Tags

Type your tag names separated by a space and hit enter

Influence of hair treatments on detection of antiretrovirals by mass spectrometry imaging.
Analyst. 2020 Jul 07; 145(13):4540-4550.A

Abstract

Analysis of drugs in hair by mass spectrometry imaging (MSI) has great potential as an objective, long-term measure of medication adherence. However, the fidelity of the chemical record in hair may be compromised by any cosmetic hair treatments. Here, we investigate infrared matrix-assisted laser desorption electrospray ionization (IR-MALDESI) MSI response to multiple antiretrovirals (ARVs) in cosmetically treated hair. Hair strands from patients on different ARV regimens were mechanically treated with dye, bleach, and relaxer. The treatments had little or no effect relative to untreated controls for cobicistat, abacavir, dolutegravir, maraviroc, efavirenz, and darunavir, but all three treatments removed emtricitabine (FTC) to undetectable levels from patient hair strands. We also evaluated hair strands by IR-MALDESI MSI from 8 patients on FTC-based regimens who reported a range of hair treatments at varying recency prior to hair collection. While FTC was undetectable in the treated portion of these hair strands, ARVs coadministered with FTC remained detectable in hair strands after treatment. We conclude that IR-MALDESI MSI can be used when measuring adherence to ARV therapy, provided that ARVs other than FTC are targeted in people using hair treatments.

Authors+Show Affiliations

Department of Chemistry, Furman University, Greenville, South Carolina 29613, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32420552

Citation

Gilliland, William M., et al. "Influence of Hair Treatments On Detection of Antiretrovirals By Mass Spectrometry Imaging." The Analyst, vol. 145, no. 13, 2020, pp. 4540-4550.
Gilliland WM, White NR, Yam BH, et al. Influence of hair treatments on detection of antiretrovirals by mass spectrometry imaging. Analyst. 2020;145(13):4540-4550.
Gilliland, W. M., White, N. R., Yam, B. H., Mwangi, J. N., Prince, H. M. A., Weideman, A. M., Kashuba, A. D. M., & Rosen, E. P. (2020). Influence of hair treatments on detection of antiretrovirals by mass spectrometry imaging. The Analyst, 145(13), 4540-4550. https://doi.org/10.1039/d0an00478b
Gilliland WM, et al. Influence of Hair Treatments On Detection of Antiretrovirals By Mass Spectrometry Imaging. Analyst. 2020 Jul 7;145(13):4540-4550. PubMed PMID: 32420552.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of hair treatments on detection of antiretrovirals by mass spectrometry imaging. AU - Gilliland,William M, AU - White,Nicole R, AU - Yam,Bryan H, AU - Mwangi,Joseph N, AU - Prince,Heather M A, AU - Weideman,Ann Marie, AU - Kashuba,Angela D M, AU - Rosen,Elias P, Y1 - 2020/05/18/ PY - 2020/5/19/pubmed PY - 2020/5/19/medline PY - 2020/5/19/entrez SP - 4540 EP - 4550 JF - The Analyst JO - Analyst VL - 145 IS - 13 N2 - Analysis of drugs in hair by mass spectrometry imaging (MSI) has great potential as an objective, long-term measure of medication adherence. However, the fidelity of the chemical record in hair may be compromised by any cosmetic hair treatments. Here, we investigate infrared matrix-assisted laser desorption electrospray ionization (IR-MALDESI) MSI response to multiple antiretrovirals (ARVs) in cosmetically treated hair. Hair strands from patients on different ARV regimens were mechanically treated with dye, bleach, and relaxer. The treatments had little or no effect relative to untreated controls for cobicistat, abacavir, dolutegravir, maraviroc, efavirenz, and darunavir, but all three treatments removed emtricitabine (FTC) to undetectable levels from patient hair strands. We also evaluated hair strands by IR-MALDESI MSI from 8 patients on FTC-based regimens who reported a range of hair treatments at varying recency prior to hair collection. While FTC was undetectable in the treated portion of these hair strands, ARVs coadministered with FTC remained detectable in hair strands after treatment. We conclude that IR-MALDESI MSI can be used when measuring adherence to ARV therapy, provided that ARVs other than FTC are targeted in people using hair treatments. SN - 1364-5528 UR - https://www.unboundmedicine.com/medline/citation/32420552/Influence_of_hair_treatments_on_detection_of_antiretrovirals_by_mass_spectrometry_imaging L2 - https://doi.org/10.1039/d0an00478b DB - PRIME DP - Unbound Medicine ER -
Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.