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Immunoglobulins in the treatment of COVID-19 infection: Proceed with caution!
Clin Immunol. 2020 Jul; 216:108459.CI

Abstract

The COVID-19 pandemic is one of the greatest infectious challenges in recent history. Presently, few treatment options exist and the availability of effective vaccines is at least one year away. There is an urgent need to find currently available, effective therapies in the treatment of patients with COVID-19 infection. In this review, we compare and contrast the use of intravenous immunoglobulin and hyperimmune globulin in the treatment of COVID-19 infection.

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Authors+Show Affiliations

Nguyen AA
Division of Immunology, Boston Children's Hospital, Boston, MA, United States of America.
Habiballah SB
Division of Immunology, Boston Children's Hospital, Boston, MA, United States of America.
Platt CD
Division of Immunology, Boston Children's Hospital, Boston, MA, United States of America.
Geha RS
Division of Immunology, Boston Children's Hospital, Boston, MA, United States of America.
Chou JS
Division of Immunology, Boston Children's Hospital, Boston, MA, United States of America.
McDonald DR
Division of Immunology, Boston Children's Hospital, Boston, MA, United States of America. Electronic address: Douglas.McDonald@childrens.harvard.edu.

MeSH

Adaptive ImmunityAngiotensin-Converting Enzyme 2Antibody-Dependent EnhancementBetacoronavirusCOVID-19Coronavirus InfectionsCytokine Release SyndromeGene ExpressionHumansImmunity, InnateImmunization, PassiveImmunoglobulins, IntravenousImmunologic FactorsMolecular Targeted TherapyPandemicsPeptidyl-Dipeptidase APneumonia, ViralSARS-CoV-2Spike Glycoprotein, CoronavirusT-LymphocytesCOVID-19 Serotherapy

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

32418917

Citation

Nguyen, Alan A., et al. "Immunoglobulins in the Treatment of COVID-19 Infection: Proceed With Caution!" Clinical Immunology (Orlando, Fla.), vol. 216, 2020, p. 108459.
Nguyen AA, Habiballah SB, Platt CD, et al. Immunoglobulins in the treatment of COVID-19 infection: Proceed with caution! Clin Immunol. 2020;216:108459.
Nguyen, A. A., Habiballah, S. B., Platt, C. D., Geha, R. S., Chou, J. S., & McDonald, D. R. (2020). Immunoglobulins in the treatment of COVID-19 infection: Proceed with caution! Clinical Immunology (Orlando, Fla.), 216, 108459. https://doi.org/10.1016/j.clim.2020.108459
Nguyen AA, et al. Immunoglobulins in the Treatment of COVID-19 Infection: Proceed With Caution. Clin Immunol. 2020;216:108459. PubMed PMID: 32418917.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunoglobulins in the treatment of COVID-19 infection: Proceed with caution! AU - Nguyen,Alan A, AU - Habiballah,Saddiq B, AU - Platt,Craig D, AU - Geha,Raif S, AU - Chou,Janet S, AU - McDonald,Douglas R, Y1 - 2020/05/11/ PY - 2020/5/5/received PY - 2020/5/5/accepted PY - 2020/5/19/pubmed PY - 2020/7/14/medline PY - 2020/5/19/entrez KW - COVID-19 KW - Coronavirus KW - Hyperimmune globulin KW - Intravenous immunoglobulin KW - SARS-CoV-2 SP - 108459 EP - 108459 JF - Clinical immunology (Orlando, Fla.) JO - Clin Immunol VL - 216 N2 - The COVID-19 pandemic is one of the greatest infectious challenges in recent history. Presently, few treatment options exist and the availability of effective vaccines is at least one year away. There is an urgent need to find currently available, effective therapies in the treatment of patients with COVID-19 infection. In this review, we compare and contrast the use of intravenous immunoglobulin and hyperimmune globulin in the treatment of COVID-19 infection. SN - 1521-7035 UR - https://www.unboundmedicine.com/medline/citation/32418917/Immunoglobulins_in_the_treatment_of_COVID_19_infection:_Proceed_with_caution DB - PRIME DP - Unbound Medicine ER -