disease_19:_A_systematic_review_and_meta_analysis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S2210-7401(20)30117-0 DB - PRIME DP - Unbound Medicine ER -